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Ophthalmic solutions

A solution, ophthalmic technology, applied in application, lens cleaning composition, packaging sterilization, etc., can solve the discomfort of lens wearers and other problems

Inactive Publication Date: 2010-06-09
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lenses that are not wet enough at any time will cause significant discomfort to the lens wearer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0173] Preparation of Silicone Hydrogel Lenses

[0174] A monomer mixture was prepared by mixing the ingredients in Table 1 below, where the amounts are parts by weight.

[0175] Table 1

[0176] Element

[0177] The resulting monomer mixture is cast into contact lenses by introducing the monomer mixture into a mold assembly consisting of two polypropylene mold parts, wherein the front mold part has a mold surface for forming the front surface of the contact lens, and the rear The mold part has a mold surface for forming the back surface of the contact lens. The molding part and monomer mixture are then exposed to ultraviolet light to induce free radical polymerization and cure the monomer mixture to form a contact lens. The resulting contact lens was removed from the mold assembly and extracted in a 60°C oven for 1 hour to release the dried lens from the mold.

Embodiment 2

[0179] The lenses of Example 1 were post-treated with a copolymer of NVP and dimethylaminoethyl methacrylate, quaternized with a 20% aqueous solution of diethyl sulfate obtained from Aldrich Chemical Company (Milwaukee, Wisconsin).

[0180] Control lenses (Control Lenses) were prepared by plasma treating the lenses of Example 1 with ammonia gas, followed by extraction with isopropanol for 2 hours, hydration in deionized water, and autoclaving (121°C) in borate buffered saline . By plasma treating the lens of Example 1 with ammonia gas, followed by extraction overnight in a solution made of a mixture of deionized water (70 mL), acrylic acid (13.12 g), NaOH (8.526 g) and isopropanol (350 mL), Hydrate in deionized water containing 30 ppm of NVP and dimethylaminoethyl methacrylate copolymer, quaternize overnight with diethyl sulfate (Aldrich Chemical Company), store in borate buffered saline, and autoclave Sterilization (121° C.) to prepare test lenses according to the invention ...

Embodiment 3

[0199] Preparation of Copolymers of 3-Methacryloylaminopropyl-Dimethyl(3-sulfopropyl)ammonium Hydrochloride (MAPSA) and Glyceryl Methacrylate (GM)

[0200] MAPSA (0.925 g, 3.163 mmol, from Aldrich Chemical Company) was dissolved in 50 ml of deionized water. Into a 250ml three-neck flask equipped with a stir bar and a condenser (connected to an oil bubbler) was added deionized water (150ml), GM (4.963g, 31.02mmol) (via syringe), MAPSA solution and azobisisobutyronitrile (AIBN, 0.050 g). The reaction mixture was sparged vigorously with nitrogen for 20 minutes with stirring, after which the nitrogen flow was reduced. The reaction mixture was heated to 70°C with an oil bath and maintained at this temperature for 48 hours under a continuous nitrogen purge. Store the product in deionized water.

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Abstract

Disclosed are ophthalmic solutions such as packaging solutions for storing ophthalmic devices and lens care solutions for cleaning, disinfecting, rinsing and / or storing ophthalmic devices. The ophthalmic solutions contain at least a polymerization product obtained from a monomeric mixture comprising (a) a monomer bearing a center of permanent positive charge and (b) a non-ionic ethylenically unsaturated monomer, wherein the solution has an osmolality of at least about 200 mOsm / kg, and a pH of about 4 to about 9.

Description

technical field [0001] The present invention relates generally to ophthalmic solutions, such as packaging solutions, and also to multi-purpose solutions. Background technique [0002] Copolymers derived from monomers bearing at least permanently positive centers and ethylenically unsaturated monomers are known. For example, U.S. Patent Nos. 5,648,442, 5,705,583, and 5,783,650 disclose ethylenically unsaturated comonomers (which may be cationic or more preferably zwitterionic) containing groups with permanently positive centers of charge by copolymerization with There are polymers derived from ethylenically unsaturated comonomers capable of binding to ionic groups on surfaces through ionic interactions. These patents further disclose that the polymers may also be copolymerized with diluent monomers, such as N-vinylpyrrolidone (NVP), hydroxyl or polyhydroxy (alkyl)acrylates, eg, sorbitol methacrylate. These patents also disclose that the disclosed polymerization products can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B65B25/00A61L12/08A45C11/00A61K9/00C11D1/62C11D3/37
CPCC11D3/0078A61L12/086B65B55/02B65B25/008
Inventor 赖有进郎卫红
Owner BAUSCH & LOMB INC
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