Compound lincomycin hydrochloride injection for livestock and preparation method thereof

Abstract

The invention relates to a compound lincomycin hydrochloride injection for livestock. The compound lincomycin hydrochloride injection is characterized in that the compound lincomycin hydrochloride injection is prepared through evenly mixing the following compositions in weight portion: 8 to 20 portions of lincomycin hydrochloride, 5 to 20 portions of berberine bisulfate, 5 to 15 portions of gentamicin sulfate-micronomicin sulfate and 45 to 100 portions of water for injection. The preparation method comprises the following steps: (1) according to weight portion, 8 to 20 portions of the lincomycin hydrochloride, 5 to 20 portions of the berberine bisulfate and 5 to 15 portions of the gentamicin sulfate-micronomicin sulfate are weighed; (2) the lincomycin hydrochloride is put into 30 to 40 portions of the water for injection at a temperature of between 45 and 55 DEG C and is stirred for 10 to 25 minutes to clarification; (3) 10 to 20 portions of the water for injection is taken out, is sequentially added with 5 to 15 portions of the gentamicin sulfate-micronomicin sulfate and 5 to 20 portions of the berberine bisulfate and is stirred and dissolved; and (4) a solution prepared in the step 2 and a solution prepared in the step 3 are mixed, are evenly stirred and are kept for 15 to 20 minutes; and after a medicine solution is clarified, the residual part of the water for injection is added into the medicine solution and is evenly stirred and filtered. The compound lincomycin hydrochloride injection has a reasonable formula, simple preparation and remarkable curative effect.

Description

technical field [0001] The invention relates to a drug injection for livestock and a preparation method thereof, in particular to a compound lincomycin hydrochloride injection for livestock and a preparation method thereof. Background technique [0002] Leptospirosis is a common zoonotic infectious disease caused by Leptospira, with complex and diverse clinical symptoms, such as fever, jaundice, hemoglobinuria, skin and mucous membrane necrosis, edema, and abortion in pregnant animals, among which pigs, cattle, Sheep, dogs, and humans are most at risk. [0003] The main pathogen of the disease is Leptospira, and the disease spreads to nearly a hundred countries on five continents. For decades, oxytetracycline, chloramphenicol, penicillin, streptomycin, quinolones and other drugs have been included in the first choice drugs for the treatment of this disease all over the world, including my country. Due to long-term repeated use of an antibiotic or antibacterial drug , causin...

AI Technical Summary

Problems solved by technology

For decades, oxytetracycline, chloramphenicol, penicillin, streptomycin, quinolones and other drugs have been included in the first choice drugs for the treatment of this disease all over the world, including my country. Due to long-term repeated use of an antibiotic or antibacterial drug , resulting in the resistance of the pathogenic microorganisms to the drug, reducing the curative effect and increasing the drug residue