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Earthworm crystal powder, preparation process and application thereof

A technology of dragon crystal and crystal powder, applied in dragon crystal powder and its preparation process and application field, can solve the problems of affecting relaxation, compression, reducing the elasticity of blood vessels, and being difficult to recover, so as to promote blood flow, inhibit thrombosis, and delay aging. Effect

Inactive Publication Date: 2011-11-23
龚之森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The blood viscosity circulating in human blood vessels is the result of the balance between platelet-based coagulation factors and ATP anticoagulant factors secreted by vascular endothelial cells. Generally, the normal blood viscosity of healthy people around 30 years old is about 2.5, but with age The damage of vascular endothelial cells is not easy to recover, the ATP in the blood is less and less, and the excess fat, collagen and fibrin in the blood gradually coagulate into atheroma and adhere to the blood vessel wall, reducing the elasticity of blood vessels, affecting relaxation and compression, and causing high blood pressure

Method used

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  • Earthworm crystal powder, preparation process and application thereof
  • Earthworm crystal powder, preparation process and application thereof
  • Earthworm crystal powder, preparation process and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1. dragon crystal powder (taking the production of 10 kilograms of dragon crystal powder as example)

[0035] Take about 500 kilograms of fresh and live earthworms, rinse them and freeze them into several ice cubes in a freezer at -20°C, so that the living cells of earthworms can be frozen and broken. After the earthworm ice cubes are taken out, they are dissolved in physiological saline at 37° C., and can be completely dissolved in about 1 hour. (The lower the dissolution temperature, the longer the time required), because the living cells of earthworms have been frozen and broken, the active substances in the cells after dissolution are easy to release, and the homogenate of earthworms is obtained. The function of physiological saline is to protect the active substances of earthworms from being destroyed. The earthworm homogenate is pre-centrifuged at a speed of 1100rpm with a centrifuge, and the excrement in the earthworm body is remove...

Embodiment 2

[0036] Example 2. Effect of Longjing Powder on Thrombosis in Rats in Vitro

[0037] Improved with reference to Chandler method [1] , self-designed device cast-1 simulates thrombus instrument. The siliconized polyethylene tube has a diameter of 5 mm, a length of 245 mm, and a circular shape. The radius of rotation is 47mm, the included angle with the horizontal plane is 75°, the pendulum swings, and the blood flow speed in the ring is 61.57mm / s. During the experiment, the temperature of the instrument and the tube was 38±0.1°C. The rotation observation time is 8 minutes. From 42 Wistar rats, 1ml of blood was collected with disposable plastic syringes and silicon-coated needles. Dragon crystal powder was dissolved in distilled water to prepare a 22.4mg / ml aqueous solution, and the dosage was 0.2ml / 100gB.W for oral administration, and blood was collected 1 hour after oral administration. Before the DIC rat experiment, the rat brain powder extract was injected through the dor...

Embodiment 3

[0045] Example 3. In vitro dissolution of dragon crystal powder on whole blood clots and fibrin clots

[0046] Take 1ml of whole blood from normal rats, and add 0.5ml of dragon crystal powder solution (22.4mg / ml) to the coagulated whole blood after 15 minutes. After standing at 4°C for 24 hours, it was weighed. Receive 0.5ml plasma plus 0.5ml CaCl 2 , after forming a white fibrin clot, add 0.5ml dragon crystal powder solution, place it for 24 hours and weigh it. The control group was replaced by the same volume of normal saline. The results are shown in Table 3.

[0047] Table 3 Effect of Dragon Crystal Powder on whole blood clot and fibrin clot (after 24h in vitro)

[0048]

[0049] * P<0.01

[0050] The above experimental results show that Longjing Powder can directly dissolve thrombus without relying on AT-III.

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Abstract

The present invention belongs to the field of traditional Chinese medicine and relates to earthworm crystal powder, a preparation process and application thereof. The earthworm crystal powder in particular refers to a natural active protein mixture prepared from fresh and live Chiziaisheng earthworms by extracting, separating, concentrating and drying according to the preparation method. The preparation process comprises the following steps of: washing fresh and live Chiziaisheng earthworms clean and then freezing into ice cakes; then putting the ice cakes into aqueous solution of salt to autolyze, and stirring autolysate into a size; centrifuging the obtained uniform size at least once; carrying out pre-filtering, sterilization and continuous hyperconcentration twice; and finally drying the supernatant into powder. The earthworm crystal powder has dual functions of resisting coagulation and activating fibrinolysis so as to suppress the formation of thrombi and promote the dissolution of the thrombi and can be used for preparing medicaments for improving the microcirculation and dissolving the thrombi.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a dragon crystal powder and its preparation process and application. Background technique [0002] The five viscera and six lungs of the human body are composed of various functional cells. They need blood to provide nutrients and oxygen for their survival and maintenance of normal physiological state. Freshly oxygenated blood runs smoothly throughout the body. [0003] To keep blood flowing throughout the body, a normal and balanced blood viscosity must be maintained. The blood viscosity circulating in human blood vessels is the result of the balance between platelet-based coagulation factors and ATP anticoagulant factors secreted by vascular endothelial cells. Generally, the normal blood viscosity of healthy people around 30 years old is about 2.5, but with age The damage of vascular endothelial cells is not easy to recover, the ATP in the blood is less and less, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P7/02A61K35/62
Inventor 龚之森
Owner 龚之森