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Novel secoiridoid compound and application in preparation of anti-inflammatory drug

A technology for compounds and uses, applied in the field of use in the preparation of anti-inflammatory drugs, can solve problems such as no compounds yet

Inactive Publication Date: 2012-04-25
BEIJING FATAI TIMES PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report similar to the chemical structure of the compounds of the present invention and derivatives thereof

Method used

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  • Novel secoiridoid compound and application in preparation of anti-inflammatory drug
  • Novel secoiridoid compound and application in preparation of anti-inflammatory drug
  • Novel secoiridoid compound and application in preparation of anti-inflammatory drug

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The dried roots of Gentiana Straminea Maxim. (Gentiana Straminea Maxim.) of the genus Gentian were selected and extracted with 8 times the volume of 70% ethanol for 2 times, the first time was 2 hours, the second time was 1.5 hours, and then filtered; Concentrate under reduced pressure to an extract with a density of about 1.3; dissolve the extract in water, and extract with petroleum ether (boiling point 60-90℃), chloroform, ethyl acetate and n-butanol; combine the extracts of different polarities and reduce pressure After concentration, it is dried in a vacuum drying oven at 50-70°C to obtain 230 g of dry n-butanol extract. The dried n-butanol extract was subjected to silica gel chromatography, namely chromatographic separation I, chloroform-methanol 50:1→30:1→20:1→10:1→5:1→2:1 mixed eluent gradient wash Decompose, collect in portions, each 100ml, vacuum concentration, collect a total of 873 fractions, combine the same fractions after silica gel thin layer chromatograp...

Embodiment 2

[0024] The dried roots of Gentiana Straminea Maxim. (Gentiana Straminea Maxim.) of the genus Gentian were selected and extracted with 8 times the volume of 70% ethanol for 2 times, the first time was 2 hours, the second time was 1.5 hours, and then filtered; Concentrate under reduced pressure to an extract with a density of about 1.3; dissolve the extract in water, and extract with petroleum ether (boiling point 60-90℃), chloroform, ethyl acetate and n-butanol; combine the extracts with different polarities and reduce pressure After concentration, it is dried in a vacuum drying oven at 50-70°C to obtain 230 g of dry n-butanol extract. The dried n-butanol extract was subjected to silica gel chromatography, namely chromatographic separation I, chloroform-methanol 50:1→30:1→20:1→10:1→5:1→2:1 mixed eluent gradient wash Detach, collect in portions, each 100ml, vacuum concentration, collect a total of 873 fractions, combine the same fractions after silica gel thin layer chromatograph...

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Abstract

The invention relates to a novel secoiridoid compound and application in the preparation of anti-inflammatory drugs. A novel compound is extracted and separated from gentiana straminea, has a chemical structural general formula shown in a formula I and has anti-inflammatory activity. The invention also relates to a use of the compound or pharmaceutically acceptable salts of the compound in the preparation of drugs, in particular to a use in the preparation of anti-inflammatory drugs. The invention also relates to a pharmaceutical composition taking the compound as a main component.

Description

Technical field [0001] The invention relates to a new cleavage iridoid compound and its derivatives extracted and separated from Gentiana straminea Maxim. The present invention also relates to the use of the compound or its pharmaceutically acceptable salts in the preparation of medicines, especially the use in the preparation of anti-inflammatory drugs. The present invention also relates to a pharmaceutical composition with the compound or its pharmaceutically acceptable salt as the main component. Specifically, the present invention relates to compounds of formula I: [0002] Background technique [0003] Gentiana is an important traditional Chinese medicine in my country. It was first published in the "Shen Nong's Materia Medica" and was listed as a medium grade. "Gentiana is responsible for cold and heat evil, cold dampness, arthralgia, joint pain, drainage, and urination". Clinical treatment is used for rheumatic arthralgia, tendons and veins constriction, joint pain, hot ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61P29/00
Inventor 陈光
Owner BEIJING FATAI TIMES PHARMA TECH
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