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Metoprolol succinate sustained-release tablets and preparation method thereof

A technology of metoprolol succinate and sustained-release tablets, applied in the field of medicine, can solve the problems of complicated process, high industrialization cost, unsuitable for industrialized production, etc., and achieve the effect of simple process

Inactive Publication Date: 2011-06-08
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above patented process is complicated, the cost of industrialization is high, and it is not suitable for industrial production

Method used

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  • Metoprolol succinate sustained-release tablets and preparation method thereof
  • Metoprolol succinate sustained-release tablets and preparation method thereof
  • Metoprolol succinate sustained-release tablets and preparation method thereof

Examples

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preparation example Construction

[0053] The preferred preparation method of metoprolol succinate sustained-release preparation of the present invention comprises the following steps:

[0054] (i) mixing 100 parts by weight of metoprolol succinate, 200-1000 parts by weight of hypromellose, 5-150 parts by weight of carbomer and a filler, adding a binder to make a soft material;

[0055] (ii) Carrying out granulation, drying and sizing of the soft material, adding a lubricant and pressing it into tablets.

[0056] Any method known in the field of formulations can be used to carry out the steps of mixing, preparing the soft material, granulating, drying, sizing, and tableting the soft material.

[0057] Other sustained-release tablet preparation methods known in the art can also be used to prepare the metoprolol succinate sustained-release preparation of the present invention. For example, dry granulation tableting technology or powder direct compression technology can be used.

[0058] The main advantages of t...

Embodiment 1

[0076] Prescription for Metoprolol Succinate Extended Release Tablets 1

[0077]

[0078] Prescription dosage per tablet (mg)

[0079]

[0080] Metoprolol succinate 47.5

[0081] Lactose 45

[0082] Carbomer 980 (40000-80000 centipoise) 8

[0083] HPMC K15M (15000 centipoise) 170

[0084] HPMC K100CR (100 centipoise) 35

[0085] Magnesium Stearate 3

[0086]

[0087] Preparation:

[0088] Pass metoprolol succinate, hypromellose (viscosity: 15000 centipoise), hypromellose (viscosity: 100 centipoise) and lactose through 80-mesh sieve respectively. Respectively weigh metoprolol succinate, hypromellose (viscosity: 15000 centipoise), hypromellose (viscosity: 100 centipoise), lactose and carbomer 980 and mix well, add 50 The soft material is made of % ethanol aqueous solution, granulated through 20 mesh, dried at 55 d...

Embodiment 2

[0090] Prescription for Metoprolol Succinate Extended Release Tablets 2

[0091]

[0092] Prescription dosage per tablet (mg)

[0093]

[0094] Metoprolol succinate 47.5

[0095] Calcium hydrogen phosphate anhydrous 60

[0096] Carbomer 934P (20000-40000 centipoise) 15

[0097] HPMC K100M (100000 centipoise) 110

[0098] HPMC E50 (50 centipoise) 50

[0099] Magnesium Stearate 3

[0100]

[0101] Preparation:

[0102] Pass metoprolol succinate, hypromellose (viscosity: 100,000 centipoise), hypromellose (viscosity: 50 centipoise), and anhydrous calcium hydrogen phosphate through an 80-mesh sieve respectively. Metoprolol succinate, hypromellose (viscosity: 100,000 centipoise), hypromellose (viscosity: 50 centipoise), anhydrous calcium hydrogen phosphate and carbomer 934P were mixed, and 80% Soft material made from ...

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Abstract

The invention provides metoprolol succinate sustained-release tablets which can be released smoothly and a preparation method thereof, and each metoprolol succinate sustained-release tablet comprises 100 parts by weight of metoprolol succinate, 200-1000 parts by weight of hydroxypropyl methylcellulose and 5-150 parts by weight of carbomer. A hydrophilic gel skeleton is adopted as a sustained-release means, and mixture of the hydroxypropyl methylcellulose and the carbomer is taken as blocking material, thereby being applicable to industrial production. Compared with the commercially available sustained-release tablets, the metoprolol succinate sustained-release tablets have similar in vitro release characteristic.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a metoprolol succinate sustained-release tablet and a preparation method thereof. Background technique [0002] Metoprolol is a selective β1 receptor blocker, which is one of the commonly used drugs for the treatment of hypertension, coronary heart disease, chronic heart failure and arrhythmia. The common metoprolol tablet widely used in China is metoprolol tartrate, which has a short elimination half-life of about 3-4 hours, so the plasma drug concentration fluctuates greatly, and it needs to be taken 2-4 times a day. In order to overcome these shortcomings, several metoprolol tartrate sustained-release preparations have appeared on the market, but because the solubility of metoprolol tartrate is very large (> 700mg / ml), in order to obtain more slow and sustained release metoprolol Purpose, succinate was used instead of tartrate, so that its solubility in water ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/205A61K47/38A61K47/32A61P9/10A61P9/12A61P9/06A61P9/04A61K31/138
Inventor 张建军高缘孙慧娟刘承然姜和平黄金友
Owner CHINA PHARM UNIV
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