Gastrointestinal contrast agent

Abstract

The invention discloses a gastrointestinal tract contrast agent, which comprises the following composition in parts by weight: in 1000 parts of purified water, any one or several combinations of iodine and iodide containing 0.3-20 parts of pure iodine , wherein iodine and iodide are calculated as pure iodine with a purity of 100%, and 1-8 parts of food-grade liquid paraffin. The advantages are: safe, effective, non-toxic and side effects, the contrast agent can quickly fill the site to be contrasted, and the contrast agent in the filling cavity forms a certain threshold contrast density with adjacent organs and lesions (foci) and is an oral contrast agent for imaging. After drinking this product, the intestinal tract is not easily absorbed and empties quickly; the physical and chemical properties are stable, the contrast is obvious, the image is clear, and the effective diagnosis rate is over 97%, especially for the observation and identification of small lesions (foci) in the middle, lower abdomen and pelvic cavity. It is superior and can improve the sensitivity and specificity of detecting early tumors and lesions of the gastrointestinal tract.

Description

Technical field: [0001] The invention relates to a gastrointestinal tract contrast agent, which is used for clinically carrying out CT and MRI abdominal imaging examinations. Scope of application: abdominal and pelvic CT, oral or enema filling preparation before MRI examination, used for CT and MRI gastrointestinal contrast imaging. Background technique: [0002] Early detection and early treatment of tumors is currently a routine clinical method used in various countries, and imaging diagnosis of the gastrointestinal tract using CT and MRI tomographic imaging technologies is a hot spot in international development and research. If CT and MRI gastrointestinal examinations are performed, the contrast medium in the filling cavity must be resolved first. [0003] At present, the clinical gastrointestinal examination is still based on barium meal and gastric and intestinal endoscopy. Compared with CT and MRI, they are unable to observe the lesions outside the cavity, such as th...

AI Technical Summary

Problems solved by technology

Barium swallow or barium enema can only see the outline of the digestive tract, and the barium-filled gastrointestinal radiography often covers tiny lesions. High-density barium agent and low-density air shadow form air barium contrast radiography, and the inspection process is likely to cause positive results

At the same time, barium radiography cannot complete the observation of extracavitary lesions and the identification of overlapping intestinal flexures. Patients generally report that it is difficult to swallow and vomit when barium sulfate is filled.

[0007] 3. Gas contrast agent (air or CO 2 ): It has been used in clinical research in recent years, but it has not been widely used. The reason is that the gas has obvious susceptibility artifacts, and during the scanning process, the patient needs to hold his breath for 2-5 times. Causes image misregistration at the junction of multiple scans

[0011] At present, there is also a prior patent application, which discloses a contrast agent for CT gastrointestinal tract. In this patent application, a cathartic agent is used for the purpose of emptying the contrast agent in the body as soon as possible and shortening the residence time. However, the contrast agent of the gastrointestinal tract The disadvantage is that it is not suitable for patients with mechanical intestinal obstruction, gastrointestinal bleeding and other diseases