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Application of Qingkailing composition in preparation of medicine for treating and/or preventing radiation damage

A technology of radiation damage and composition, applied in the field of medicine, can solve the problems of high cost, large toxic and side effects, unfavorable preventive medication, etc., and achieve the effects of low toxic and side effects, improved activity, and good development and application prospects.

Active Publication Date: 2020-07-17
SHINEWAY PHARMA GRP LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, cytokine therapy has a good prospect but is expensive; sulfur-containing compounds and hormones have relatively large toxic and side effects, which is not conducive to preventive medication

Method used

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  • Application of Qingkailing composition in preparation of medicine for treating and/or preventing radiation damage
  • Application of Qingkailing composition in preparation of medicine for treating and/or preventing radiation damage
  • Application of Qingkailing composition in preparation of medicine for treating and/or preventing radiation damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Qingkailing composition

[0022]

[0023]

[0024] The above eight flavors, isatidis, gardenia, and honeysuckle are decocted twice with 2000 mL of water, filtered, combined and concentrated into a clear ointment, cooled, added an appropriate amount of ethanol, left to stand, filtered, recovered ethanol and concentrated into a thick ointment for later use. Grind buffalo horn into powder, add to 2mol / L barium hydroxide solution, heat and hydrolyze, and filter the hydrolyzate for later use. Grind mother-of-pearl, add it to 2mol / L sulfuric acid solution, heat and hydrolyze it, filter it while it is hot, remove the precipitated crystals after letting it cool, add the filtrate to the hydrolyzate of buffalo horn under warm conditions, add barium hydroxide to adjust the pH value to 4, put it aside, remove the precipitate, concentrate the filtrate to an appropriate amount, let it cool, adjust the pH value to 7 with 20% sodium hydroxide solution, refrigerate, ...

Embodiment 2

[0025] Embodiment 2: Qingkailing Injection

[0026]

[0027]The above eight flavors, Radix isatidis, add 1000mL water to decoct twice, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to 200mL, add ethanol to make the alcohol content reach 60%, refrigerate, filter, recover ethanol from the filtrate, add water, Refrigerate and set aside. Add water to decoct gardenia twice, the first time for 1 hour, the second time for 0.5 hours, combine the decoction, filter, concentrate the filtrate to 25ml, add ethanol to make the alcohol content reach 60%, refrigerate, filter, and recover ethanol from the filtrate , add water, and refrigerate for later use. Decoct honeysuckle with 1000mL water twice, each time for 0.5 hours, combine the decoction, filter, concentrate the filtrate to 60mL, add ethanol to make the alcohol content reach 75%, filter, adjust the pH value of the filtrate to 8.0, refrigerate, and recover Ethanol, add ethanol to make the alcohol co...

Embodiment 3

[0028] Embodiment 3: Qingkailing tablet

[0029]

[0030] The above eight flavors, isatidis and gardenia are boiled twice with 2000 mL of water, filtered, the filtrates are combined and concentrated into a clear ointment, left to cool, added an appropriate amount of ethanol, left to stand, filtered, recovered ethanol and concentrated into a thick ointment for later use. Honeysuckle is soaked in heated water, filtered, the dregs are decocted with water, filtered, the filtrates are combined and concentrated into a liquid extract, left to cool, added an appropriate amount of ethanol, left to stand, filtered, recovered ethanol, concentrated into a thick paste, and set aside. Grind buffalo horn into powder, add to 2mol / L barium hydroxide solution, heat and hydrolyze, and filter the hydrolyzate for later use. Grind mother-of-pearl, add it to 2mol / L sulfuric acid solution, heat and hydrolyze it, filter it while it is hot, remove the precipitated crystals after letting it cool, add...

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Abstract

The invention relates to the field of medicine, in particular to application of Qingkailing composition in the preparation of drugs for treating and / or preventing radiation injury; the Qingkailing composition, a traditional Chinese medicine composition, is mainly prepared from cholic acid, nacre mother of pearl, hyodeoxycholic acid, cape jasmine fruit, buffalo horn, isatis root, baicalin, and immature flower of Japanese honeysuckle. There are various forms of Qingkailing at present, including injections, oral liquids, capsules, granules, pills and the like; these drugs are clinically applicable to patients with fever, coma, hemiplegia, obnubilation, acute hepatitis, upper respiratory infections, pneumonia, cerebral thrombosis, and cerebral hemorrhage.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Qingkailing composition in the preparation of medicines for treating and / or preventing radiation damage. Background technique [0002] Qingkailing is a pure traditional Chinese medicine compound preparation composed of cholic acid, hyodeoxycholic acid, mother of pearl, buffalo horn, astragaloside, mast, isatis root, and honeysuckle. Patients with persistent high fever, irritability, sore throat, red tongue, yellow fur, and rapid pulse caused by heat poisoning and internal fire poison; upper respiratory infection, viral cold, acute suppurative tonsillitis, acute pharyngitis , acute bronchitis, high fever and other symptoms belong to the above syndromes. Qingkailing is an improved dosage form of Angong Niuhuang Pills. Angong Niuhuang Pills first appeared in Wu Tang's "Went Disease Tiao Bian" in the Qing Dynasty. , syndromes of high fever, irritability, coma,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61P17/18A61K31/575A61K31/7048A61K35/32A61K35/618
CPCA61K31/575A61K31/7048A61K35/32A61K35/618A61K36/195A61K36/315A61K36/355A61K36/744A61K2300/00
Inventor 关秀伟李志刚张纲赵淑欣许桂玲张志伟
Owner SHINEWAY PHARMA GRP LTD
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