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Use of probiotics in preparing composition for treating and preventing hand-foot-mouth disease

A technology for hand, foot and mouth disease and probiotics, applied in the field of biological medicine, can solve problems such as side effects, impact on children's health, unsatisfactory treatment effect, etc., and achieve the effect of inhibiting replication

Active Publication Date: 2012-08-29
QINGDAO EASTSEA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for the treatment of HFMD, and the clinical drugs mainly include antiviral drugs, traditional Chinese medicines and antibacterial drugs, etc., the therapeutic effect is not ideal, and there are side effects, which affect children's health, and treatment and prevention of infection have become medical problems. The drug of the present invention The new use solves this medical problem. It can not only effectively treat hand, foot and mouth disease, but also prevent infection when HFMD is prevalent, and has no side effects, and will not damage children's health. It has great social significance. We hereby apply for a patent for this invention.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0035] Medicine Preparation Example 1 Preparation of Oral Clostridium Butyricum Live Bacteria Powder

[0036] 1. Preparation of bacteria powder

[0037] Take a Clostridium butyricum strain tube, dissolve it in a sterilized 100mL Erlenmeyer flask filled with 10mL normal saline and appropriate amount of glass beads, activate it in a water bath at 75°C for 10 minutes, draw 1mL of the bacterial suspension with a 1mL sterile pipette, and inoculate Put in a 250mL Erlenmeyer flask with 50mL expansion medium, place it in a rocking bed at 37°C for 24 hours at a constant temperature and shake (190rpm), transfer to a 2500mL Erlenmeyer flask with 450mL of expansion medium, and culture for 24 hours at a constant temperature of 37°C , transfer to a seed tank with 4.5L of expansion medium after microscopic examination, and then transfer to a 45L fermentation medium for anaerobic culture (aeration volume 3:1) for 24 hours. In the fermenter, 37 ℃ of anaerobic cultivation (aeration rate 3: 1) ...

preparation Embodiment 2

[0040] Drug Preparation Example 2 Preparation of Oral Bacillus Coagulans Live Bacteria Powder

[0041] 1. Preparation of bacteria powder:

[0042] Take a tube of Bacillus coagulans strain, dissolve it in a sterilized 100mL Erlenmeyer flask filled with 10mL normal saline and appropriate amount of glass beads, activate in a water bath at 75°C for 10 minutes, draw 1mL of the bacterial suspension with a 1mL sterile pipette, and inoculate Place in a 250mL Erlenmeyer flask with 50mL of expansion medium, place it in a rocking bed at 37°C for 24 hours at a constant temperature and shake (190rpm), transfer it to a 2500mL Erlenmeyer flask with 450mL of expansion medium, and cultivate for 24 hours at a constant temperature of 37°C for shaking , transfer to a seed tank with 4.5L of expansion medium after microscopic examination without miscellaneous bacteria, aerobic culture (aeration volume 3:1) for 24 hours, microscopic examination without miscellaneous bacteria, then transfer to 45L fe...

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PUM

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Abstract

The invention discloses an application of probiotic bacteria in preparing compositions for treating hand-foot-and-mouth disease and preventing infection of hand-foot-and-mouth disease virus, particularly to a new application of probiotic bacteria in preparing medicaments for treating hand-foot-and-mouth disease and preventing infection of hand-foot-and-mouth disease virus. The probiotic bacteria include Clostridium butyricum, Bacillus bifidus, Bacillus coagulans, Lactobacilli sp., Streptococcus sp., Bacillus subtilis, etc.; and the compositions include medicaments, health products and drinks.

Description

technical field [0001] The present invention relates to the new application of probiotics such as Clostridium butyricum, Bacillus coagulans and Bifidobacterium, in particular to the preparation of probiotics such as Clostridium butyricum, Bacillus coagulans and Bifidobacterium as active ingredients in the preparation of a combination for the treatment and prevention of hand, foot and mouth disease. The application in medicine belongs to the field of biopharmaceuticals. Background technique [0002] Probiotics are a kind of active microorganisms that play a role by improving the balance of the host's intestinal flora. They are important physiological bacteria in the human intestinal tract. They can promote the ecological balance of the intestinal flora and improve the intestinal flora structure, promoting the proliferation of beneficial bacteria in the intestinal tract, and inhibiting the growth of harmful bacteria and other important physiological functions. At present, prob...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/74A61P31/12A61K35/741A61K35/742A61K35/744A61K35/745A61K35/747
Inventor 崔云龙李洪福
Owner QINGDAO EASTSEA PHARMA
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