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Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof

A composition and drug technology, applied in the field of pharmaceutical composition and preparation and quality control for the treatment of rheumatoid arthritis, can solve problems such as internal organ damage, failure to fundamentally treat, and damage to the human immune system

Active Publication Date: 2009-11-04
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Western medicine mainly uses drugs such as non-steroidal anti-inflammatory drugs, immunosuppressants and hormones in the treatment of rheumatoid arthritis at present. Medication may also damage the immune system of the human body, and eventually irreversible severe damage to internal organs such as the stomach, liver, and kidneys will occur. The side effects must not be ignored

Method used

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  • Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof
  • Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof
  • Medical composition for treating rheumatoid arthritis and preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0059] The technological research of experimental example 1 tablet

[0060] water volume

[0061] Prepare 3 medicinal materials according to the prescription: Cortex Phellodendron, Rhizoma Drynariae (made), Guangdilong, Achyranthes bidentata, Maple Bark, Geranium, Wujiapi, Dipsacus, Epimedium, Ephedra, Licorice, and Mistletoe, divided into three parts The first group added 6 times, 4 times, and 4 times the amount of water, the second group added 8 times, 6 times, and 6 times the amount of water, and the third group added 10 times, 8 times the amount of water , 8 times the amount, the amount of water added is determined based on the amount of cream produced. The results are shown in Table 1:

[0062] Table 1: Amount of water added for water extraction

[0063]

[0064] Taking the amount of cream output as an indicator, it can be seen that adding 8 times, 6 times, and 6 times of water is better, and the amount of water added is 8 times, 6 times, and 6 times in production.

...

experiment example 2

[0070] Experimental example 2 The identification method test of ginseng

[0071] (1) The extraction solvent selection of need testing solution

[0072] The extraction solvent selection method of the test solution a. Get 25 pieces of the finished product in Example 12, remove the sugar coating, grind finely, add 25ml of ether, ultrasonically treat for 15 minutes, filter, evaporate the solvent from the dregs, add water to saturate Alcohol 50ml, sonicated for 30 minutes, filtered, the filtrate was extracted with 30ml of ammonia test solution, the lower layer was discarded, washed with 20ml of water, the water layer was discarded, n-butanol was recovered to dryness, the residue was dissolved by adding 1ml of methanol, and used as the test solution. product solution.

[0073] The extraction solvent selection method b of the test solution is to get 25 pieces of the finished product in Example 12, remove the sugar coating, grind finely, add 50 ml of water-saturated n-butanol, ultras...

experiment example 3

[0104] Experimental example 3 the identification method test of honeysuckle

[0105] (1) The extraction solvent selection of need testing solution

[0106] The extraction solvent selection method of the test solution a. Take the finished product in Example 12, remove the sugar coating, grind it finely, weigh 1.4g, add petroleum ether (30-60°C) 3ml, soak for 30min, and take the supernatant as the test solution product solution.

[0107] The extraction solvent selection method of need testing solution b. get the finished product of embodiment 12 and remove sugar coating, grind finely, take by weighing 1.4g, add methyl alcohol 5ml, leave 12 hours, filter, get filtrate as need testing solution.

[0108] The extraction solvent selection method of need testing solution c. get the finished product of embodiment 12 and remove sugar coating, grind finely, take by weighing 1.4g, add 50% methanol 25ml ultrasonic treatment 30 minutes, filter, get filtrate as need testing solution .

[...

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Abstract

The invention discloses a medical composition for treating rheumatoid arthritis and a preparation method and a quality control method thereof. The medical composition comprises raw materials of raw radix aconite, raw radix aconiti agrestis, dog button (prepared), notopterygium root, black snake, radices pseudoginseng, rhizoma drynariae (prepared), ebony, honeysuckle, asarum, ginseng, cornucervi pantotrichum, amoorcorn tree bark, myrrh, lumbricus, anisetree bark, cranesbill, acanthopanax bark, Dipsacus japonicus Miq., Ephdra sinica Stapf, liquorice, mistletoe, epimedium, achyranthes and cassia twig. The preparation method comprises following steps: the 12 medicines of amoorcorn tree bark, rhizoma drynariae, lumbricus, achyranthes, anisetree bark, cranesbill, acanthopanax bark, Dipsacus japonicus Miq., epimedium, Ephdra sinica Stapf, liquorice and mistletoe are decocted once to thrice, the decoction is combined and is filtered to be concentrated to obtain clear paste A; other 13 medicines of raw radix aconite, raw radix aconiti agrestis, and the like are pulverized to be fine powder, and the fine powder is screened to obtain medicinal powder B; and the medical composition is prepared after evenly mixing the clear paste A and the medicinal powder B.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method, in particular to a pharmaceutical composition for treating rheumatoid arthritis, a preparation method and a quality control method. Background technique [0002] Rheumatoid arthritis is an allergic disease and is one of the main manifestations of rheumatic fever. It usually starts with acute fever and joint pain. The typical manifestations are mild or moderate fever and migratory polyarthritis. The affected joints are mostly large joints such as knees, ankles, shoulders, elbows, and wrists. It is common to transfer from one joint to the other. In another joint, the lesion is locally red, swollen, burning, and painful. Some patients also have several joints at the same time. The acute inflammation usually subsides in 2-4 weeks without sequelae, but it often recurs. If rheumatic activity affects the heart, myocarditis can occur, and even left over h...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P29/00A61P19/02G01N30/36G01N30/90A61K35/32A61K35/58A61K35/64A61K35/583A61K35/62
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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