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A technology of total alkaloids and alkaloids, applied in the fields of application, medical preparations containing active ingredients, food science, etc., can solve problems such as information about drug extraction and application, unclear active ingredients and mechanism of action, etc.
Inactive Publication Date: 2009-10-14
HENAN UNIV OF SCI & TECH
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[0005] In recent years, studies have shown that the bark of Eucommia ulmoides and its seeds, leaves, and flowers have sedative and hypnotic effects, but the specific active ingredients and mechanism of action in Eucommia ulmoides are still unclear. So far, no drugs have been extracted from the effective parts of Eucommia ulmoides functional components. Information on its application in the field of sedation-hypnosis
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Embodiment 1
[0029] Example 1 Study on hypnotic sedative activity of Eucommia ulmoides total alkaloids:
[0030] 1. Materials and equipment
[0031] 1.1 Main materials and reagents
[0032] Eucommia: taken from the Eucommia plantation base in XX county, XX city; pentobarbital sodium, Sigma company Shanghai sub-packaged product; Nicosame, 0.9% sodium chloride solution, diazepam, Shanghai Shiyi Chemical Reagent Co., Ltd.
[0033] 1.2 Main instruments and equipment
[0034] GJ-1 photoelectric counter, Tianjin Medical Equipment Repair Factory.
[0035] 1.3 Experimental animals
[0036] Kunming mice, ordinary grade, 20-30g (male), provided by the Animal Experiment Center of Henan University of Science and Technology.
[0037] 2. Test method
[0038] 2.1 Effects on autonomous activities of mice:
[0039] Animal grouping: Before the experiment, put the mice into the activity box of the GJ-1 photoelectric counter, start the recorder to record the number of activities within 5 minutes, and select norma...
Embodiment 2
[0069] Example 2 Preparation of health medicinal tea:
[0070] Add 3 grams of total alkaloids from Eucommia ulmoides to 50 kilograms of tea leaves (choose one from black tea, green tea and scented tea), mix well, transfer to a pulverizer to make the particle size of the material 15-30 mesh, add 47 kilograms of compound sweetener, and mix thoroughly Pack it into a special paper bubble bag, coat an aluminum-plastic composite bag, and seal it, each bag is 5-8 grams, to make a sedative hypnotic health tea.
Embodiment 3
[0071] Example 3 Preparation of health-care granules:
[0072] Take the total alkaloids of Eucommia ulmoides obtained by extraction and separation, mix them with appropriate amount of juice powder, sugar and other auxiliary agents, pass through a 12-mesh sieve, dry at 75°C, and package them into bags to make various granules with sedative and hypnotic effects. Each bag contains biological Alkali 100 mg.
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Abstract
The invention discloses applications of an eucommia ulmoide total alkaloid for preparing a combination with a sedative-hypnotic effect, and also discloses applications of the eucommia ulmoide total alkaloid for preparing the combination used for treatment of insomnia, anxiety or convulsion; the eucommia ulmoide total alkaloid is prepared by extracting, separating and purifying an eucommia ulmoidespark, an eucommia ulmoide leaf, an eucommia ulmoide male flower and / or eucommia ulmoide whole-plant. The invention extracts, separates and purifies the plant eucommia ulmoide. The invention obtains the eucommia ulmoide total alkaloid by extracting, separating and purifying plant eucommia ulmoide and carries out the application research of the eucommia ulmoide total alkaloid in the sedative-hypnotic field; the result indicates that the eucommia ulmoide total alkaloid has obvious sedative-hypnotic effect and anti-convulsion effect, is a natural active matter for researching and developing a novel health-caring food and new drugs with the sedative-hypnotic effect, can be used for curing the nervous system diseases such as insomnia, anxiety or convulsion and has no side effects or spiritual dependency.
Description
Technical field [0001] The invention relates to an application of Eucommia ulmoides total alkaloids. Background technique [0002] Insomnia is a clinically multiple disease with complex causes and recurring attacks. At present, the sedative and hypnotic drugs of western medicine commonly used at home and abroad have certain side effects and dependence. The sedative and hypnotic effects of Chinese medicine have become a hot spot in recent years. [0003] Eucommia (Eucommia ulmoides Oliv.), a deciduous tree, belongs to the Pinus genus Pinus; branchlets are smooth, yellowish brown or lighter, with lamellar pith, bark, branches and leaves all contain colloid; single leaves alternate, oval or egg Shape, apex acuminate, broadly wedge-shaped at the base, with serrated edges, young leaves are sparsely pilose on the top, denser on the bottom, smooth on the top of the old leaves, and sparsely coated on the veins below; the flowers are unisexual, dioecious, and at the same time as the leave...
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