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Compound qinlan oral liquid

A technology of compound Qinlan oral liquid and Qinlan oral liquid, which is applied in the fields of pharmaceutical formulations, plant raw materials, respiratory diseases, etc., can solve problems such as unfavorable baicalin extraction, and achieve the effect of improving stability, simple and efficient operation

Inactive Publication Date: 2009-09-16
HEILONGJIANG ZBD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the main problem that this method exists is when honeysuckle, scutellaria baicalensis, forsythia, Radix Radix four flavor medicinal materials are mixed and extracted, because chlorogenic acid (3-caffeoylquinic acid) and isochlorogenic acid (5-caffeoylquinic acid) in honeysuckle The presence of quinic acid) makes the extracts slightly acidic, and this acidic environment is not conducive to the extraction of baicalin (flavonoids are easy to precipitate under acidic conditions)

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0022] Example 1 Separate extraction of Scutellaria baicalensis

[0023] First, take 50g of Scutellaria baicalensis, add 400ml, 300ml, and 300ml of water to decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoctions, filter, and then add 2mol / L hydrochloric acid at 80°C Adjust the pH value of the solution to 2.0 in an appropriate amount, keep it warm for 1 hour, let it stand for 12 hours, and filter to collect the precipitate; then add water 6 times the weight of the precipitate, and adjust the pH value to 7.0 with 40% sodium hydroxide, then add an equal volume of ethanol, and stir to make the precipitate Dissolve and filter, adjust the pH value of the filtrate to 2.0 with 2mol / L hydrochloric acid solution, keep it at 60°C for 30 minutes, let it stand for 12 hours, and filter; finally, wash the precipitate with ethanol until the pH value is 7.0, and the obtained product is a semi-finished product, and the content of baical...

Embodiment 2

[0029] Medicinal materials: Honeysuckle 500g, Scutellaria baicalensis 500g, Forsythia 1000g, Radix Radix 500g.

[0030] Preparation method: First, take the cleaned Scutellaria baicalensis and add 4000ml, 3000ml, and 3000ml of water to decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoctions and filter, then add 2mol / L at 80°C Adjust the pH value of the hydrochloric acid solution to 1.0 and keep it warm for 1 hour, filter after standing for 12 hours, then add 6 times the precipitation weight of water to the precipitate, and adjust the pH value to 7.0 with 40% sodium hydroxide solution, then add an equal volume of ethanol , stir to dissolve the precipitate and filter, adjust the pH value of the filtrate to 2.0 with 2mol / L hydrochloric acid solution, keep it warm at 60°C for 30min, let it stand for 12h and then filter, wash the precipitate with ethanol until the pH value is 7.0, and obtain the extract 1, Ethanol can be rec...

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Abstract

The invention relates to a compound qinlan oral liquid which includes an extractor from honeysuckle, forsythia, radix isatidis and radix scutellariae. A method for preparing the oral liquid includes steps as follows: extracting radix scutellariae by using method of acid precipitation; processing combining decocting to honeysuckle, forsythia and radix isatidis; combining the extract of above component, adding suitable assistant material after cooling processing, adding water and boiling, then adjusting PH value to 6.8-7.2, filtering, filling and sterilizing, finially obtaining the compound qinlan oral liquid. The preparing method can increase transfer rate of scutelloside, accordingly, increase scutelloside content in the preparation. The compound qinlan oral liquid has more stable quality.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and more specifically relates to a compound Qinlan oral liquid. Background technique [0002] Honeysuckle, scutellaria, forsythia and isatis root are traditional Chinese medicines commonly used in clinical practice in China, all of which have the effect of clearing away heat and detoxifying. Modern pharmacological studies have shown that honeysuckle has antibacterial, antiviral, anti-inflammatory, antipyretic, and immune-regulating effects; Scutellaria baicalensis has the effects of clearing away heat and dampness, detoxifying, cooling blood, and purging lung fire; Forsythia has antibacterial, heart-strengthening, and diuretic effects. It can be used to treat acute wind-heat cold, carbuncle sore, lymph node tuberculosis and other diseases; while Radix Radix has the functions of clearing heat and detoxification, cooling blood and relieving throat. Combining honeysuckle, forsythia, scu...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61P11/04A61P11/14A61P29/00A61P31/12
Inventor 方同华项彦华岳大彪周雪峰王春生周广红阮金霞
Owner HEILONGJIANG ZBD PHARMA
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