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Quality detecting method for polygonum perfoliatum

A quality inspection method and technology of bar return, which can be used in pharmaceutical formulations, material separation, analysis of materials, etc., can solve problems such as lack of bactericidal and antiviral effects, and achieve the effect of saving time, high accuracy and sensitivity, and improving efficiency.

Active Publication Date: 2011-04-27
贵州远程制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And the existing quality inspection method of the medicinal material and preparation thereof mainly adopts high performance liquid chromatography to measure the content of quercetin, thus it can be seen that the determination of the content of quercetin is very important for a method for measuring the quality of the medicinal material. There is a big deficiency, because quercetin is not an organic acid, nor does it have a strong bactericidal and antiviral effect

Method used

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  • Quality detecting method for polygonum perfoliatum
  • Quality detecting method for polygonum perfoliatum
  • Quality detecting method for polygonum perfoliatum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The quality detection method of the barbarian medicinal materials includes the following steps:

[0023] (1) Preparation of the test solution: Take an appropriate amount of medicinal material, crush it, pass through a No. 3 sieve, weigh 2 g, weigh it accurately, put it in a 100 mL conical flask with a stopper, add 50 mL of methanol, leave it for 3 hours, and ultrasonically treat it for 1 hour , shake well, filter, wash the residue with methanol until colorless, evaporate to dryness, and use 0.5moL·L -1 Dissolve 30mL of sodium hydroxide solution in 3 times, transfer to the conical flask, reflux in a water bath at 50-60°C for 2 hours, let it cool, transfer it into a separatory funnel, wash the conical flask with 5mL of water, and put the washing liquid into the separatory funnel , adjust the pH to 2 with hydrochloric acid, extract 4 times with diethyl ether, 20 mL each time, combine the diethyl ether solutions, evaporate to dryness in a water bath at 50-60 ° C, dissolve w...

Embodiment 2

[0048] The quality detection method of the barbarian medicinal materials includes the following steps:

[0049](1) Preparation of the test solution: Take an appropriate amount of medicinal material, crush it, pass through a No. 3 sieve, weigh 2 g, weigh it accurately, put it in a 100 mL conical flask with a stopper, add 50 mL of methanol, leave it for 3 hours, and ultrasonically treat it for 1 hour , shake well, filter, wash the residue with methanol until colorless, evaporate to dryness, and use 0.5moL·L -1 Dissolve 30mL of sodium hydroxide solution in 3 times, transfer to the conical flask, reflux in a water bath at 50-60°C for 2 hours, let it cool, transfer it into a separatory funnel, wash the conical flask with 5mL of water, and put the washing liquid into the separatory funnel , adjust the pH to 2 with hydrochloric acid, extract 4 times with diethyl ether, 20 mL each time, combine the diethyl ether solutions, evaporate to dryness in a water bath at 50-60 ° C, dissolve wi...

Embodiment 3～12

[0073] Embodiment 3~12: method is the same as embodiment 1

[0074] Embodiment 3~12 ten batches of test product measurement results are shown in the following table:

[0075]

[0076]

[0077] According to the content measurement results of 12 batches of samples in the above Examples 1-12, and considering the difference in the place of origin, picking period and texture of the medicinal materials, it is determined that the ferulic acid content of this medicinal material must not be less than 0.06% (calculated as dry goods), and the vanillic acid content Not less than 0.015% (calculated as dry goods).

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Abstract

The invention discloses a quality detecting method for polygonum perfoliatum, comprising the following steps of: preparing a test solution; preparing a reference substance solution, taking a proper amount of ferulic acid reference substances, precisely weighing, and adding a methanoic acid-methyl alcohol (5:95) solution to be prepared into a solution containing 0.600mg per 1mL; taking a proper amount of oxalic acid reference substances, precisely weighing, and adding a methanoic acid-methyl alcohol (5:95) solution to be prepared into a solution containing 0.908mg per 1mL; and detecting the content: respectively precisely absorbing 10 mul of reference substance solution and 10 mul of test solution, pouring into a liquid phase chromatograph, and detecting according to a high-performance liquid chromatography. The method has the advantages of high accuracy, advanced technology and quick and easy operation and can be used for effectively controlling the quality of medicinal material.

Description

technical field [0001] The invention belongs to the field of quality detection of traditional Chinese medicines, and in particular relates to a quality detection method of the traditional Chinese medicinal material. Background technique [0002] The dry aerial part of Polygonum perfoliatum L. belongs to Polygonum perfoliatum L. Harvested when flowering in summer, dried in the sun. The processing method is as follows: remove impurities, wash slightly, cut off and dry. Characters: The stem of this product is slightly square columnar, angular, multi-branched, with a diameter of up to 0.2cm; the surface is purple-red or purple-brown, with anatropous hooks on the corners, slightly enlarged nodes, and the length of the internodes is 2-6cm. Sex, yellow-white, myelinated or hollow. The leaves are alternate, with long stalks and peltate; the leaves are mostly shrunken, and become nearly equilateral triangles after flattening, gray-green to reddish brown, with anatropous barbs on t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70G01N30/02A61P31/04A61P31/12
Inventor 黄家宇刘青
Owner 贵州远程制药有限责任公司
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