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Application of diacetyl baicalein in preparing antifebrile

A technology of baicalein and diacetyl, which is applied in the application field of diacetylated baicalein in the pharmaceutical field, and can solve problems such as unsatisfactory antipyretic and analgesic effects

Inactive Publication Date: 2011-09-07
车庆明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Baicalein is also used clinically to treat upper respiratory tract infection, but clinicians report that its antipyretic and analgesic effects are not ideal

Method used

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  • Application of diacetyl baicalein in preparing antifebrile
  • Application of diacetyl baicalein in preparing antifebrile
  • Application of diacetyl baicalein in preparing antifebrile

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Preparation of diacetylated baicalein:

[0062] (a). Preparation of baicalein: 1 kg of baicalin was dissolved in 30 liters of water, 0.3 kg of glucuronidohydrolase was added, stirred at 50°C for 4 days, filtered, and the precipitate was washed with water and dried to obtain baicalein ( 0.6 kg).

[0063] Identification of Baicalein: Mass Spectrometry EI-MS: m / z 270[M] + ; UV spectrum max (MeOH) nm: 277,315; mp.273-275.

[0064] 1H-NMR (dmso-d6): 12.64 (1H, s, 5-OH), 10.55 (1H, 7-OH s), 8.80 (1H, s, 6-OH), 8.04 (2H, d , J=6.0Hz, H-2', 6'), 7.56(3H, m, H-3', 4', 5'), 6.92(1H, s, H-3), 6.61(1H, s, H-8).

[0065] 13C-NMR (dmso-d6): 182.1 (C-4), 162.8 (C-2), 153.6 (C-7), 149.8 (C-9), 147.0 (C-5), 131.7 ( C-4'), 131.0(C-1'), 129.3(C-6), 129.0(C-2', 6'), 126.2(C-3', 5'), 104.4(C-3), 104.2 (C-10), 94.0 (C-8).

[0066] These data are consistent with the baicalein data reported in the literature (isolation and identification of the chemical constituents of Scutellaria baica...

Embodiment 2

[0074] Diacetylated baicalein oral solution:

[0075] Dissolve 5000mg of diacetylated baicalein in 1000ml of water to make a 0.5% aqueous solution, adjust the pH to 6-6.5, heat to dissolve, mix well, put it into a 20ml medicine bottle, seal and sterilize.

[0076] Dosage: Take orally, take diacetylated baicalein 100-300mg daily.

Embodiment 3

[0078] Diacetylated Baicalein Injection:

[0079] Take 2000 mg of diacetylated baicalein, dissolve it in 1000 ml of water to make an aqueous solution, adjust the pH to 6-6.5, heat to dissolve, mix evenly, dispense into 20 mg / 10 ml / bottle injection, and steam for 30 minutes to sterilize.

[0080] Usage and dosage: intramuscular injection or intravenous injection, 50-100mg per day.

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Abstract

The invention discloses a similar medicine which has better effect than baicalein. The invention also provides more pharmacy choices for clinically treating pyrexia caused by the infection of the upper respiratory tract, various fevers and pyrexia. The invention realizes the application of diacetyl baicalein in preparing an antifebrile medicine.

Description

technical field [0001] The invention relates to the medical use of the compound, in particular to the application of diacetylated baicalein in the field of pharmacy. Background technique [0002] Diacetylated baicalein is a derivative of baicalin. Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root, which has antibacterial, diuretic, anti-inflammatory, anti-allergic and antispasmodic effects. Baicalein is also used clinically to treat upper respiratory tract infection, but clinicians report that its antipyretic and analgesic effects are not ideal. Because the Scutellaria baicalensis drugs are safe and reliable, people always hope to obtain more and better Scutellaria baicalensis therapeutic drugs. Contents of the invention [0003] The purpose of the present invention is to provide a similar drug with better effect than baicalein, in order to provide more choices for clinical medication. [0004] The purpose of the present invention is achieved ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P29/00
Inventor 车庆明
Owner 车庆明