Method for preparing anti-infective agent long-acting injection

Abstract

The invention provides a method for preparing anti-infective agent long-acting injection, and relates to an anti-infective agent long-acting injection. Each 1,000 mL of injection comprises the following components: 10 to 500 g of anti-infective agent, 100 to 900 g of cosolvent, 0 to 100 g of blocker, local anesthetic or stabilizer, and the balance of oil solvent. The method method for preparing the injection comprises: 1, dissolving 10 to 500 g of anti-infective agent in 100 to 900 g of cosolvent and mixing the two well; 2, adding 0 to 100 g of blocker and / or local anesthetic or stabilizer; and 3, adding the oil solvent till full volume and mixing thoroughly to form a uniform system. The method has antibacterial medicaments dissolved in the cosolvent first and then uniformly dispersed in the oil solvent capable of dissolving the antibacterial medicaments mutually so as to prolong the absorption rate of organisms to the medicaments, thereby maintaining the effective concentration of the medicaments in the organisms for a long time, achieving the long-acting effects and reducing the toxic effects of the medicaments.

Description

【Technical field】 [0001] The invention relates to a long-acting injection of an anti-infective agent, in particular to a preparation method and application of a long-acting injection of an anti-infective agent which effectively prolongs the release time of the anti-infective agent and reduces its toxicity. 【Background technique】 [0002] At present, with the continuous improvement of animal husbandry intensification, the possibility of large-scale outbreaks of infectious diseases is also increasing; traditional pharmaceutical preparations are eliminated quickly after administration, and the duration of drug effect is short, but they need to be administered regularly. The workload is heavy, and the curative effect is correspondingly limited. It is known that tylosin (tylosin) injection is mainly used to treat mycoplasma and other infections, such as swine asthma, etc. In practical application, it needs to be injected intramuscularly twice a day for 7 consecutive days. The wor...

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Problems solved by technology

[0008] 3), Chinese patent application (document source - State Intellectual Property Office); patent application number 200810017814.0 applied for a preparation method of tilmicosin long-acting injection, the method first dissolves 10g tilmicosin in 10mL anhydrous in ethanol, and then uniformly dispersed in castor oil; patent 200810017813.6 applied for a preparation method of ivermectin long-acting injection, which is the same as the preparation method of tilmicosin long-acting injection, and the injection prepared by this method Viscosity is big, and administration dosage is inaccurate, finds through the test to use this medicine operation inconvenient, brings great inconvenience to clinical, tilmicosin solubility in dehydrated alcohol is little, and tilmicosin solubility in dehydrated alcohol is 7.8%, difficult to prepare injection.

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