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Compound lincomycin hydrochloride injection for livestock and preparation method thereof

A technology for lincomycin hydrochloride and injection, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc. Reasonable and effective effect

Inactive Publication Date: 2009-04-22
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, oxytetracycline, chloramphenicol, penicillin, streptomycin, quinolones and other drugs have been included in the first choice drugs for the treatment of this disease all over the world, including my country. Due to long-term repeated use of an antibiotic or antibacterial drug , resulting in the resistance of the pathogenic microorganisms to the drug, reducing the curative effect and increasing the drug residue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A compound lincomycin hydrochloride injection for livestock and a preparation method thereof, is characterized in that it is carried out as follows: (each part is calculated by 10g)

[0021] (1) Take by weight parts of lincomycin hydrochloride 80g, berberine sulfate 50g, genta-micronomycin 50g;

[0022] (2) Put the lincomycin hydrochloride into 300 g of 50° C. water for injection, and stir for 10 to 25 minutes until clear;

[0023] (3) Get water for injection 100g, add the genta-micronomycin sulfate, berberine sulfate of described parts weight successively, stir and dissolve;

[0024] (4) Combine the solutions prepared in the above steps (2) and (3), stir evenly, keep for 15-20 minutes, add water for injection to 500g after the liquid medicine is clear, stir evenly and filter.

Embodiment 2

[0026] A compound lincomycin hydrochloride injection for livestock and a preparation method thereof, is characterized in that it is carried out as follows: (each part is calculated by 10g)

[0027] (1) Take by weight parts of lincomycin hydrochloride 150g, berberine sulfate 100g, genta sulfate-micronomycin 50g;

[0028] (2) Put the lincomycin hydrochloride into 400 g of 40° C. water for injection, and stir for 10 to 25 minutes until clear;

[0029] (3) Get 200g of water for injection, add successively the genta-micronomycin sulfate, berberine sulfate of described parts weight, stir and dissolve;

[0030] (4) Combine the solutions prepared in the steps (2) and (3) above, stir evenly, keep for 15-20 minutes, add water for injection to 700g after the liquid is clear, stir evenly and filter.

Embodiment 3

[0032] A compound lincomycin hydrochloride injection for livestock and a preparation method thereof, is characterized in that it is carried out as follows: (each part is calculated by 10g)

[0033] (1) Take by weight lincomycin hydrochloride 200g, berberine sulfate 200g, genta sulfate-micronomycin 150g;

[0034] (2) Put the lincomycin hydrochloride into 400 g of 55° C. water for injection, and stir for 10 to 25 minutes until clear;

[0035] (3) Get 200g of water for injection, add successively the genta-micronomycin sulfate, berberine sulfate of described parts weight, stir and dissolve;

[0036] (4) Combine the solutions prepared in the above steps (2) and (3), stir evenly, keep for 15-20 minutes, add water for injection to 1000g after the liquid medicine is clear, stir evenly and filter.

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PUM

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Abstract

The invention relates to a compound lincomycin hydrochloride injection for livestock. The compound lincomycin hydrochloride injection is characterized in that the compound lincomycin hydrochloride injection is prepared through evenly mixing the following compositions in weight portion: 8 to 20 portions of lincomycin hydrochloride, 5 to 20 portions of berberine bisulfate, 5 to 15 portions of gentamicin sulfate-micronomicin sulfate and 45 to 100 portions of water for injection. The preparation method comprises the following steps: (1) according to weight portion, 8 to 20 portions of the lincomycin hydrochloride, 5 to 20 portions of the berberine bisulfate and 5 to 15 portions of the gentamicin sulfate-micronomicin sulfate are weighed; (2) the lincomycin hydrochloride is put into 30 to 40 portions of the water for injection at a temperature of between 45 and 55 DEG C and is stirred for 10 to 25 minutes to clarification; (3) 10 to 20 portions of the water for injection is taken out, is sequentially added with 5 to 15 portions of the gentamicin sulfate-micronomicin sulfate and 5 to 20 portions of the berberine bisulfate and is stirred and dissolved; and (4) a solution prepared in the step 2 and a solution prepared in the step 3 are mixed, are evenly stirred and are kept for 15 to 20 minutes; and after a medicine solution is clarified, the residual part of the water for injection is added into the medicine solution and is evenly stirred and filtered. The compound lincomycin hydrochloride injection has a reasonable formula, simple preparation and remarkable curative effect.

Description

technical field [0001] The invention relates to a drug injection for livestock and a preparation method thereof, in particular to a compound lincomycin hydrochloride injection for livestock and a preparation method thereof. Background technique [0002] Leptospirosis is a common zoonotic infectious disease caused by Leptospira, with complex and diverse clinical symptoms, such as fever, jaundice, hemoglobinuria, skin and mucous membrane necrosis, edema, and abortion in pregnant animals, among which pigs, cattle, Sheep, dogs, and humans are most at risk. [0003] The main pathogen of the disease is Leptospira, and the disease spreads to nearly a hundred countries on five continents. For decades, oxytetracycline, chloramphenicol, penicillin, streptomycin, quinolones and other drugs have been included in the first choice drugs for the treatment of this disease all over the world, including my country. Due to long-term repeated use of an antibiotic or antibacterial drug , causin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61P31/00A61K31/4375A61K31/7036
Inventor 王连民刘文利
Owner TIANJIN SHENGJI GRP CO LTD
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