Application of small polypeptide molecules in the preparation of drugs for the prevention and treatment of ischemic cerebrovascular disease

A technology for cerebrovascular diseases and small molecules, which is applied in the field of application of small polypeptide molecules in the preparation of drugs for the prevention and treatment of ischemic cerebrovascular diseases, and can solve problems such as peptides that have not yet been seen

Active Publication Date: 2011-12-21
GUILIN EIGHT PLUS ONE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the use of this peptide in cerebrovascular diseases

Method used

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  • Application of small polypeptide molecules in the preparation of drugs for the prevention and treatment of ischemic cerebrovascular disease
  • Application of small polypeptide molecules in the preparation of drugs for the prevention and treatment of ischemic cerebrovascular disease
  • Application of small polypeptide molecules in the preparation of drugs for the prevention and treatment of ischemic cerebrovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: The preparation method of polypeptide small molecule

[0012] 1. The amino acid sequence of the pentapeptide is shown in SEQ ID NO: 1: Met-Gln-Cys-Asn-Ser

[0013] 2. The amino acid sequence of the tripeptide is shown in SEQ ID NO: 2: Cys-Asn-Ser

[0014] The above pentapeptide and tripeptide molecules were synthesized by Shanghai Sangong Biotechnology Co., Ltd., with a purity of more than 95%. Example 2: Animal experiment of small polypeptide molecules used in the treatment of ischemic cerebrovascular disease

Embodiment 2

[0014] The above pentapeptide and tripeptide molecules were synthesized by Shanghai Sangong Biotechnology Co., Ltd., with a purity of more than 95%. Example 2: Animal experiment of small polypeptide molecules used in the treatment of ischemic cerebrovascular disease

[0015] The pharmacological experiment of making focal cerebral ischemia model by mouse suture method is a commonly used animal experiment to verify that drugs have the effect of preventing and treating ischemic cerebrovascular disease (Yin XM, Luo Y, Cao G, Bai L, Pei W, Kuharsky DK, Chen J.Bid-mediated mitochondrial pathway is critical to ischemic neuronalapoptosis and focal cerebral ischemia.J Biol Chem.2002 Nov1;277(44):42074-81.), so it was used to verify the effect of the polypeptide molecule on cerebral ischemia in experimental animals protective effect.

[0016] 1. Animals

[0017] C57 / 6BL mice, male, weighing 20-24 g, were reared in groups of 10 mice / cage, divided into 8 groups in total. Bought from th...

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Abstract

The invention relates to the technical field of biomedicine, and relates to the application of small polypeptide molecules in the preparation of drugs for preventing and treating ischemic cerebrovascular diseases. The research of the present invention finds that the polypeptide active molecule and polypeptide splicing body extracted from the secretion fluid of amoeba histolytica have the pharmacological effect of preventing and treating ischemic cerebrovascular disease. The present invention has undergone a pharmacological test on a mouse model of focal cerebral ischemia, and the results show that the pentapeptide and tripeptide of the present invention can significantly reduce the area of ​​brain damage caused by cerebral ischemia-reperfusion in mice, and significantly improve ischemia in mice. subsequent neurobehavior. Compared with similar protein drugs, the peptide small molecule has a strong brain protective effect; and because of its small molecular weight, it is easy to penetrate the blood-brain barrier, and has a significant advantage in brain permeability. Therefore, the small polypeptide molecule provided by the invention has good application prospects in the preparation of drugs for preventing and treating ischemic cerebrovascular diseases.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of small polypeptide molecules in the preparation of drugs for the prevention and treatment of ischemic cerebrovascular diseases. Background technique [0002] Ischemic cerebrovascular disease (ischemic stroke) is one of the diseases with the highest morbidity, mortality and disability rate in the world, which greatly threatens the health and quality of life of human beings, especially the elderly, and has become a global Huge burden on society's health resources. Clinically, the mortality and disability rate of ischemic stroke has taken the first place among neurological diseases. At present, there are few effective drugs used in the treatment of ischemic cerebrovascular disease at home and abroad. Therefore, it is of great significance to carry out in-depth research on drug prevention and treatment of ischemic cerebrovascular disease. [0003] An anti-inf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/08A61K38/06A61P9/10
Inventor 杨鹏远芮耀诚章越凡
Owner GUILIN EIGHT PLUS ONE PHARMA CO LTD
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