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Prophylactic or therapeutic agent for ocular disease accompanied by optic nerve disorder

A technology for optic nerve injury and eye diseases, applied in sensory diseases, organic chemistry, pill delivery, etc., can solve the reports that there is no pharmacological effect of ebselen, and there is no pharmacological effect implying the prevention or treatment of ebselen, etc. question

Inactive Publication Date: 2011-01-26
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] As mentioned above, there are no reports investigating the pharmacological effects of ebselen on RGCs
In addition, the above prior art literature does not imply that ebselen can treat glaucoma, glaucomatous optic neuropathy, glaucomatous visual field narrowing, glaucomatous optic atrophy, retinal vascular occlusion, retinitis pigmentosa, Leber's disease, etc. Pharmacological effects in the prevention or treatment of eye diseases

Method used

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  • Prophylactic or therapeutic agent for ocular disease accompanied by optic nerve disorder
  • Prophylactic or therapeutic agent for ocular disease accompanied by optic nerve disorder
  • Prophylactic or therapeutic agent for ocular disease accompanied by optic nerve disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0047] Test 1. Study on the gene expression induction ability of the second-stage enzymes and antioxidant enzymes of the foreign body metabolism system using the retinal nerve culture system derived from fetal mice

[0048] Using a retinal nerve culture system derived from fetal mice (Brain Res. 2003; 967: 257-66), the gene expression inducibility of ebselen's foreign body metabolism system stage 2 enzymes and antioxidant enzymes was evaluated. It should be noted that the retinal nerve culture system derived from fetal mice is widely used as a technique for culturing retinal nerve cells, and is often used as one of the tools for studying optic nerve diseases such as glaucoma.

[0049] (Evaluation method)

[0050] Retinal neurons from fetal mice [Slc: Wistar / ST, 18 days old] were isolated, seeded on polyethyleneimine-coated plastic coverslips, and incubated in Eagle's basal medium containing 10% fetal bovine serum. After culturing in medium for 3 days, a solvent (0.1% ethanol)...

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Abstract

Disclosed is a novel use application of 2-phenyl-1,2-benzisoselenazol-3(2H)-one or a salt thereof for medical purposes. 2-Phenyl-1,2-benzisoselenazol-3(2H)-one or a salt thereof has an excellent inhibitory effect on the cell death of retinal ganglion cells in a pharmacological test using rats, and is therefore useful as a prophylactic or therapeutic agent for an ocular disease accompanied by an optic nerve disorder.

Description

technical field [0001] The present invention relates to a preventive or therapeutic agent for ocular diseases accompanied by optic nerve damage, using 2-phenyl-1,2-benzisoselenazol-3(2H)-one or a salt thereof as an active ingredient. Background technique [0002] The retina has the function of receiving external light and plays an important role in visual function. Structurally, starting from the retinal pigment epithelium layer, it is composed of 10 layers including the inner plexiform layer, the ganglion cell layer, and the nerve fiber layer, and is a tissue with a thickness of 0.1 to 0.5 mm. In the inner plexiform layer, there are nerve cells called amacrine cells that pair with ganglion cell processes to form synapses, and since they respond well at the beginning and end of light exposure, it is considered that these nerve cells are Functions as a detector of light intensity. In the ganglion cell layer, there are ganglion cells located in the innermost part of the reti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/41A61K9/06A61K9/08A61K9/20A61P27/02A61P27/06C07D293/06
CPCA61K9/0019A61K9/2054A61K9/2018A61K9/2059C07D293/10A61K9/0048A61P27/02A61P27/06
Inventor 平井慎一郎笹冈正显清家寿之
Owner SANTEN PHARMA CO LTD
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