Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia

一种口腔组合物、抗氧化剂的技术，应用在抗细菌药、药物组合、羟基化合物有效成分等方向，能够解决口腔护理应用受限等问题

Active Publication Date: 2011-05-04
WM WRIGLEY JR CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite the effectiveness of this antibacterial compound, many of these compounds are regulated by both the U.S. Food and Drug Administration and the European Union, making them comparable in food and confectionery for oral care applications. restricted

Method used

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  • Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia
  • Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia
  • Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Chewing gum formulations (designated "Compositions A, B, and C") included both a magnolol extract containing at least 90% by weight of magnolol and at least 2% by weight of honokiol and an antioxidant The combination of said formulations acts with enhanced activity to kill or inhibit the growth of Streptococcus mutans:

[0071]

Embodiment 2

[0073] A compressed tablet formulation (designated "composition D") comprising a combination of a magnolol extract comprising at least 90% by weight of magnolol and at least 2% by weight of honokiol and an antioxidant, The antioxidants work in a synergistic manner to kill or inhibit the growth of Streptococcus mutans:

[0074] Element

Embodiment 3

[0076] Composition A provides magnolia bark extract in the coating of the chewing gum composition and BHA in the core of the chewing gum composition.

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PUM

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Abstract

An oral composition contains an enhanced antibacterial effective amount of an antioxidant and an extract of Magnolia.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to US Provisional Patent Application Serial No. 61 / 057,501, filed May 30, 2008, which is hereby incorporated by reference. Background of the invention [0003] The present invention relates to antibacterial combinations of antioxidants and extracts of Magnolia officinalis, and more particularly to oral compositions containing such combinations, which exhibit resistance to Streptococcus mutans, a Enhanced oral care effects of bacteria associated with dental caries. [0004] In the prior art, compounds such as chlorhexidine, benzothonium chloride and cetylpyridinium chloride have been used as antibacterial agents in oral compositions. However, oral compositions such as toothpastes and mouthwashes experience reduced utility when anionic surfactants are present which are required for effective performance. In contrast, non-cationic antibacterial substances are compatible wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K31/216A61K36/575A61P31/04
CPCA61K31/05A61K31/216A61K36/575A61P31/04A61P39/06A61K2300/00
Inventor 麦克尔·W·J·多兹詹姆斯·罗伊·麦克斯维尔迈克尔·J·格林伯格田敏敏
Owner WM WRIGLEY JR CO
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