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Content measuring method for four components in Chinese medicinal composition

A determination method and composition technology are applied in the directions of pharmaceutical combinations, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., and can solve the problems of time-consuming, increased quality control cost, poor accuracy, and the like, The method is simple and feasible, and the measurement results are accurate and reliable.

Active Publication Date: 2011-05-04
BEIJING YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this poses a challenge to the efficiency of quality control. If fast thin-layer scanning is used for quantification, the accuracy will be poor. If chromatography is used for determination, it will be very time-consuming and significantly increase the cost of quality control. Simultaneous determination of several components in the same chromatographic system is an ideal quality control method

Method used

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  • Content measuring method for four components in Chinese medicinal composition
  • Content measuring method for four components in Chinese medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] In order to facilitate the implementation of the method for determining the content of the Chinese medicine composition, the Chinese medicine composition is prepared as a capsule

[0071] prescription:

[0072] Ginseng 89g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 224g

[0073] Fried Suanzaoren 186g, Sangjisheng 186g, Radix Paeoniae Rubra 89g, Ground Beetle 75g

[0074] Gansong 89g Coptidis 45g Southern Schisandra 67g Keel 149g

[0075] Preparation:

[0076] a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0077] b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong are refluxed and extracted three times with 70% ethanol, the extracts are ...

Embodiment 2

[0092] In order to facilitate the implementation of the method for determining the content of the Chinese medicine composition, the Chinese medicine composition is prepared as a tablet

[0093] prescription:

[0094] Ginseng 45g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 225g Fried jujube seed 186g

[0095] Sangjisheng 186g Radix Paeoniae Rubra 89g Gansong 45g Wood Beetle 35g Coptidis 45g

[0096] Southern schisandra 67g, keel 149g.

[0097] Preparation:

[0098] a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0099] b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong are refluxed and extracted three times with 70% ethanol, the extracts are com...

Embodiment 3

[0116] In order to facilitate the implementation of the method for determining the content of the Chinese medicine composition, the Chinese medicine composition is prepared as granules

[0117] prescription:

[0118] Ginseng 175g Ophiopogon japonicus 192g Cornus officinalis 421g Salvia miltiorrhiza 440g Fried jujube seed 395g

[0119] Sangjisheng 396g Radix Paeoniae Rubra 188g Ground Beetle 98g Gansong 188g Coptidis 85g

[0120] Southern schisandra 147g, keel 278g.

[0121] Preparation:

[0122] a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0123] b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong are refluxed and extracted three times with 70% ethanol, the extracts a...

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Abstract

The invention provides a content measuring method for four components in a Chinese medicinal composition. The Chinese medicinal composition consists of Chinese medicaments such as ginseng, dwarf lilyturf tuber, dogwood, root of red rooted salvia, sauted spina data seed, Chinese taxillus twig, red peony root, ground beetle, nardostachys root and the like. The Chinese medicinal composition is clinically used for treating arrhythmia. The content of paeoniflorin, content of loganin, content of berberine and content of salvianolic acid B in the Chinese medicinal composition are measured at the same time by adopting an efficient liquid phase method; and the method is simple, convenient and feasible, the measurement results are accurate and reliable, and the method can be used for evaluating the quality of the Chinese medicinal composition.

Description

technical field [0001] The invention relates to a content determination method of four components in a traditional Chinese medicine composition. The method adopts high performance liquid chromatography to simultaneously determine the contents of paeoniflorin, loganin, berberine and salvianolic acid B. Background technique [0002] Traditional Chinese medicine is an important weapon in the traditional prevention and treatment of diseases in our country. For thousands of years, it has played an important role in the healthy life of our people. With the development of modern science and technology, traditional Chinese medicine is also facing the problem of modernization. In recent years, the world's understanding of traditional Chinese medicine has gradually deepened, and it has begun to pay attention to it, which shows that the period of rapid development of the international market of traditional Chinese medicine has come. At present, if traditional Chinese medicine wants to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P9/06G01N30/02A61K35/64A61K35/02
Inventor 陈玉平
Owner BEIJING YILING PHARMA
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