Medicine composition

A kind of composition and medicine technology, applied in the field of medicine

Active Publication Date: 2010-07-14
HEILONGJIANG ZBD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Effect test

Embodiment 1

[0020] 1. Extraction and purification

[0021] 1) Take 2000g Radix Radix and add water to decoct twice, 1 hour each time, add 8 times the amount of water (weight) for the first time, add 6 times the amount of water (weight) for the second time, combine the decoction, filter and concentrate the filtrate to 200ml , add ethanol to make the alcohol content reach 60%, refrigerate at -4°C for 8 hours, filter, recover ethanol from the filtrate, and obtain the crude nucleoside extract.

[0022] A cationic resin column with a packing height of about 70-80ml is used for separation. First dissolve the crude extract and adjust the pH value to 1.5, put it on the column at a flow rate of 8ml / min, and collect the effluent. It was then eluted with deionized water, and the effluent was collected when the pH value was adjusted to 2.5-3.0. Combine the effluents, add ethanol for precipitation, stand for filtration, and dry to obtain nucleoside compounds.

[0023] 2) Take 250g gardenia and add ...

preparation example 1

[0031] Take 0.2g of the purified geniposide, 0.07g of nucleoside compounds, and 4.5g of amino acids, dissolve them, add them to a 75% ethanol solution containing 2 g of cholic acid and hyodeoxycholic acid (1:1.15), and mix well. Add ethanol to make the alcohol content reach 75%, adjust the pH value to 7.0, refrigerate, filter, recover ethanol from the filtrate, add water, refrigerate, and obtain solution 1. Dissolve 4.5g of baicalin with water for injection, adjust the pH value to 7.5, add a solution containing 0.05g of chlorogenic acid, mix well, combine with solution 1, mix well, add water for injection to 1000ml, and then treat with activated carbon, Refrigerate, potting, and sterilizing to get ready.

preparation example 2

[0033]Take 0.1g of the purified geniposide, 0.05g of nucleoside compounds, and 5.5g of amino acids (the ratio of buffalo horn and mother of pearl in the raw materials is 1:2), after dissolving, add cholic acid, hyodeoxycholic acid 3.5 g (1:1.17) in 75% ethanol solution, mix well, add ethanol to make the alcohol content reach 75%, adjust the pH value to 7.0, refrigerate, filter, recover ethanol from the filtrate, add water, refrigerate to obtain solution 1. Take 5g of baicalin and dissolve it with water for injection, adjust the pH value to 7.5, add a solution containing 0.08g of chlorogenic acid, mix well, combine with solution 1, mix well, add water for injection to 1000ml, and then treat with activated carbon and refrigerate , potting, sterilization, that is.

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Abstract

The invention provides a medicine composition, which is prepared from the following medicine effect raw materials: cholic acid, nacre, hyodesoxycholic acid, gardenia, cornu bubali, radix isatidis, baicalin and honeysuckle. The medicine composition comprises the following medicine effect ingredients in percentage by weight: 1.5 to 4.2 parts of cholic acid type ingredients, 3.5 to 5.5 parts of baicalin, 0.1 to 0.5 part of jasminoidin, 3.5 to 5.5 parts of amino acid, 0.05 to 0.08 part of nucleosides compounds and at most 0.1 part of chlorogenic acid. Experiments show that the medicine composition of the invention has the medicine effect similar to Qingkailing, but the anaphylactic reaction is obviously reduced, and the medicine use safety is improved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition with the functions of clearing heat and detoxification, reducing phlegm and dredging collaterals, refreshing the mind and resuscitating the mind. Background technique [0002] Qingkailing Injection is derived from "Angong Niuhuang Pills" in "Fever Disease Tiaobian" written by Wu Tang in the Qing Dynasty. It is contained in the 2005 edition of "Chinese Pharmacopoeia". Oxycholic acid, gardenia, buffalo horn (powder), isatis root, baicalin and honeysuckle. Cholic acid and hyodeoxycholic acid clear away heat and detoxify, resolve phlegm and resuscitate, cool liver and relieve wind; Yang suppressing, tranquilizing and calming the mind; all medicines work together to clear heat and detoxify, reduce phlegm and dredge collaterals, refresh the mind and open mind. It is clinically used in the treatment of fever, coma, hemiplegia due to apoplexy, confusion;...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P9/10A61P9/02A61P11/00A61P25/00A61K35/56A61K35/32A61K31/575A61K31/7048A61K35/618
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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