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Calculus bovis factitius and preparation method thereof

A technology for artificial bezoar and taurine, which is applied to pharmaceutical formulations, medical preparations containing active ingredients, unknown raw materials, etc., can solve the problems of low content of active ingredients, insufficient purity of raw materials, etc., and achieves simple methods, retained efficacy and cost. low effect

Pending Publication Date: 2021-04-16
四川菲德力制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides an artificial bezoar and a preparation method thereof, which can effectively solve the problems of low content of active ingredients and insufficient purity of raw materials in existing artificial bezoar

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] An artificial bezoar, comprising the following components by weight:

[0033] 10 parts of taurine, 15 parts of cholic acid, 6 parts of calcium bilirubin, 16 parts of hyodeoxycholic acid, 2 parts of cholesterol, 1 part of zinc sulfate, 0.5 parts of tricalcium phosphate, 0.5 parts of ferrous sulfate, and 30 parts of starch .

[0034] Wherein, the preparation process of cholic acid is:

[0035] (1) Add 15% of its weight of sodium hydroxide to ox bile, add water and boil for 20 hours, collect the saponification solution, then adjust its pH value to 3, filter, collect and boil the supernatant for 30 minutes, cool and filter to obtain the crude bile acid ;

[0036] (2) Add 80% ethanol to the crude bile acid, reflux at 50°C for 3h, then add activated carbon with 10% weight of the crude bile acid, continue heating and reflux for 15min, filter, cool in an ice-water bath to 0-5°C, and then use ethanol The crystals were washed to obtain cholic acid with a purity of 96.8%.

[0...

Embodiment 2

[0051] An artificial bezoar, comprising the following components by weight:

[0052] 15 parts of taurine, 10 parts of cholic acid, 5 parts of bilirubin, 20 parts of hyodeoxycholic acid, 5 parts of cholesterol, 2 parts of zinc sulfate, 0.1 part of tricalcium phosphate, 0.1 part of ferrous sulfate, and 50 parts of starch.

[0053] Wherein, the preparation process of cholic acid is:

[0054] (1) Add 10% sodium hydroxide by weight to ox bile, add water and boil for 20 hours, collect the saponified solution, then adjust its pH to 2, filter, collect and boil the supernatant for 20 minutes, cool and filter to obtain the crude bile acid ;

[0055](2) Add 95% ethanol to the crude bile acid, reflux at 90°C for 5h, then add activated carbon with 15% weight of the crude bile acid, continue heating and reflux for 15min, filter, cool in an ice-water bath to 0-5°C, and then use ethanol The crystals were washed to obtain cholic acid with a purity of 98.6%.

[0056] The preparation method o...

Embodiment 3

[0070] An artificial bezoar, comprising the following components by weight:

[0071] 14 parts of taurine, 12 parts of cholic acid, 5 parts of bilirubin, 20 parts of hyodeoxycholic acid, 5 parts of cholesterol, 5 parts of zinc sulfate, 0.5 parts of tricalcium phosphate, 0.8 parts of ferrous sulfate, and 30 parts of starch.

[0072] Wherein, the preparation process of cholic acid is:

[0073] (1) Add 10% sodium hydroxide by weight to ox bile, add water and boil for 24 hours, collect the saponified solution, then adjust its pH to 3, filter, collect and boil the supernatant for 30 minutes, cool and filter to obtain the crude bile acid ;

[0074] (2) Add 90% ethanol to the crude bile acid, reflux at 85°C for 5h, then add activated carbon with 15% weight of the crude bile acid, continue heating and reflux for 30min, filter, cool in an ice-water bath to 0-5°C, and then use ethanol The crystals were washed to obtain cholic acid with a purity of 98.2%.

[0075] The preparation metho...

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PUM

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Abstract

The invention discloses calculus bovis factitius and a preparation method thereof. The calculus bovis factitius comprises the following components in parts by weight: 10-15 parts of taurine, 10-15 parts of cholic acid, 5-10 parts of bilirubin, 15-20 parts of hyodeoxycholic acid, 1-5 parts of cholesterol, 1-5 parts of zinc sulfate, 0.1-3 parts of tricalcium phosphate, 0.1-1 part of ferrous sulfate and 20-50 parts of starch. The prepared calculus bovis factitius is high in the content and purity of effective components, the preparation method is simple, cost is low, and industrial production is easy to achieve.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to an artificial bezoar and a preparation method thereof. Background technique [0002] Natural bezoar is the dried gallstones of bovine animals, which are formed in the bile of cattle for several years. Natural bezoar is a famous and precious Chinese medicinal material, and there are hundreds of kinds of Chinese and Western medicines that need natural bezoar as a raw material. Due to the scarcity of sources of natural bezoar, it is far from being able to meet the needs. Artificial bezoar is usually made from animal bile outside the body of a cow. Since the 1950s, there have been researches on natural bezoar substitutes. In the 1960s, the first artificial bezoar was born. The artificial bezoar is composed of hyocholic acid, deoxycholic acid, free bilirubin, starch and the like. Since the 1970s, many scientific research institutions and scientific and tec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413
Inventor 叶长蓉
Owner 四川菲德力制药有限公司
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