34 results about "Hyodesoxycholic acid" patented technology

The invention discloses a Chinese herbal medicine health-care joss stick, comprising a substrate prepared by mixing elm bark powder, cellulosine, a smoke eliminating agent and an additive (additives); the additive (additives) is (are) one or a plurality of an air freshener, a disinfectant, a helminthic epidemic-prevention material and an anti-flu material; the air freshener comprises one or a plurality of peppermint leaf, clove, liquorice and radix isatidis; the disinfectant comprises one or a plurality of ginger, blackberry lily, chrysanthemum flower, wild chrysanthemum flower and lotus leaf; the helminthic epidemic-prevention material comprises one or a plurality of artemisia leaf, radix scutellariae and Chinese thorowax; and the anti-flu material is the mixture of selfheal, mulberry leaf and wild chrysanthemum flower, or the mixture of cholic acid, mother-of-pearl, hyodesoxycholic acid, gardenia, cornu bubali, indigowoad root, radix scutellariae and honeysuckle flower. By adding different kinds of Chinese herbal medicine additives, the Chinese herbal medicine health-care joss stick realizes many beneficial functions, such as air refreshing, disinfection, helminthic epidemic-prevention, flu prevention and the like, thereby being an incensing joss stick.

The invention relates to a quality detection method for a liver protection dropping pill of traditional Chinese medicine preparation. The quality detection method comprises the following steps: measuring the content of effective components of the liver protection dropping pill, including saikoside a and schizandrin, and identifying schisandra chinensis, pulvis fellis suis and artemisia capillaris in the liver protection dropping pill. The quality detection method also comprises the following detection steps: (1) with the saikoside a as a reference substance, measuring whether a radix bupleuri component is contained in a liver protection dropping pill recipe by adopting a high efficiency liquid chromatography method; (2) with the schizandrin as the reference substance, measuring whether a schizandrin component is contained in the liver protection dropping pill by adopting the high efficiency liquid chromatography method; (3) with the schisandrin b as the reference substance, identifying whether a schisandra chinensis component is contained in the liver protection dropping pill by adopting a thin-layer chromatography method; (4) with hyodeoxycholic acid as the reference substance, identifying whether a pulvis fellis suis component is contained in the liver protection dropping pill by adopting the thin-layer chromatography method; and (5) with chlorogenic acid as the reference substance, identifying whether an artemisia capillaris component is contained in the liver protection dropping pill by adopting the thin-layer chromatography method. The quality detection method disclosed by the invention can be used for effectively and reliably controlling the quality of the liver protection dropping pill, and the method is scientific, feasible and reliable.

The invention provides a medicine composition, which is prepared from the following medicine effect raw materials: cholic acid, nacre, hyodesoxycholic acid, gardenia, cornu bubali, radix isatidis, baicalin and honeysuckle. The medicine composition comprises the following medicine effect ingredients in percentage by weight: 1.5 to 4.2 parts of cholic acid type ingredients, 3.5 to 5.5 parts of baicalin, 0.1 to 0.5 part of jasminoidin, 3.5 to 5.5 parts of amino acid, 0.05 to 0.08 part of nucleosides compounds and at most 0.1 part of chlorogenic acid. Experiments show that the medicine composition of the invention has the medicine effect similar to Qingkailing, but the anaphylactic reaction is obviously reduced, and the medicine use safety is improved.

The invention discloses a preparation method of murine deoxycholic acid, which is characterized in that hyodeoxycholic acid (3alpha, 6alpha-dihydroxyl-5beta-cholanic acid) is used as a raw material, and the process comprises the steps of 3, 7-site hydroxyl oxidation, 3-site carbonyl reduction, 7-site carbonyl reduction and purification to obtain high-purity murine deoxycholic acid (3alpha, 6beta-dihydroxyl-5beta-cholanic acid). The murine deoxycholic acid synthesized and prepared through the route is wide in raw material source and sufficient in supply; and the method has the advantages of high yield, high purity and few side reactions, is suitable for large-scale preparation, and can provide data support and standard samples for subsequent related researches.

The invention discloses a quality control method of monkey bezoar and cow-bezoar powder. The quality control standards of the former monkey bezoar and cow-bezoar powder is revised, lamella distinguish method of bilirubin, monkey bezoar, grassleaf sweelflag rhizome, alpinia zerumbet and licorice is added, lamella check method of hyodesoxycholic acid is also added, and further assay method of cinnabar and cholic acid is added. The quality control method of the monkey bezoar and cow-bezoar powder of the invention has a strong specificity, and the quality of the product is more effectively controlled, further the safety and the efficiency of medicines taking by human bodies are guaranteed.

The invention provides a metabolic marker for diagnosing benign and malignant pulmonary nodules and application of the metabolic marker. The metabolic marker is selected from one or combination of 4-hydroxy-L-proline, hyodeoxycholic acid, xanthine, 2-hydroxy-6-aminopurine, 5, 6-dihydrothymine, isobutyryl carnitine, guanine, glutamic acid, asparagine, formononetin, alanine and kynuric acid. The 12 metabolic markers provided by the invention can accurately diagnose and distinguish lung benign and malignant nodules, have high sensitivity and strong specificity, can well replace the existing tissue biopsy and imaging diagnosis mode, reduce trauma and radiation risks, and have clinical use and popularization values.

The present invention discloses one kind of me for treating acute and chronic nasopharyngitis. The medicine is prepared through mixing patchouli oil in 1-30 weight portions and hyodesoxycholic acid in 10-300 weight portions, adding proper amount of supplementary material for orally taken preparation and re-mixing. The medicine of the present invention is used in treating nasopharyngitis and has the outstanding advantages of small dosage, easy taking, high effect and fast acting.

The invention discloses a method for synthesizing lithocholic acid by using hyodeoxycholic acid as a raw material. The present invention uses hyodeoxycholic acid as a starting material, undergoes 7 steps of 24-carboxyl esterification, 3α-hydroxyl and 6α-hydroxyl oxidation to carbonyl, selective reduction, acylation, hydrazone formation, dehydrazone, and hydrolysis to form stones. cholic acid. The starting material of the invention is cheap and easy to obtain, hydrazine hydrate is not used in the synthesis process, the synthesis process conditions are safe, environmentally friendly and mild, the total yield is high, and the method is suitable for industrial production.

The invention belongs to the field of medicine, particularly relates to a preparation method of 6-ethylchenodeoxycholic acid. The method comprises the following steps of using HDCA (hyodesoxycholic acid) as starting raw materials; sequentially performing esterification reaction, oxidation reaction, hydroxy group protection reaction, reaction with ethyl zinc bromide or diethyl zinc reagent, dewatering reaction, oxidation reaction, reduction reaction and hydroxyl removal and carboxyl group protection reaction to obtain the 6-ethylchenodeoxycholic acid. The method provided by the invention has the advantages that the raw material problem can be solved; the severe reaction conditions of strong alkalinity, high temperature and the like can be avoided; the synthesis efficiency of the 6-ethylchenodeoxycholic acid is greatly improved, so that the provided novel preparation method has the advantages that the byproducts are few; the operation is simple and convenient; the reaction conditions are mild; the cost is low; the method is suitable for the large-scale production of the 6-ethylchenodeoxycholic acid.

The invention discloses a crystallizing tank for extracting hyodeoxycholic acid, which comprises a reaction tank and a crystallizing cabin mounted below the reaction tank, a plurality of crystallizing plates are obliquely arranged in the crystallizing cabin, hot gas discharged by the reaction tank is conveyed into the crystallizing plates after being secondarily heated, the reaction tank discharges liquid in a water curtain shape, and the crystallizing cabin is communicated with the crystallizing plates. And the liquid flows along the inclined direction of the crystallization plate and is heated to evaporate and crystallize. According to the crystallizing tank for extracting hyodeoxycholic acid provided by the invention, the crystallizing plate is filled with high-temperature steam, so that high temperature is attached to the surface of the crystallizing plate, liquid in contact with the surface of the crystallizing plate can be evaporated in an extremely short time, hyodeoxycholic acid contained in the liquid can form crystals, and the whole crystals are more convenient to extract; the previous tedious crystallization extraction steps are reduced; and the device recycles and heats steam flowing in the reaction tank, the crystallization cabin and the crystallization plate, so that resources consumed by heat energy provided for heating the crystallization plate are reduced.

The invention discloses a preparation method of 3 alpha-hydroxy-6-keto-5 beta-cholestane-24-acid with low cost and high yield, which is characterized by comprising the following steps: adding hyodeoxycholic acid into a mixed solution of an organic solvent and water, and stirring to dissolve; adding bromide and acid, stirring and dissolving; bromate is added for reaction; adding a terminating agent, and stirring to terminate the reaction; adding water to crystallize the product; and carrying out solid-liquid separation, washing a solid product with water for multiple times, and drying to obtainthe 3 alpha-hydroxy-6-keto-5 beta-cholestane-24-acid. According to the method, a common and safe reagent is adopted, the hyodeoxycholic acid is selectively oxidized into the 3 alpha-hydroxy-6-keto-5beta-cholestane-24-acid under a relatively mild condition, the product purity is greater than 98.0%, and the yield is greater than 85%. The method has the advantages of cheap reagents, simple operation, high process reproducibility, simple post-treatment, high product purity and high yield, and can easily implement industrial production.

The invention provides a method for preparing ursodesoxycholic acid by using hyodeoxycholic acid, which comprises the following steps: firstly, oxidizing 3,6-hydroxyl of hyodeoxycholic acid into 3,6-keto by using a chemical method; secondly, reducing the 3-keto group into 3 alpha-hydroxyl by using 3[alpha]-steroid dehydrogenase, and adding hydroxyl to a substrate by using 7[beta]-hydroxylase to generate 7-hydroxyl; and finally, removing 6-keto by using a chemical method to generate UDCA. The chemical-enzyme method is simple in process, mild in reaction condition, environment-friendly, high in reaction substrate concentration and reproducible in coenzyme, the production cost and the environmental protection pressure are greatly reduced, and the chemical-enzyme method provides an environment-friendly, economical and efficient new thought for preparing the UDCA.

The invention discloses calculus bovis factitius and a preparation method thereof. The calculus bovis factitius comprises the following components in parts by weight: 10-15 parts of taurine, 10-15 parts of cholic acid, 5-10 parts of bilirubin, 15-20 parts of hyodeoxycholic acid, 1-5 parts of cholesterol, 1-5 parts of zinc sulfate, 0.1-3 parts of tricalcium phosphate, 0.1-1 part of ferrous sulfate and 20-50 parts of starch. The prepared calculus bovis factitius is high in the content and purity of effective components, the preparation method is simple, cost is low, and industrial production is easy to achieve.