Pharmaceutical composition for treating cerebral apoplexy and its preparation method

A composition and drug technology, applied in the field of medicine, can solve the problems of many types of diseases, difficulties in process improvement, and unclear material basis of drug effects, etc., and achieve the effect of improving the symptoms of neurological deficits with remarkable effects

Inactive Publication Date: 2007-02-14
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since Qingkailing injection is a compound injection of traditional Chinese medicine, it has a wide range of efficacy and treats many diseases, and the material basis of the efficacy of each medicine is not clear, so it is difficult to improve the process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0039]Experimental example 1 Study on the characteristics of Qingkailing medicinal substances and compatibility in animal models of cerebral ischemia injury

[0040] Focal cerebral ischemia-reperfusion model of middle cerebral artery infarction in rats using suture method, and incomplete cerebral ischemia injury animal model of bilateral common carotid arteries in rats with repeated clipping, and overall evaluation of neurological deficit and mortality , combined with the biochemical analysis of a series of metabolic damage indicators, the screening analysis of the effective components in the active substances of Qingkailing injection was carried out.

[0041] A. Overall effect: including cholic acid, baicalin, gardenia extract, honeysuckle extract, Banlangen extract, mother of pearl and buffalo horn hydrolyzate and other medicinal substances of Qingkailing, all of which can significantly improve the neurological function of model animals Symptoms of dysfunction. There is a s...

experiment example 2

[0048] Experimental Example 2 Application of Cell Model to Screening of Qingkailing Pharmacological Substances

[0049] Using the cultured neurons, glial cells and endothelial cells, the drug effect substance screening of the cell model was carried out under the non-toxic dosage to the normal cultured cells.

[0050] A. Effects on neurons: Qingkailing Quanfang has obvious protective effect on neurons at a certain dose. Among them, the mixture of gardenia, isatis root, mother of pearl and buffalo horn hydrolyzate has obvious protective effect on neurons, promotes the proliferation of neurons (SH-SY5Y), inhibits the apoptosis of neurons, and inhibits lipid peroxides increase the activity of SOD and NOS in the anti-lipid peroxidation system, and increase the concentration of NO; ​​the mixed solution of taurocholic acid, hyocholic acid, gardenia, isatidis, mother of pearl and buffalo horn hydrolyzate can produce neurons It has obvious toxic effect, which inhibits the apoptosis of...

experiment example 3

[0054] Experimental Example 3 Optimal Research on the Compatibility Changes of the Pharmaceutical Composition of the Present Invention

[0055] The pharmaceutical composition of the present invention has four medicines in total, which are set as four influencing factors; each medicine has three orders of magnitude, namely three levels. Therefore, the 4-factor 3-level mixed factor uniform design method was adopted, and the U9 (3×3×3×3) table was used to obtain a total of 10 prescriptions. Rat MCAT cerebral infarction model was used, and Qingkailing injection was used as the control, and six effect indicators, which were closely related to the cerebral ischemic cascade reaction, including iNOS, MDA, TNF-α, IL-1β, vWF and NSE, were tested. Observe the drug effect, comprehensively compare the pharmacological action strength of each formula, and optimize the formula through the total score system based on this value.

[0056] The comprehensive superiority analysis of the group com...

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PUM

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Abstract

The invention discloses a drug combination and its preparing method, made by taurine, hyodesoxycholic acid, baicalin, Gardenia, and mother-of- pearl, firstly preparing gardenia extract and mother-of-pearl powder hydrolyzate, then adding in taurine and hyodesoxycholic acid and regulating the pH value to obtain a mixed drug solution; making alcohol deposition on the mixed drug solution, then adding in fine baicalin powder, and making the processes of regulating pH value, etc, to obtain a total mixed drug solution; taking the total mixed drug solution to prepare into various preparations. The invention improves Gardenia extracting technique, forming a semi-finished product with Gardenia glycoside as the main component. On the premise of keeping the biological effect of qingkai ling curing cerebral embolism disease, it basically eliminates original-existing bad reactions, achieving the purpose of stabilizing effect and detoxicating, able to be used to develop new medicines for curing cerebral embolism and cerebral hemorrhage diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating cerebral apoplexy and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Qingkailing Injection is a traditional Chinese medicine compound injection that is scientifically developed and purified from the classic Chinese medicine prescription Angong Niuhuang Pills. It has the effects of clearing heat and detoxifying, resolving phlegm and dredging collaterals, refreshing the mind and resuscitating the mind. Clinically, it is mainly used for high fever, coma, stroke hemiplegia, acute and chronic hepatitis, upper respiratory tract infection, pneumonia and other diseases. Over the past 22 years of clinical application, due to its obvious curative effect, the application has been increasing day by day. Since 1992, it has been approved as the first-choice essent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61K35/56A61K31/7048A61K31/575A61P9/10A61K131/00A61K35/618
Inventor 王永炎李澎涛潘彦舒徐雅谢利军
Owner BEIJING UNIV OF CHINESE MEDICINE
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