Method for extracting and preparing total saponin of compound abnormal savda mature agent

A total saponin and abnormal technology, which is applied in the field of extraction and preparation of total saponin, can solve the problem of high total saponin content of abnormal black bile maturation agent, and achieve the effects of low cost, technological progress, and wide application range

Inactive Publication Date: 2009-02-25
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides for the first time a preparation method of the total saponin extract of the abnormal black gallbladder ripening agent, which is simple and convenient, low in cost, free from environmental pollution and safe, and the obtained abnormal black gallbladder ripening agent has a high content of total saponin, and is suitable for large-scale production Production, so far no reports at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 3kg of dry powder of abnormal black gallbladder ripening agent, add 15000mL of 90°C hot water, stir for 30 minutes to fully dissolve, let stand at room temperature for 24 hours, and filter. Add 22,500 mL of 95% ethanol to the filtrate, stir for 30 minutes, let stand at 22°C for 24 hours, filter, concentrate the filtrate to a relative density of 1.30; Elute with 20% ethanol, discard the water and 20% ethanol eluate, then elute with 60% ethanol, collect the eluate; recover ethanol from the eluate under reduced pressure, concentrate until no alcohol smell; add 95% ethanol to the concentrate Dissolve, filter, decolorize and purify the filtrate with activated carbon, filter to obtain the total saponin extract of abnormal black gallbladder mature agent, concentrate under reduced pressure, vacuum dry, and pulverize to obtain the total saponin product of abnormal black gallbladder mature agent, colorimetric method The purity of total saponins was measured to be 58.2%.

Embodiment 2

[0019] Take 3 kg of dry powder of abnormal black gallbladder ripening agent, add 16000 mL of 86°C hot water, stir for 35 minutes to fully dissolve, let stand at room temperature for 32 hours, and filter. Add 22000mL 90% ethanol to the filtrate, stir for 35 minutes, let stand at 20°C for 32 hours, filter, concentrate the filtrate to a relative density of 1.28; , 30% ethanol for elution, discard water and 30% ethanol eluate, then elute with 65% ethanol, collect eluate; eluate is decompressed to recover ethanol, concentrated to no alcohol smell; concentrate is added with 95% Dissolved in ethanol, filtered, and the filtrate was decolorized and purified by activated carbon, filtered to obtain the total saponin extract of the abnormal black gallbladder mature agent, concentrated under reduced pressure, spray-dried, and pulverized to obtain the total saponin product of the abnormal black gallbladder mature agent, colorimetric The purity of total saponins measured by the method was 67...

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Abstract

The invention provides a method for extracting and preparing total saponin of compound abnormal savda munziq; wherein, the abnormal savda munziq is prepared by ten traditional Chinese medicinal materials including microcos fruit, oxtongue, liquorice, capillaire and humifuse euphorbia by certain proportion; the medicinal materials are decocted, soaked, filtered, concentrated by decompressing and dried into solid extractum which is crushed into the dry powder of abnormal savda munziq. The dry powder is dissolved in hot water and filtered; the filtrate is added with ethanol and stirred and filtered; the filtrate is concentrated and the obtained concentrated solution is diluted by water and goes through macroporous resin and is eluted; the ethanol is recovered by decompression; the eluant is concentrated till no ethanol smell or is further dried into dry powder. The concentrated solution or the dry powder is added with water or ethanol solution and filtered. The obtained filtrate is decolored and purified by active carbon and filtered to finally obtain the total saponin extract of abnormal savda munziq; the total saponin extract is concentrated by decompressing, dried and crushed to obtain the total saponin product of the abnormal savda munziq with a pureness of over 55percent. The extraction and preparation method is characterized by low cost, simplicity, practicality and safety, and the prepared total saponin can be prepared into capsules, tablets, oral liquid, granules, medical potion, syrup and pills.

Description

technical field [0001] The invention relates to the extraction and preparation of total saponins, especially the improvement of purity and method, and is particularly suitable for the extraction and preparation of total saponins of a compound abnormal black bile maturation agent. Background technique [0002] Abnormal black gallbladder ripening agent is a Uyghur medicine compound prepared by preparing ten kinds of medicinal materials such as ragwort, Buglossus, licorice, maidenhair fern, and chrysanthemum in proportion, and then decocting, soaking, filtering, and diluting The preparation is mainly used to treat tumors, diabetes, hypertension, coronary heart disease and other intractable diseases caused by Uighur medicine syndrome - abnormal black bile syndrome. The principle of treatment for diseases caused by abnormal savage syndrome is to first use the abnormal savage maturation agent to accumulate the abnormal savage that causes the disease to the intestinal mucosa, and t...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61P39/06A61P3/10A61P9/10A61P9/12A61P35/00
Inventor 哈木拉提·吾甫尔阿不都热依木·玉苏甫木拉提·克扎衣别克
Owner XINJIANG MEDICAL UNIV
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