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Chinese medicinal composition for treating malignant tumor and preparation method thereof

A technology for malignant tumors and compositions, which is applied in the field of pharmaceutical compositions and the preparation of the compositions, traditional Chinese medicine compositions for the treatment of malignant tumors and their preparations, which can solve the problems of decreased quality of life, less consideration of the overall condition of tumor patients, and death from treatment To achieve the effect of clear mechanism, controllable product quality and stable curative effect

Inactive Publication Date: 2012-06-13
ANHUI BIOLOGICAL PEPTIDE IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, despite the continuous advancement of science and technology today, the treatment of tumors is still not ideal
Clinically, the treatment of malignant tumors is still dominated by surgery, radiotherapy and chemotherapy, but surgery or radiotherapy is only suitable for some patients with early stage non-diffusion, which belongs to local treatment; while chemotherapy for tumors is still mainly based on chemically synthesized drugs, such as cyclophosphamide, Carboplatin, cisplatin, Gemzetin, pemetrexed, etc., although most of them have good antitumor effects, have extensive and serious side effects, mainly manifested as bone marrow suppression, gastrointestinal symptoms, mucous membrane, hair damage, heart, liver, lung , nephrotoxicity, and neurotoxicity lead to overall immune function damage, which often leads to the deterioration of the patient's body condition and the decline in the quality of life. Long-term application effect is not good
The reason is that Western medicine only focuses on indicators such as chemotherapy index and tumor inhibition rate in the treatment of tumors, and seldom considers the overall situation of tumor patients, especially the quality of life of patients.

Method used

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  • Chinese medicinal composition for treating malignant tumor and preparation method thereof
  • Chinese medicinal composition for treating malignant tumor and preparation method thereof
  • Chinese medicinal composition for treating malignant tumor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Prescription: Hedyotis diffusa 600g, Astragalus 200g, Poria cocos 200g, Fa Pinellia 120g, Tianlong 120g

[0084] Preparation method: take the above five flavors, take Hedyotis diffusa, Poria and Pinellia, add 10 times the amount of 50% ethanol to reflux and extract once, each time for 1.5h, filter, the filtrate is decompressed to recover ethanol, and set aside; the remaining medicinal residues Add astragalus and 10 times the amount of water to decoct twice, each time for 1.5h, filter, the filtrate is combined with the above spare filtrate, concentrated under reduced pressure, dried, and crushed to obtain extract A; another Tianlong is taken, crushed, and passed through a 24-mesh sieve , add 10 times the amount of water to homogenize for 10 minutes, heat and boil for 30 minutes, let cool to room temperature, use 50% sodium hydroxide solution to adjust the pH to 8, then add 2% trypsin as the substrate, and enzymolyze at 50°C for 4 hours, Stir frequently and adjust the pH ...

Embodiment 2

[0086] Prescription: Hedyotis diffusa 900g, Astragalus 400g, Poria cocos 400g, Fa Pinellia 150g, Tianlong 150g

[0087] Preparation method: take the above five flavors, take Hedyotis diffusa, Poria and Pinellia, add 12 times the amount of 70% ethanol to reflux and extract once, each time for 1.5h, filter, the filtrate is decompressed to recover ethanol, and set aside; the remaining medicinal residues Add astragalus and add 10 times the amount of water to decoct twice, each time for 1.5h, filter, the filtrate is combined with the above spare filtrate, concentrated under reduced pressure, dried, and crushed to obtain extract A; another Tianlong is taken, crushed, and passed through a 50-mesh sieve , add 15 times the amount of water to homogenize for 15 minutes, heat and boil for 10 minutes, let cool to room temperature, use 20% sodium hydroxide solution to adjust the pH to 8, then add 2% trypsin as the substrate, and enzymolyze at 50°C for 3 hours, Stir frequently and adjust the...

Embodiment 3

[0089] Prescription: Hedyotis diffusa 400g, Astragalus 400g, Poria cocos 300g, Pinellia 100g, Tianlong 100g

[0090] Preparation method: take the above five flavors, take Hedyotis diffusa, Poria and Pinellia, add 8 times the amount of 60% ethanol to reflux and extract once, each time for 1.5h, filter, the filtrate is decompressed to recover ethanol, and set aside; the remaining medicinal residues Add astragalus and add 15 times the amount of water to decoct once, each time for 1.5h, filter, combine the filtrate with the above-mentioned spare filtrate, concentrate under reduced pressure to a clear paste with a relative density of 1.10-1.15 (50-60°C), and set aside; Tianlong, pulverized, passed through a 60-mesh sieve, added 20 times the amount of water to homogenate for 30 minutes, heated and boiled for 10 minutes, allowed to cool to room temperature, adjusted to pH 8 with 50% sodium hydroxide solution, and then added 2% trypsin as the substrate. Enzymolysis at 50°C for 4 hours...

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Abstract

The invention discloses a Chinese medicinal composition for treating malignant tumor, belonging to the field of Chinese medicines. The Chinese medicinal composition is a medicament preparation formed from herba oldenlandiae, astragalus root, tuckahoe, prepared pinellia tuber, herba scutellariae barbatae, teloon, scorpion, scolopendra and the like by adopting advanced processes including extraction with water, extraction with ethanol, enzymolysis of trypsinase and the like according to a certain compatible requirement, and the medicament preparation is preferably prepared into capsules and tablets. The Chinese medicinal composition has a certain function for relieving symptoms for lung cancer, liver cancer, gastric cancer, intestinal cancer, breast cancer, encephaloma, lymph cancer and other malignant tumors, reducing tumor bodies, inhibiting the growth of the tumors and the like; and according to the Chinese medicinal composition, the human immune capability can be improved, the livesof patients suffered from tumors can be prolonged and the adverse reactions of leukocytopenia, dizzy, weakness and fatigue, skinniness, poor appetite, nausea and vomiting and the like due to radiotherapy chemotherapy for cancers can be effectively relieved.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method of the composition, in particular to a traditional Chinese medicine composition for treating malignant tumors and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] At present, cancer has become one of the diseases that seriously endanger human health and is difficult to cure. It is the second largest killer of human beings after cardiovascular disease, and has become a serious public health problem. With the change of human living environment and living habits and the acceleration of the pace of life, the incidence of tumors is gradually increasing. According to WTO statistics, the average number of deaths from malignant tumors in the world is 6.9 million per year, and there are about 10 million new cases, which are still increasing year by year; Developing countries in Asia, Africa and Latin America. In my ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8888A61P35/00A61P37/04A61K35/56A61K35/64A61K35/583A61K35/646A61K35/648
Inventor 魏永利代龙
Owner ANHUI BIOLOGICAL PEPTIDE IND RES INST
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