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Gamuzhuer vagina tablet and preparation method thereof

A vaginal tablet and gamu technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., and can solve problems such as high body irritation.

Inactive Publication Date: 2011-05-11
SHENZHEN JIAXUAN MEDICAL TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In his invention, what is prepared is also a suppository, and it is also unavoidable that the suppository base is easy to flow out of the body at body temperature, resulting in a reduction in the dosage of the drug and discomfort in use.
At present, there are also effervescent tablets for vaginal use in China, and effervescent tablets are composed of an acid-base reaction system, which is more irritating to the body.

Method used

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  • Gamuzhuer vagina tablet and preparation method thereof
  • Gamuzhuer vagina tablet and preparation method thereof
  • Gamuzhuer vagina tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] According to the P190 page of the Mongolian medicine sub-volume of the Ministry of Health's drug standard, take Hanshuishi, realgar, and Cassia in proportion, mix and shear and pulverize, pass through a 200 mesh sieve, and get 250g for subsequent use; Pass through a 200-mesh sieve, take 127.5g for later use; weigh cinnabar and silver beads in proportion, mix them, pass through a 200-mesh sieve, take 50g and mix with the two groups of main ingredients taken before, grind finely, and pass through an 80-mesh sieve. The mixture is subjected to jet milling once or twice at a pressure of 0.55Mpa to obtain the desired micronized main drug.

[0045] figure 1 , the particle size of the original drug powder after mixing, X 10 : 2.20 μm; X 50 : 14.24 μm; X 90 : 70.67μm;

[0046] figure 2 , the particle size of the powder after being pulverized once, X 10 : 1.50 μm; X 50 : 10.30 μm; X 90 : 37.42μm;

[0047] image 3 , the particle size of the powder after being pulverize...

Embodiment 2

[0049] Weigh 75g of Gamuzhuer crushed twice in Example 1, 360g of sodium alginate as a bioadhesive agent, 973.5g of lactose as a filler, and 90g of cross-linked polyvinylpyrrolidone as a disintegrant, mix well, press into thin slices, pass 20 Granulate with a mesh sieve, add 1.5 g of magnesium stearate, mix well, and tablet.

Embodiment 3

[0051] Take by weighing Gamu Zhuer 1125g that pulverizes twice among the embodiment 1, chitosan 223.5g, hydroxypropyl cellulose 1.5g that hydroxypropyl molar content is 10%, talcum powder 75g, micropowder silica gel 75g, mix homogeneously, Tablets are available.

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Abstract

The invention discloses a Gamuzhuer vagina tablet and a preparation method thereof. The Gamuzhuer vagina tablet comprises the following components in percentage by weight: 5-75% of Gamuzhuer, 0-30% of biological adhesive, 0-90% of bulking agent, 0.1-10% of disintegrating agent and 0.1-10% of lubricating agent. The invention combines the biological adhesive and the Gamuzhuer, so that the tablet can be disintegrated and attached to the focal part in a shorter time, thereby achieving the purpose of treatment.

Description

technical field [0001] The invention relates to a Gamujuer preparation. Background technique [0002] Cervical erosion is a common and frequently-occurring disease in gynecology. It belongs to the category of "leukorrhagia" in traditional Chinese medicine. The incidence rate accounts for about 60% of gynecological outpatient clinics. It is closely related to the occurrence of cervical cancer. Improving the cure rate of cervical erosion is of great significance to preventing the occurrence of cervical cancer. There are many ways to treat cervical erosion, which can be divided into physical therapy and drug therapy. Physiotherapy needs to be treated with equipment in the hospital, while drug treatment can generally be carried out by patients, which is low in cost and easy to use. [0003] Gamuzhuer, a traditional Mongolian patent medicine, belongs to the classic prescription of Mongolian medicine and has been used in various clinical frontlines in Inner Mongolia for many yea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/20A61P15/00A61K31/045A61K33/06A61K33/28A61K33/36A61K35/55A61K35/618
Inventor 孔徐生金方闻聪王玉杰
Owner SHENZHEN JIAXUAN MEDICAL TECH DEV
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