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Chitosan hydrogel as well as preparation method and application thereof

A technology of chitosan and hydrogel, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of secondary inflammation of skin tissue and other problems, and achieve excellent Anti-inflammatory effect, reduce secondary inflammatory reaction, and promote repair effect

Pending Publication Date: 2021-11-09
中科宸星杭州科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Because the current chitosan hydrogel cannot solve the problem of secondary inflammation after skin tissue damage

Method used

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  • Chitosan hydrogel as well as preparation method and application thereof
  • Chitosan hydrogel as well as preparation method and application thereof
  • Chitosan hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Present embodiment provides a kind of chitosan hydrogel, preparation method is as follows:

[0039] (1) Chitosan was dissolved in 1% acetic acid solution (mass ratio 3:100) by volume fraction, and then mixed with N-acetylneuraminic acid and polysialic acid (mass ratio 1:1) (molar ratio: shell Glycan monomer: (N-acetylneuraminic acid and polysialic acid) = 10:1), cycle freezing (freezing temperature -20°C, time 12h, thawing temperature 25°C, time 12h) 3 times to obtain the preliminary test hydrogel ;

[0040] (2) Place the initial test hydrogel obtained in step (1) in a 2- (N-Morpholino) ethanesulfonic acid mixed solution (molar ratio is 1:1:10, adjust pH to be 6) incubate 12h, obtain described chitosan hydrogel through 1M sodium hydroxide solution elution afterwards, its Electron microscope photos such as figure 1 As shown, the infrared spectrum as figure 2 shown. figure 2 Appears in 1641cm -1 at 1567cm -1 Corresponding to the stretching vibration absorption pe...

Embodiment 2

[0042]Present embodiment provides a kind of chitosan hydrogel, preparation method is as follows:

[0043] (1) Chitosan is dissolved in the acetic acid solution (mass ratio 2.5:100) of volume fraction 0.8%, then mixes with N-acetylneuraminic acid (molar ratio: chitosan monomer: N-acetylneuraminic acid =9:1), cycle freezing (freezing temperature -20°C, time 12h, thawing temperature 25°C, time 12h) 4 times to obtain the preliminary test hydrogel;

[0044] (2) Place the initial test hydrogel obtained in step (1) in a 2- (N-Morpholino) ethanesulfonic acid mixed solution (molar ratio 1:1:10, pH adjusted to 5.5) was incubated for 11 h, and then rinsed with 1M sodium hydroxide solution to obtain the chitosan hydrogel.

Embodiment 3

[0046] Present embodiment provides a kind of chitosan hydrogel, preparation method is as follows:

[0047] (1) Chitosan is dissolved in the acetic acid solution (mass ratio 3.5:100) of volume fraction 1.2%, then mixes with protocatechuic acid (molar ratio: chitosan monomer: protocatechuic acid=11:1 ), cycle freezing (freezing temperature -20°C, time 12h, thawing temperature 25°C, time 12h) 4 times to obtain the preliminary test hydrogel;

[0048] (2) Place the initial test hydrogel obtained in step (1) in a 2- (N-Morpholino) ethanesulfonic acid mixed solution (molar ratio 1:1:10, pH adjusted to 5.5) was incubated for 11 h, and then rinsed with 1M sodium hydroxide solution to obtain the chitosan hydrogel.

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Abstract

The invention provides chitosan hydrogel as well as a preparation method and application thereof, the preparation method of the chitosan hydrogel comprises the following steps: (1) dissolving chitosan in an acid solution, then mixing with an anti-inflammatory agent, and circularly freezing to obtain primary test hydrogel; and (2) placing the primary test hydrogel obtained in the step (1) in a 2-(N-morpholino) ethanesulfonic acid mixed solution of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide for incubation, then treating the primary test hydrogel with an alkali solution, and washing the primary test hydrogel with deionized water to obtain the chitosan hydrogel. The chitosan hydrogel provided by the invention is good in anti-inflammatory effect and good in skin tissue injury repairing effect.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a chitosan hydrogel and its preparation method and application, in particular to a chitosan hydrogel with good anti-inflammatory effect and its preparation method and application. Background technique [0002] Hydrogel is a kind of aggregate of hydrophilic polymer and water between solid state and liquid state with three-dimensional space. Hydrogels have good mechanical properties, biocompatibility and biodegradability, and their wet and soft surface and liquid-filled internal environment are conducive to cell adhesion, proliferation and differentiation, and are easy to use specific biomolecules for surface modification such as Loaded with drugs and growth factors, these properties make it an ideal biomaterial for skin tissue repair. In addition, in the field of food industry, hydrogel can effectively control the release of flavor substances, reduce the water activity of food in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K47/69A61K31/192A61K31/351A61K31/715A61P7/02A61P29/00
CPCA61K47/61A61K47/6903A61K31/351A61K31/192A61K31/715A61P7/02A61P29/00A61K2300/00
Inventor 陈祥松吴金勇袁丽霞葛远飞王相勤姚建铭
Owner 中科宸星杭州科技有限公司
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