Osmanthus glabra extract and its uses

A technology of extract and cinnamon, applied in the field of medicine, can solve problems such as difficult to control intestinal symptoms

Inactive Publication Date: 2012-02-01
FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the best-selling pancrelipase inhibitor in the market is Xenical, which has the characteristics of strong activity and good stability, but at the same time has the disadvantages of difficult-to-control intestinal symptoms, greasy stools, vomiting and abdominal distention.

Method used

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  • Osmanthus glabra extract and its uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation of embodiment 1 laurel laurel extract

[0013] After 20 kg of dry stems and branches of Osmanthus glabrata were crushed, soaked in 100 liters of 95% ethanol for 12 hours, then percolated, collected 400 liters of percolation liquid, concentrated and dried to obtain 1.5 kg of extract. The extract was dissolved in water and extracted with chloroform, and the recovered solvent was concentrated to dryness to obtain 50 grams of the extract of the present invention. According to high-performance liquid chromatography analysis, the sum of the contents of isopentenyl-substituted flavones and arylbenzofuran compounds in the extract is 60%.

Embodiment 2

[0014] The preparation of embodiment 2 laurel laurel extract

[0015] After 20 kg of dry stems and branches of Osmanthus glabrata were crushed, soaked in 100 liters of 70% ethanol for 12 hours, then percolated, collected 400 liters of percolation liquid, concentrated and dried to obtain 1.2 kg of extract. The extract was dissolved in water and extracted with chloroform, and the recovered solvent was concentrated to dryness to obtain 40 grams of the extract of the present invention. According to high performance liquid chromatography analysis, the sum of the contents of isopentenyl substituted flavones and aryl benzofuran compounds in the extract is 52%.

Embodiment 3

[0016] The preparation of embodiment 3 laurel laurel extract

[0017] After 20 kg of dry stems and branches of Osmanthus glabrata were pulverized, they were soaked three times in 100 liters, 80 liters, and 60 liters of 80% aqueous methanol at room temperature, and the extracts were combined, concentrated and dried to obtain 1.0 kg of extract. The extract was dissolved in water and extracted with chloroform, and the recovered solvent was concentrated to dryness to obtain 32 grams of the extract of the present invention. Through high-performance liquid chromatography analysis, the sum of the contents of isopentenyl-substituted flavones and arylbenzofuran compounds in the extract is 40%.

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Abstract

The invention belongs to the technical field of medicine, and relates to an extract of laurel laurel and its application. The present invention uses the stems and branches of Osmanthus glabrata as raw material, extracts with alcohols or / and water to obtain the total extract, then dissolves the total extract in water, extracts with petroleum ether, chloroform or dichloromethane solvent respectively, and takes chloroform Or the extract phase of dichloromethane, recover the solvent and dry to obtain the extract. The content of isopentenyl substituted flavonoids and aryl benzofuran compounds in the extract is 30%-60%. The results of in vitro pancreatic lipase activity test and animal in vivo experiments show that the extract of the present invention has obvious pancreatic lipase inhibitory activity and weight loss effect, and can be used to prepare drugs for preventing or treating common clinical obesity and related metabolic diseases .

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an extract of laurel laurel and its use in preparing medicines for preventing or treating obesity and related metabolic diseases. Background technique [0002] In the past 20 years, the incidence of obesity has been increasing all over the world, especially in developed countries. Due to the rapid development of the economy and the continuous improvement of living standards, the problems of insufficient exercise and relative excess energy intake have always existed in the lifestyle of modern people, which has led to the energy intake of many modern people exceeding energy consumption, and the excess energy will be Part of it is stored as fat in adipose tissue, and its accumulation can lead to obesity and related diseases, such as diabetes, cancer, heart disease, hyperlipidemia, and fatty liver. [0003] Currently, the treatment of obesity consists mainly in the development of dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/60A61P3/04A61K135/00
Inventor 侯爱君王贺瑶黄建明赵婷闫桂蕊
Owner FUDAN UNIV
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