Stable sitafloxacin medicine composition

A sitafloxacin and composition technology, applied in the field of sitafloxacin pharmaceutical composition, can solve the problems of sensitivity, degradation, discoloration and the like, and achieve the effect of mature technology and simple operation

Inactive Publication Date: 2010-06-30
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] New quinolone antibiotics are more sensitive to light due to their chemical structure, and conventional preparation methods are easy to cause degradation and discoloration

Method used

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  • Stable sitafloxacin medicine composition
  • Stable sitafloxacin medicine composition
  • Stable sitafloxacin medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048]

[0049] Preparation method: premix sitafloxacin and sodium sulfite, then weigh microcrystalline cellulose, pregelatinized starch, and low-substituted hydroxypropyl cellulose, mix well, use 50% ethanol aqueous solution to prepare soft material, dry, granulate, Add magnesium stearate, mix well, and compress into tablets.

Embodiment 2

[0051]

[0052] Preparation method: premix sitafloxacin and sodium sulfite, then weigh microcrystalline cellulose, sucrose, and croscarmellose sodium and mix evenly, prepare soft material with 50% ethanol aqueous solution, dry, granulate, and add hard Magnesium fatty acid, mixed evenly, bagged.

Embodiment 3

[0054]

[0055] Preparation method: premix sitafloxacin and sodium thiosulfate, then weigh microcrystalline cellulose, pregelatinized starch, and low-substituted hydroxypropyl cellulose, mix well, prepare soft materials with 50% ethanol aqueous solution, dry, Whole grains, added with magnesium stearate, mixed evenly, and compressed into tablets.

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PUM

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Abstract

The invention relates to a stable sitafloxacin medicine composition, which comprises an effectively treatment amount of novel oral administration carbostyril antibiotic medicine selected from sitafloxacin, medicine stabilizing agents selected from sodium metabisulfite and the like and pharmaceutically acceptable accessory agents. The stable sitafloxacin medicine composition can effectively prevent the degradation of the effective ingredients, and can be used for treating single or mixed bacterial infection of the respiratory tract, the genitourinary tract, the abdominal cavity, the skin soft tissue and the like.

Description

technical field [0001] The invention relates to a stable sitafloxacin pharmaceutical composition. The pharmaceutical composition of the invention can be used for treating single or mixed bacterial infections of the respiratory tract, urogenital tract, abdominal cavity, skin and soft tissues, etc. Background technique [0002] In recent years, the average annual growth rate of the world's antibiotic market is about 8%, and the market share of antibiotics is about 25 billion to 26 billion US dollars. At present, the global anti-infective drug market is facing a key transition from branded drugs to non-patented drugs, which also led to a slight decrease of 1.8% in sales revenue in the market in 2006 compared with 2004, and an increase of about 6.5% in 2007 compared with the previous year. The annual growth rate will be 5% to 6%, and the growth rate will decrease slightly; due to the significant pulling effect of new products, the anti-infective drug market will reach the growt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4709A61K47/02A61P31/04
Inventor 严洁黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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