Medicine composition
A kind of composition and medicine technology, applied in the field of medicine
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Embodiment 1
[0020] 1. Extraction and purification
[0021] 1) Take 2000g Radix Radix and add water to decoct twice, 1 hour each time, add 8 times the amount of water (weight) for the first time, add 6 times the amount of water (weight) for the second time, combine the decoction, filter and concentrate the filtrate to 200ml , add ethanol to make the alcohol content reach 60%, refrigerate at -4°C for 8 hours, filter, recover ethanol from the filtrate, and obtain the crude nucleoside extract.
[0022] A cationic resin column with a packing height of about 70-80ml is used for separation. First dissolve the crude extract and adjust the pH value to 1.5, put it on the column at a flow rate of 8ml / min, and collect the effluent. It was then eluted with deionized water, and the effluent was collected when the pH value was adjusted to 2.5-3.0. Combine the effluents, add ethanol for precipitation, stand for filtration, and dry to obtain nucleoside compounds.
[0023] 2) Take 250g gardenia and add ...
preparation example 1
[0031] Take 0.2g of the purified geniposide, 0.07g of nucleoside compounds, and 4.5g of amino acids, dissolve them, add them to a 75% ethanol solution containing 2 g of cholic acid and hyodeoxycholic acid (1:1.15), and mix well. Add ethanol to make the alcohol content reach 75%, adjust the pH value to 7.0, refrigerate, filter, recover ethanol from the filtrate, add water, refrigerate, and obtain solution 1. Dissolve 4.5g of baicalin with water for injection, adjust the pH value to 7.5, add a solution containing 0.05g of chlorogenic acid, mix well, combine with solution 1, mix well, add water for injection to 1000ml, and then treat with activated carbon, Refrigerate, potting, and sterilizing to get ready.
preparation example 2
[0033]Take 0.1g of the purified geniposide, 0.05g of nucleoside compounds, and 5.5g of amino acids (the ratio of buffalo horn and mother of pearl in the raw materials is 1:2), after dissolving, add cholic acid, hyodeoxycholic acid 3.5 g (1:1.17) in 75% ethanol solution, mix well, add ethanol to make the alcohol content reach 75%, adjust the pH value to 7.0, refrigerate, filter, recover ethanol from the filtrate, add water, refrigerate to obtain solution 1. Take 5g of baicalin and dissolve it with water for injection, adjust the pH value to 7.5, add a solution containing 0.08g of chlorogenic acid, mix well, combine with solution 1, mix well, add water for injection to 1000ml, and then treat with activated carbon and refrigerate , potting, sterilization, that is.
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