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Traditional Chinese medicine composite for warming and invigorating qi and blood and preparation method and quality control method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition preparation and quality control for warming and nourishing qi and blood, can solve the problems of excellent clinical effect, and achieve the effect of enhancing immunity, high stability and good reproducibility

Active Publication Date: 2012-01-18
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional Chinese medicine composition preparation composed of ten traditional Chinese medicines such as Codonopsis Codonopsis, Atractylodes macrocephala (stir-fried), Poria cocos, roasted licorice, angelica, Chuanxiong, white peony root (wine-fried), rehmannia glutinosa, sun-roasted astragalus, and cinnamon is used as a traditional Chinese medicine for warming qi and blood , very good clinical effect

Method used

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  • Traditional Chinese medicine composite for warming and invigorating qi and blood and preparation method and quality control method thereof
  • Traditional Chinese medicine composite for warming and invigorating qi and blood and preparation method and quality control method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 pill

[0035] Party:

[0036] Codonopsis 80g Atractylodes macrocephala (stir-fried) 80g Poria cocos 80g

[0037] Zhi Licorice 40g Angelica 120g Chuanxiong 40g

[0038] Radix Paeoniae Alba (stir-fried with wine) 80g Rehmannia glutinosa 120g Radix Astragalus 80g

[0039] Cinnamon 20g

[0040] Preparation method: Grind the above ten flavors into fine powder, sieve, and mix well. For every 100g of powder, use 35-50g of refined honey, add appropriate amount of water pills, dry, and make water pills.

[0041] Quality control method:

[0042] TLC identification of Atractylodes Rhizoma Atractylodes Rhizome and Rehmannia glutinosa: Take 18g of the traditional Chinese medicine composition, add 10g of diatomaceous earth, grind well, add 100ml of ethanol, ultrasonicate for 40 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to dissolve the residue, and use it as the test product solution. In addition, take 1g each of Atractylodes macroceph...

Embodiment 2

[0046] Embodiment 2: pharmacodynamic experiment

[0047] The following preparations of the present invention are prepared for Embodiment 1, but this experiment is not a limitation of the present invention, and various dosage forms provided by the present invention can all realize the effects of the present invention.

[0048] 1. The effect on the high temperature resistance experiment of mice

[0049] Test method: Kunming mice were placed in an animal room with room temperature (20±2)°C and relative humidity of 60%, 6 mice / cage, adapted for 3 days, free to eat and drink. Randomly divided into 3 groups, 12 in each group, respectively blank control group, Acanthopanax positive control group, and Chinese medicine composition preparation group of the present invention. Blank control group: intragastric administration of 0.4ml distilled water per day; Acanthopanax positive control group: intragastric administration of Acanthopanax liquid, dose 0.2g·kg -1 d -1 ; Chinese medicine ...

Embodiment 3

[0069] Embodiment 3: the identification method screening test of embodiment 1 pill

[0070] The traditional Chinese medicine composition preparation reduces the cumbersomeness of the test operation of the quality control method, and at the same time more comprehensively guarantees the quality of the medicinal materials. In the present invention, the content of paeoniflorin, the characteristic component of Paeoniflorin in the preparation, is determined by HPLC under the content determination item, and the existence of paeoniflorin is indirectly identified, and the existence of Paeoniflorin in the prescription of the present invention is verified. 1. TLC identification of Radix Astragali The preparation of the test sample is cumbersome, and the medicinal materials of Paeoniae officinalis and Astragalus in the preparation must be purified through solution extraction and macroporous resin column, and the operation is extremely cumbersome. The TLC identification of Rehmannia glutinos...

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Abstract

The invention discloses a traditional Chinese medicine composite for warming and invigorating qi and blood and a preparation method and a quality control method thereof. The composite is made from the raw materials such as Codonopsis, Atractylodes (fried), Poria, Zhi Gan Cao, Chinese angelica root, white peony root (Jiuchao), Rehmannia glutinosa, Sunburn astragalus, cinnamon and the like. The composite has favorable effect on warming and invigorating qi and blood, has strong effect on increasing the immunity of the human body, and has synergetic effect with the antitumor drugs. The treatment control method has good specificity, high stability, good repeatability and high precision, is applicable to the industrialized production, and can really ensure the safety, effectiveness and the reliability of the clinic drugs.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and a quality control method thereof, in particular to a traditional Chinese medicine composition preparation for warming qi and blood and a quality control method thereof. Background technique [0002] Traditional Chinese medicine believes that fatigue is caused by excessive physical and mental overdraft, or unreasonable lifestyle, or bad mental and emotional stimulation, which interferes with the normal activities of the human body. The "Huangdi Neijing" believes that "fatigue" means "tired, less physical and qi", "blood and qi are exhausted, which makes people feel relieved", and it is manifested in symptoms such as "tiredness, body weight, weight, and limbs". Diarrhea is mostly due to insufficient qi and blood, and weak viscera function. [0003] The traditional Chinese medicine composition preparation composed of ten traditional Chinese medicines such as Cod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P1/14A61P39/00G01N30/90G01N30/02
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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