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Kendir pressure-reducing sticking agent and preparation method thereof

A kind of Apocynum, transdermal patch technology, applied in the field of pharmaceutical preparations, can solve the problems of skin sensitization, molding process limits the development of traditional Chinese medicine patches, large drug loading, etc.

Active Publication Date: 2010-01-06
北京化药科创医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the field of traditional Chinese medicine preparations, the molding process of patches has always limited the development of traditional Chinese medicine patches.
The process standard of Apocynum antihypertensive tablets is to crush mother-of-pearl, Alisma, and Uncaria into fine powder, decoct Apocynum, Prunella, and chrysanthemum twice in water to remove the decoction extract; extract, and then combine the fine powder and two different water-decocted extracts to compress the tablet and report sugar-coating to get it. This process is directly used for Apocynum antihypertensive patch, which has too much drug loading and is not easy to shape , and because there are many allergic magazine macromolecules, etc., when pasted on the skin for a long time, it is easy to cause some adverse events such as skin sensitization

Method used

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  • Kendir pressure-reducing sticking agent and preparation method thereof
  • Kendir pressure-reducing sticking agent and preparation method thereof
  • Kendir pressure-reducing sticking agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Preparation of patch

[0016] prescription

[0017] Apocynum 370g, Prunella vulgaris 80g, Uncaria 80g, Alisma 70g, mother-of-pearl 50g, Achyranthes bidentata 50g, hawthorn 50g, chrysanthemum 50g

[0018] Polyvinyl alcohol 20g, gelatin 30g, kaolin 3g, glycerin 150g, azone 40g

[0019] Preparation Process:

[0020] (1) Preparation of the active ingredient of the crude drug: mother of pearl is pulverized, passed through a 120 mesh sieve, and set aside; the medicinal materials Apocynum apocynum, Prunella vulgaris, Alisma, hawthorn and chrysanthemum are respectively pulverized into coarse powder, mixed evenly, and mixed with 70% The ethanol reflux extracts 3 times, each 2 hours, filters, and merges extract, and filtrate reclaims ethanol under reduced pressure, concentrates to the thick ointment that relative density is 1.20, and thick ointment adds 95% ethanol, fully stirs, and makes medicinal solution contain The alcohol content is 80%, stand still, filter, take the supe...

Embodiment 2

[0024] Preparation of patch

[0025] prescription

[0026] Apocynum 300g, Prunella vulgaris 100g, Uncaria 100g, Alisma 100g, mother-of-pearl 30g, Achyranthes bidentata 30g, hawthorn 30g, chrysanthemum 30g

[0027] Polyvinyl alcohol 10g, gelatin 20g, kaolin 1g, glycerin 300g, azone 50g

[0028] Preparation Process:

[0029] (1) Preparation of the active ingredient of the crude drug: mother of pearl is pulverized, passed through a 120-mesh sieve, and set aside; the medicinal materials Apocynum apocynum, Prunella vulgaris, Alisma, hawthorn and chrysanthemum are respectively pulverized into coarse powder, mixed evenly, and mixed with 60% The ethanol reflux extracts 2 times, each 3 hours, filters, and merges extracting solution, and filtrate reclaims ethanol under reduced pressure, concentrates to the thick ointment that relative density is 1.10, and thick ointment adds 95% ethanol, fully stirs, and makes medicinal solution contain The alcohol content is 60%, stand still, filter...

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Abstract

The invention relates to a kendir pressure-reducing sticking agent and a preparation method thereof. The preparation method comprises the following steps: extracting eight kinds of medicinal materials of kendir, self-heal, uncaria stem with hooks, rhizoma alismatis, mother-of-pearl, twotooth achyranthes root, hawthorn and chrysanthemum which are raw material medicines, refining the effective components of the medicinal materials, adding an excipient, polyvinyl alcohol, gelatin, kaolin, glycerol and azone and preparing to obtain the kendir pressure-reducing sticking agent. The kendir pressure-reducing sticking agent obtained by the invention has slow medicine release, stable drug administration, strong pressure-reducing effect, small stimulation and no toxic or side effect.

Description

technical field [0001] The present invention relates to an antihypertensive external medicine preparation, in particular to a patch made of raw medicinal materials Apocynum apocynum, Prunella vulgaris, Uncaria, Alisma, mother of pearl, Achyranthes bidentata, hawthorn and chrysanthemum and other pharmaceutically acceptable auxiliary materials. Agent belongs to the field of pharmaceutical preparations. Background technique [0002] Apocynum Jiangya Tablets is an antihypertensive drug recorded in the standard issued by the Ministry of Traditional Chinese Medicine. The standard number is WS3-B-3247-98. Made with chrysanthemum and eight herbs, it has the effects of calming liver and suppressing yang, calming wind and promoting blood circulation, dredging collaterals and relieving pain. . [0003] Traditional oral administration has the disadvantages of fluctuating blood drug concentration, being easily disturbed by factors such as digestive juices and food when absorbed through...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/70A61P9/12A61K35/56
Inventor 关屹闫冬
Owner 北京化药科创医药科技发展有限公司
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