Application of astragalus mongholicus polysaccharide as medicine prepared for treating neurodegenerative diseases

A neurodegenerative, astragalus polysaccharide technology, used in nervous system diseases, drug combinations, pharmaceutical formulations, etc.

Inactive Publication Date: 2010-09-15
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether astragalus polysaccharide can effectively inhibit the aggregation of polyglutamine and alleviate the toxicity of polyglutamine aggregation has not been reported yet.

Method used

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  • Application of astragalus mongholicus polysaccharide as medicine prepared for treating neurodegenerative diseases
  • Application of astragalus mongholicus polysaccharide as medicine prepared for treating neurodegenerative diseases
  • Application of astragalus mongholicus polysaccharide as medicine prepared for treating neurodegenerative diseases

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Experimental program
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Effect test

Embodiment Construction

[0011] Combined with the following specific embodiments, astragalus polysaccharide inhibits abnormal aggregation of polyglutamine in mammalian cells, astragalus polysaccharide inhibits abnormal aggregation of polyglutamine in Caenorhabditis elegans, and astragalus polysaccharide relieves abnormal polyglutamine in Caenorhabditis Aggregation-induced neurotoxicity and the effect of astragalus polysaccharides on the lifespan of Caenorhabditis elegans are further explained:

[0012] One, the preparation of astragalus polysaccharide

[0013] 1. Astragalus medicinal material (purchased from Beijing Tongrentang Wuhan store) is crushed and passed through a 0.85mm sieve;

[0014] 2. Weigh 100g of astragalus powder;

[0015] 3. 500ml of petroleum ether, 70°C, reflux extraction for 1 hour, twice, evaporate the medicinal materials after suction filtration;

[0016] 4. 500ml 95% ethanol, 80°C, reflux extraction for 2 hours, twice, evaporate the medicinal materials after suction filtration...

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Abstract

The invention discloses an application of astragalus mongholicus polysaccharide as the medicine prepared for treating neurodegenerative diseases.Proven by the mammal cell and caenorhadits elegans disease model test, the astragalus polysaccharides has the following functions: effectively inhibiting abnormal aggregation of mammal cell and caenorhadits elegans disease model polyglutamine, effectively relieving neurotoxicity triggered by the abnormal aggregation of polyglutamine and noticeably lengthening life span of the caenorhadits elegans model. With the functions of the astragalus polysaccharides, minor ingredients can be added to the astragalus polysaccharides according to pharmaceutical principles to serve as the medicine for treating neurodegenerative diseases or to be prepared into various dosage forms such as capsule, tablet or granule and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmacy. It particularly relates to an application of astragalus polysaccharide in preparing medicine. technical background [0002] Neurodegenerative diseases refer to progressive diseases, including Huntington's disease, Alzheimer's disease and Parkinson's disease, which are characterized by the gradual decline and even death of specific nerve cells and tissues. Although there is no drug that can effectively treat neurodegenerative diseases, with the in-depth research on such diseases, some small molecular compounds with potential therapeutic effects have gradually been discovered. These compounds mainly prevent cell decline, change downstream pathological effects and reduce the damage caused by reducing the level of abnormal protein aggregation or interfering with its formation process, so as to improve the symptoms of the disease. Among them, natural small molecule compounds derived from plants suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P25/28A61P25/14A61P25/16
Inventor 黄泽波张晗蕊潘妮刘永梅邹盛珑李海峰
Owner WUHAN UNIV
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