Administration bracket for uterus neck

A drug delivery and site technology, applied in the field of drug delivery stents containing photosensitive drugs

Inactive Publication Date: 2009-05-06
上海复旦张江生物医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Up to now, there has not been found a drug delivery stent whose drug is a photosensitive substance, whose shape is more appropriate to the physiological structure of the cervix, and which can be attached to the cervix (including the cervical canal) for a long time and continuously release the drug.

Method used

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  • Administration bracket for uterus neck
  • Administration bracket for uterus neck
  • Administration bracket for uterus neck

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dissolve 4g of carboxymethyl chitosan in 100ml of distilled water and stir for 1 hour, then add 4g of gelatin and stir for 2 hours, then add 1g of glycerin and stir for 2 hours, then add hyaluronic acid and stir for 2 hours, and finally slowly add 1.25g of 5- Aminolevulinic acid hydrochloride was stirred until dissolved. After standing until there are no air bubbles, pour it into the stereotyped mold at -40°C for 4 hours, freeze-dry it for 4 hours, raise the temperature to minus 10°C and maintain it for 16 hours, then raise the temperature to 20°C for 3 hours, and shape it. Nearly 50 structures such as figure 2 The single-layer drug delivery stent.

Embodiment 2

[0038] Dissolve 4g of carboxymethyl chitosan in 100ml of distilled water and stir for 1 hour, then add 4g of gelatin and stir for 2 hours, then add 1g of glycerin and stir for 2 hours, then add hyaluronic acid and stir for 2 hours, and finally slowly add 2.5g of 5 - Aminolevulinic acid hydrochloride was stirred until dissolved. After standing until there are no air bubbles, pour it into the stereotyped mold at -40°C for 4 hours, freeze-dry it for 4 hours, raise the temperature to minus 10°C and maintain it for 16 hours, then raise the temperature to 20°C for 3 hours, and shape it. Nearly 50 structures such as figure 2 The single-layer drug delivery stent.

Embodiment 3

[0040] Dissolve 0.2g of carboxymethyl chitosan in dichloromethane, pour it into the shaping mold, freeze-dry for 6 hours and put it into a special shaping mold as the inner layer; then dissolve 4g of carboxymethyl chitosan in 100ml of distilled water After stirring for 1 hour, add 4g of gelatin and stir for 2 hours, then add 1g of glycerin and stir for 2 hours, then add hyaluronic acid and stir for 2 hours, and finally add 15g of 5-aminolevulinic acid hydrochloride slowly and stir until dissolved. After standing still until there are no air bubbles, pour it into the shaping mold, freeze at -40°C for 4 hours, raise the temperature to minus 10°C for 16 hours, and raise the temperature to 20°C for 3 hours, and form a composite layer with the inner layer, making nearly 50 structures such as image 3 The composite layer drug delivery stent.

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PUM

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Abstract

The invention relates to the technical field of medical appliance, in particular to a photosensitive drug dosing bracket used for curing uterine neck pathological changes, which provides a dosing bracket used for uterine necks and comprises a support structure with a coating on the surface. The bracket is characterized in that the coating contains photosensitive substance. The dosing bracket used for uterine neck pathological changes can be attached with the uterine necks in compliance so as to ensure that photodynamic therapy medicine can be continuously released on focus parts. The dosing bracket is convenient for the use of medical personnel and improves the comfort of patients.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a drug delivery stent containing photosensitizing drugs for treating cervical lesions. Background technique [0002] Human papillomavirus (HPV) infection often leads to a variety of gynecological diseases, especially cervical lesions, including: cervicitis, cervical epithelial neoplasia (CIN), cervical cancer, etc., which are common and frequently-occurring diseases in gynecology. [0003] Photodynamic therapy is a brand-new medical method that emerged in the 1990s and is now one of the statutory tumor treatment methods approved by the FDA. Its main mechanism is to irradiate the lesion with light of a specific wavelength to stimulate the photosensitive substances (endogenous or external) in the tissue or cells of the lesion to undergo a photochemical reaction and generate a large number of oxygen free radicals, thereby killing the diseased cells. This therapy can be widel...

Claims

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Application Information

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IPC IPC(8): A61M31/00
Inventor 曹峰苏勇任晓岚
Owner 上海复旦张江生物医药股份有限公司
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