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Artificial bezoar and preparation method thereof

A technology for artificial bezoar and taurine, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as lack of pharmacological efficacy, and achieve good product stability, ease of use, and easy operation. Effect

Inactive Publication Date: 2009-09-16
张恒洲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, free bilirubin is insoluble in water and has no pharmacological effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0013] Example 1: Taking the production of 100kg of artificial bezoar as an example, weigh 0.1-30kg of sodium bilirubin, 0.1-35kg of calcium bilirubin, 1-20kg of cholic acid, 1-20kg of taurodeoxycholic acid or hyodeoxycholic acid, Bound cholesterol or free cholesterol 0.1-10kg, combined taurine or free taurine 0.1-10kg, ox gall powder or pig gall powder 1-90kg.

[0014] Mix the above raw materials in a ball mill.

[0015] Start the ball mill and grind for 24 hours to get a very fine powder, which can be sold in powder form. It can also form the same shape and color as natural bezoar according to the mechanism of natural bezoar produced in the gallbladder, and have concentric layers.

[0016] Packaging after passing the inspection.

example 2

[0017] Example 2: Taking the production of 100kg artificial bezoar as an example, weigh bilirubin sodium 0.1-30kg, bilirubin calcium 0.1-35kg, cholic acid 1-20kg, taurodeoxycholic acid or hyodeoxycholic acid 1-20kg, 0.1-10 kg of bound cholesterol or free cholesterol, 0.1-10 kg of a mixture of bound taurine and free taurine, 1-90 kg of beef gall powder or pig gall powder.

[0018] Mix the above raw materials in a ball mill.

[0019] Start the ball mill and grind for 24 hours to get a very fine powder, which can be sold in powder form. It can also form the same shape and color as natural bezoar according to the mechanism of natural bezoar produced in the gallbladder, and have concentric layers.

[0020] Packaging after passing the inspection.

[0021] 2. Purpose

[0022] 1. Used in the production of single or compound drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases.

[0023] 2. Used in the production of single or compound medicines for c...

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PUM

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Abstract

The invention discloses artificial bezoar and a preparation method thereof, and relates to the technical field of production formula and technology of medicine. Sodium bilirubinate, calcium bilirubinate, cholic acid, taurodeoxycholic acid or hyodesoxycholic acid, combined cholesterol or free cholesterol, combined taurine or free taurine or mixture of the combined taurine and the free taurine, ox-bile powder or porcine-bile powder are mixed and grinded into powder. The artificial bezoar contains the sodium bilirubinate, the calcium bilirubinate and other components same as natural bezoar, but does not contain free bilirubin; and the total bilirubin has a constant content of more than 0.1 to 35 percent. The components of each batch of the artificial bezoar are consistent. The artificial bezoar contains no harmful bacteria, virus or ascaris eggs; and the efficacy is higher than the prior artificial bezoar but is equal to the natural bezoar.

Description

technical field [0001] The invention relates to the technical field of production formula and technology of a medicine. Background technique [0002] Natural bezoar is a famous and precious Chinese medicinal material. There are more than 400 kinds of Chinese and Western medicines that require bezoar as a raw material. The demand is very large. Due to the scarcity of natural bezoar, it is far from meeting the demand, and the contradiction between supply and demand is very prominent. Since the 1950s, the first natural bezoar substitute, artificial bezoar, was born. Although it has been modified several times, the composition of artificial bezoar is far from that of natural bezoar. Natural bezoar contains bilirubin sodium and bilirubin elemental calcium, while the artificial bezoar only contains free bilirubin. As we all know, free bilirubin is insoluble in water and has no pharmacological efficacy. Contents of the invention [0003] The purpose of the present invention is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K31/185A61K31/409A61K31/575
Inventor 张恒洲
Owner 张恒洲
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