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Composition of coral calcium hydroxide and arginine and application thereof

A technology of coral calcium hydride and a composition is applied in the field of the composition of coral calcium hydride and arginine, and can solve the problems of increased oxygen free radical content, ischemia-reperfusion injury and the like

Inactive Publication Date: 2011-06-22
SHANGHAI QUANREN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Some studies have found that after hepatic ischemia-reperfusion, the oxidation system in the body is activated, the anti-oxidation system is inhibited, a large number of oxygen free radicals are generated and the clearance is reduced, and the content of oxygen free radicals in the body increases sharply, thus causing a certain degree of lipid peroxidation reaction, resulting in ischemia-reperfusion injury (HIRI)

Method used

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  • Composition of coral calcium hydroxide and arginine and application thereof

Examples

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example 1

[0017] Example 1: Take hypoxic and hypertensive mice as experimental animal models, divide them into three groups, 10 mice in each group, and feed them with normal feed and feed with arginine, and the ratio of coral calcium hydroxide and arginine is 3:10 feed. The experimental results are as follows (attached table):

[0018]

[0019] Animal experiments have shown that arginine has a certain therapeutic effect on hypoxic arterial hypertension, and the combined application of coral calcium hydroxide and arginine has a better effect than arginine. At the same time, after repeated experiments on mice and changing the ratio of coral calcium hydroxide and arginine in the experiment, the results confirmed that the therapeutic effect is better when the ratio of coral calcium hydroxide to arginine is between 1:10 and 4:10 . Simultaneously, experiments have also confirmed that the composition is safe and nontoxic.

example 2

[0021] A female, 65 years old, with long-term chest tightness, shortness of breath, heart deficiency and fatigue, was diagnosed with coronary heart disease-myocardial ischemia, and was treated with coral calcium hydrogenate and arginine composition. The dosage of the composition was 6 grams per day, and the composition contained coral hydrogenation The therapeutic ratio of the calcium and arginine composition is 1:10, and the composition is taken three times a day for 6 consecutive weeks, and the blood flow of the coronary arteries is obviously improved.

example 3

[0023] A man, a 70-year-old rectal cancer patient with immunosuppression, used a composition of coral calcium hydroxide and arginine for intravenous drip treatment. The dosage of the composition was 30 grams per day, and the composition of coral calcium hydroxide and arginine The treatment ratio was 4:10. One week later, the patient's lymphocyte count, CD4+ cell number, CD4+ / CD8+ ratio and NK cell activity were significantly improved.

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Abstract

The invention discloses a composition of coral calcium hydroxide and arginine and application thereof. The composition mainly comprises the coral calcium hydroxide and the arginine, and the mass ratio of the coral calcium hydroxide to the arginine is 1:10-4:10. The composition can be prepared into granules, tablets, capsules and electuary, is used for preparing health care products for improving human immunity or preparing medicaments or health care products for treating cardio-cerebrovascular diseases. The product has obvious effects of improving human immunity and treating cardio-cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the field of medicine and pharmacy, and in particular relates to a composition of coral calcium hydroxide and arginine and an application thereof. Background technique [0002] Nitric oxide (NO) is a new type of biological information transmitter, which is highly valued by medical scientists at home and abroad. In vivo, in NADPH and O 2 In the presence of nitric oxide, nitric oxide synthase (nitric oxide synthase, NOS) catalyzes the oxidation of L-arginine to produce. NO can activate guanylate cyclase in vascular smooth muscle, increase the concentration of cGMP, mediate and regulate various pathophysiological processes, including platelet adhesion and inhibition, maintenance of basal blood pressure, matching of alveolar blood perfusion and ventilation, Long-term synaptic inhibition, dilation of the corpus cavernosum, microcirculation of the kidney and bone marrow, cytotoxic effects such as killing pathogenic bacteria and att...

Claims

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Application Information

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IPC IPC(8): A61K33/06C01B6/04A61P9/00A61P37/04A61K31/198
Inventor 丛峰松李朝阳
Owner SHANGHAI QUANREN BIOTECH
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