Conjugates of aziridinyl-epothilone analogs and pharmaceutical compositions comprising same

A heterocycloalkyl compound technology, applied in the field of aziridinyl-epothilone analog conjugates and pharmaceutical compositions containing them, can solve the problem of attacking normal tissues, uneven distribution of antigens, and host toxicity drop and other issues
CN101495154AInactive Publication Date: 2009-07-29BRISTOL MYERS SQUIBB CO +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BRISTOL MYERS SQUIBB CO
Publication Date
2009-07-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to conjugated compounds comprising a folate, or an analog or derivative thereof, and an aziridinyl epothilone analog, as further described herein, and / or pharmaceutically-acceptable salts and / or solvates thereof, useful in the treatment of cancer or other folate-receptor associated conditions.
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Description

[0001] This application claims priority to US Provisional Patent Application 60 / 808,367, filed May 25, 2006, which is hereby incorporated by reference in its entirety. technical field

[0002] The present invention relates to conjugates (conjugates) of aziridinyl-epothilone analogs (aziridinyl-epothilone analogs), more specifically to folate group conjugation of aziridinyl-epothilone analogs Folate conjugates, to pharmaceutical compositions comprising said conjugates, and to methods of using said conjugates and pharmaceutical compositions. Background technique

[0003] Epothilone A and Epothilone B A naturally occurring compound isolated from the fermentation product of the microorganism Sorangium cellulosum discovered by et al. (see eg WO 93 / 10121). also found 37 natural epothilone variants and related compounds produced by S. cellulosus, including epothilone C, D, E, F and other isomers and variants. See, eg, US Patent No. 6,624,310. in 1993 et al reported the cytot...

Claims

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