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Microemulsion composition and preparation method thereof

A technology of composition and microemulsion, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, toiletry preparations, etc., can solve the problems of micro-toxicity, and achieve the effects of small impact, transdermal penetration, and uniform dispersion

Inactive Publication Date: 2010-11-24
上海媚兰生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these emulsifiers can effectively emulsify oily substances, solubilize the active ingredients, enhance the efficacy, stability and antisepsis of the preparations, there is a problem of slight toxicity when used, and it needs to be clear that these emulsifiers are also added to cosmetics. The substance, no matter in terms of manufacturing cost or physical health, is not what people expect

Method used

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  • Microemulsion composition and preparation method thereof
  • Microemulsion composition and preparation method thereof
  • Microemulsion composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh raw materials according to the table:

[0041]

[0042] Step 1, heat component A to 75°C and stir evenly; at the same time, heat component B to 75°C;

[0043] Step 2, under stirring, slowly drop component B into component A, and stop heating when obvious blue light is observed;

[0044] Step 3, cooling the solution in step 2 until the temperature drops to 35° C., adding component C and stirring evenly to obtain a microemulsion composition.

Embodiment 2

[0046] Weigh raw materials according to the table:

[0047]

[0048] Step 1, heat component A to 85°C and stir evenly; at the same time, heat component B to 85°C;

[0049] Step 2, under stirring, slowly drop component B into component A, and stop heating when obvious blue light is observed;

[0050] Step 3, cooling the solution in step 2 until the temperature drops to 40°C, adding component C, stirring evenly to obtain a microemulsion composition;

[0051] Step 4, further cooling the solution in step 3 to room temperature, adding component D, and stirring evenly to obtain a microemulsion composition.

Embodiment 3

[0053] Weigh raw materials according to the table:

[0054]

[0055] Step 1, heat component A to 80°C and stir evenly; at the same time, heat component B to 80°C;

[0056] Step 2, under stirring, slowly drop component B into component A, and stop heating when obvious blue light is observed;

[0057] Step 3, cooling the solution in step 2 until the temperature drops to 45°C, adding component C, stirring evenly to obtain a microemulsion composition;

[0058] Step 4, further cooling the solution in step 3 to room temperature, adding component D, and stirring evenly to obtain a microemulsion composition.

[0059]The present invention adopts non-ionic emulsifier, selects suitable oil, and the microemulsion composition droplet that forms is far smaller than emulsion liquid droplet, disperses more evenly, and the impact on external environment is little, more stable, therefore, can be used as solvent, has It is conducive to transdermal penetration and promotes the exertion of fu...

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Abstract

The invention relates to a microemulsion composition and a preparation method thereof. The microemulsion composition comprises the following components in percentage by weight: 10 to 20 percent of component A, 15 to 30 percent of component B and 50 to 70 percent of component C, wherein the component A comprises the following components in part by weight: 1.5 to 3 parts of non-ionic emulsifier, 0.5 to 1.5 parts of cetyl alcohol ether-6, 1.0 to 2.5 parts of stearyl ether-21, 5 to 10 parts of liquid paraffin and 2 to 8 parts of octyl palmitate or butyrospermum parkii; the non-ionic emulsifier is lecithin, polyglyceryl fatty acid ester or a mixture thereof; the component B is deionized water; and the component C comprises glycerol and deionized water in a weight ratio of 1:3-7. The microemulsion composition provided by the invention has the liquid drops much smaller than those of an emulsion, is stable and favorable for skin penetration, promotes the exertion of effective substances, and can be widely applied to the cosmetics industry.

Description

technical field [0001] The invention relates to a microemulsion composition and a preparation method thereof, and the microemulsion composition is suitable for the cosmetic industry. Background technique [0002] The active ingredients of cosmetics determine its efficacy, but any cosmetic must be carried through a suitable carrier to exert its due effect. That is to say, the composition and properties of the cosmetic matrix directly affect the release, penetration and absorption of its active ingredients. Therefore, even with the same formula, the effects produced by different solvents are quite different. [0003] Human skin mainly absorbs external substances through three ways: 1. Enter through hair follicles, sebaceous gland pores and sweat pores; 2. Enter directly through the keratinocyte membrane; 3. Enter through the gap between keratinocytes. Generally, the droplet of cosmetic emulsion is between 1-10 microns, and the active ingredients of the product cannot penetra...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/06A61Q19/00
Inventor 吕霞姚绍冈杨立峰
Owner 上海媚兰生物科技发展有限公司
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