Method for preparing diphenyl acetylene class compound in eutectic ionic liquid

Abstract

The invention discloses a method for preparing a diphenyl acetylene class compound in eutectic ionic liquid, which comprises the following steps of: adding quaternary ammonium salt-imidazole eutectic ionic liquid into a reactor under protective gas, taking aryl iodide and aromatic acetylene as raw materials and CuI / Pd(Ph3P)4 / Ph3P as a catalyst and reacting for 4 to 12h under the temperature condition of 20 to 60 DEG C to prepare the diphenyl acetylene class compound. The invention takes the quaternary ammonium salt-imidazole eutectic ionic liquid as a solvent to prepare the diphenyl acetyleneclass compound and has the advantages of low reaction temperature, small contamination in the preparation process, simple operation, energy saving, discharge reduction and environmental protection, the product has simple and convenient separation and high yield, and the catalyst can be recycled.

Description

technical field The invention relates to a green synthesis and preparation method of tolan compounds, in particular to a method for preparing tolan compounds in a deep eutectic ionic liquid. Background technique Diphenylacetylene compounds are an important class of liquid crystal intermediates, usually prepared by Sonogashira reaction, but in Sonogashira reaction, a higher reaction temperature is required, and the reaction solvent is toluene, THF, MeCN, DMF, dioxane, etc. Organic molecular solvents. With the continuous development of modern organic synthesis methodology, people pay more and more attention to the greening of the reaction process, and there are further requirements for the synthesis technology of the reaction and green solvents, so the original preparation method is more and more unsuitable for people's needs. new demand. On the other hand, since 2003, the research groups of Andrew, Tsuda and Hou have respectively reported the eutectic system ChCl-urea (Che...

AI Technical Summary

Problems solved by technology

However, so far, there is no research and report on the preparation of tolanyl compounds by using deep eutectic ionic liquids, so as to make up for the shortcomings of the traditional preparation methods of tolanyl acetylenes.

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