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Drug composition of meclofenoxate hydrochloride and polyethylene glycol and preparation method thereof

A technology of meclofenoxate hydrochloride and polyethylene glycol, which is applied in the field of medicine, can solve problems such as instability and easy hydrolysis of meclofenoxate hydrochloride, and achieve the effect of improving stability and safety

Inactive Publication Date: 2010-06-30
HAINAN SIHUAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that meclofenoxate hydrochloride is easily hydrolyzed and extremely unstable in aqueous solution in the prior art, the present invention provides a pharmaceutical composition of meclofenoxate hydrochloride and polyethylene glycol with stable properties and convenient storage and its preparation

Method used

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  • Drug composition of meclofenoxate hydrochloride and polyethylene glycol and preparation method thereof
  • Drug composition of meclofenoxate hydrochloride and polyethylene glycol and preparation method thereof
  • Drug composition of meclofenoxate hydrochloride and polyethylene glycol and preparation method thereof

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Embodiment Construction

[0069] The above-mentioned content of the present invention will be further described in detail through specific implementation in the form of examples below. However, it should not be construed that the scope of the above-mentioned subject matter of the present invention is limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0070] The preparation of the composition aseptic powder injection of embodiment the present invention

[0071] Prescription 1

[0072] Meclofenoxate Hydrochloride 100g

[0073] PEG-2000 0.5g

[0074]

[0075] A total of 1000 bottles were prepared

[0076] Prescription 2

[0077] Meclofenoxate Hydrochloride 100g

[0078] PEG-4000 1g

[0079]

[0080] A total of 1000 bottles were prepared

[0081] Prescription 3

[0082] Meclofenoxate Hydrochloride 250g

[0083] PEG-4000...

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Abstract

The invention belongs to the technical field of medicine, and discloses a drug composition of meclofenoxate hydrochloride and polyethylene glycol and a preparation method thereof. The weight ratio of the meclofenoxate hydrochloride and the polyethylene glycol is 1:0.002-0.1. The invention solves the problems that the meclofenoxate hydrochloride is easily hydrolyzed when meeting water and instably stored in the prior art. The drug composition has stable property and convenient storage, and improves the safety of clinical medication.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition of meclofenac hydrochloride and polyethylene glycol and a preparation method thereof. 2. Background technology [0002] Meclofenoxate Hydrochloride is a central nervous system stimulant that has been used for many years. It was synthesized by the French Academy of Sciences in 1957. Its chemical name is 2-(dimethylamino)ethyl p-chlorophenoxyacetate hydrochloride Salt. It can promote the oxidation-reduction metabolism of brain cells, increase the utilization of carbohydrates, and have an excitatory effect on patients with central nervous system depression. It is used to treat traumatic coma, alcoholism, neonatal hypoxia, and children's enuresis, with definite curative effect and good safety. [0003] Because meclofenoxate hydrochloride is extremely unstable in aqueous solution, the dosage forms for intravenous injection on the market a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/221A61K47/34A61P25/26A61K47/10
Inventor 车冯升郭维城贾中新霍彩霞孟宪慧
Owner HAINAN SIHUAN PHARMA
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