Tricyclic compounds

Abstract

The invention discloses tricyclic compounds of the right formula.

Description

technical field The present invention provides a process for the preparation of intermediates useful in the preparation of known tricyclic compounds which are inhibitors of farnesyl protein transferase. In particular, the compounds prepared by the methods of the present invention are useful as chiral intermediates for the preparation of chiral compounds of FPT inhibitors disclosed in PCT Publication No. WO 97 / 23478 on July 3, 1997. Background technique Over the past few decades, a number of enantioselective carbon-carbon bond-forming reactions have been developed, which can be divided into two distinct classes—one involving the alkylation of covalently bonded chiral precursors and the other Use non-covalent chiral auxiliaries. Examples of the former include Evan's oxazolidinone system, Meyer's oxazoline system and Ender's RAMP / SAMP system. (See Evans, D.A., et al., Encyclopedia of Reagents for Organic Synthesis; Wiley: Chichester, 1995, Vol.1, p.345; Gant, T.G.; Meyers, A....

AI Technical Summary

Problems solved by technology

Gawley reported that α-aminoorganolithium anions generated from chiral stannane precursors are conformationally stable, although in some cases alkylation with primary alkyl halides yields with excellent enantiomeric selective product, but the method is affected by the fact that the chiral tin precursor must be decomposed

Images