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Chinese medicinal composition as well as preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve problems such as sperm-egg fusion, decreased fertilization ability, decreased sperm motility, ICSI failure, etc.

Inactive Publication Date: 2009-03-04
SHANGHAI INST OF PLANNED PARENTHOOD RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many studies have shown that ROS production in semen, decreased sperm motility, sperm-egg fusion and decreased fertilization ability can also lead to ICSI failure

Method used

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  • Chinese medicinal composition as well as preparation method and application thereof
  • Chinese medicinal composition as well as preparation method and application thereof
  • Chinese medicinal composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0147] The preparation method of pharmaceutical composition

[0148] The pharmaceutical composition of the present invention can be prepared by conventional methods, and in one embodiment, comprises steps:

[0149] (1) mixing the essential components or their extracts to obtain a mixture, the essential components are (a) 15-90 parts by weight containing traditional Chinese medicines that provide sperm motility energy, and the traditional Chinese medicines that provide sperm motility energy include Lycium barbarum (b) 15-60 parts by weight of traditional Chinese medicine that strengthens adenosine triphosphate, and the traditional Chinese medicine that strengthens adenosine triphosphate includes Chinese yam; (c) 70-330 parts by weight of traditional Chinese medicine that has antioxidant effect, and the described The effective traditional Chinese medicine includes angelica, astragalus, white peony root, schisandra, dodder, rehmannia glutinosa, cornus, tortoise shell, turtle shel...

Embodiment 1—3

[0169] Preparation of pharmaceutical compositions

[0170]

[0171]

[0172] Mix the above-mentioned medicinal materials according to the formula, add water for the first time as the total weight of medicinal materials (g) × 10ml, and decoct with slow fire for 40-50 minutes; add water for the second time as the total weight of medicinal materials (g) × 6ml, and fry for 30-35 minutes . Every dose is decocted 2 times, obtains pharmaceutical composition (decoction) of the present invention altogether about 300ml after mixing.

Embodiment 4

[0174] Pharmacodynamic test of pharmaceutical composition

[0175] 1. Materials and methods

[0176] 1.1 Research object and grouping

[0177] From March 2005 to March 2007, 155 male infertile patients with severe oligozoospermia and asthenozoospermia (non-obstructive spontaneous ejaculation) who were treated at the Shanghai Family Planning Research Institute of Fudan University School of Medicine and the Reproductive Medicine Center of Shanghai Ruijin Hospital were selected. example. Patients were divided into two groups according to the treatment method used:

[0178] 1. In the ICSI group (n=77), 5 patients gave up the transplant cycle due to the prevention of ovarian hyperstimulation (OHSS), and 2 patients in the 72 transplant cycles experienced severe ovarian hyperstimulation;

[0179] 2. ICSI+TCM group (n=82). 4 cases of transplantation cycles were abandoned because of the prevention of ovarian hyperstimulation (OHSS), and 78 cases of transplantation cycle patients di...

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PUM

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Abstract

The invention discloses a medicinal composition, which comprises Chinese medicinal materials 30-99.9% of the total weight of the composition, and pharmaceutically acceptable carries in balancing amount. The Chinese medicinal materials include the following Chinese traditional medicines by weight: (a) 15-90 parts of Chinese medicinal materials for providing sperms motion energy, (b) 15-60 parts of Chinese medicinal materials for strengthening adenosine triphosphate, (c) 70-330 parts of Chinese medicinal materials for providing antioxidation effect, (d) 10-50 parts of Chinese medicinal materials for promoting sperms generation, (e) 10-40 parts of Chinese medicinal materials for regulating internal secretion, and (f) 20-80 parts of Chinese medicinal materials for invigorating qi and strengthening spleen. The invention also discloses a preparation method and an application thereof.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine composition, more specifically, a traditional Chinese medicine composition or dietary supplement for treating infertility and a preparation method thereof. Background technique [0002] According to the World Health Organization (WHO) survey, 15% of couples of childbearing age in the world have infertility problems; 8%-22% of them are completely attributable to men, and 21%-38% are related to both couples, so it can be considered that about 50% of the infertility factors involve men. About 1 / 10 couples in China are infertile, and about 40% are male factors. [0003] Since the 20th century, due to factors such as environmental pollution, the spread of sexually transmitted diseases, excessive smoking, drug abuse, and hormone abuse, male fertility has shown a significant downward trend worldwide. Studies have shown that the causes of male infertility include endocrine diseases, testicular s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K36/8969A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P15/08A61K35/56A61K35/586
Inventor 张慧琴施惠娟宣文虎赵洪鑫贾晓峰张文静冯云张爱军
Owner SHANGHAI INST OF PLANNED PARENTHOOD RES
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