Self-expanding medicament stent and preparation method thereof

A self-expanding, drug-based technology, used in stents, medical science, surgery, etc.

Inactive Publication Date: 2011-07-06
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although drug stents can effectively prevent vascular restenosis, a considerable amount of clinical literature shows that there is a problem of late thrombosis in the treatment of drug stents

Method used

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  • Self-expanding medicament stent and preparation method thereof
  • Self-expanding medicament stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The diameter of the nickel-titanium superelastic stent is 4mm, the length is 60mm, and the diameter of the stent crimping grip is 1mm. The plan view of the bracket is as follows: figure 1 As shown, the stent with mirror-bright surface was obtained by electrochemical polishing method, and the surface of the stent was finely blasted with 15 μm alumina sand material, the sandblasting air pressure was 15 psi, and the sandblasting time was 40 seconds to form a micro-rough surface state. The roughness is 0.1-0.5μm. Then the brackets were washed with acetone and water, respectively, and dried. Mix 5 mg rapamycin and 50 mg PLA, spray on the surface of the stent, and dry to obtain the drug stent.

Embodiment 2

[0034] The nickel-titanium superelastic stent has a diameter of 8mm, a length of 200mm, and a stent crimping diameter of 1.6mm. The plan view of the bracket is as follows: figure 1 As shown, the stent with a mirror-bright surface was obtained by electrochemical polishing. The surface of the stent was finely blasted with 25 μm alumina sand material. The roughness is 1.5-3μm. Then the brackets were washed with acetone and water, respectively, and dried. Mix 5 mg of paclitaxel and 50 mg of PLA, spray on the surface of the stent, and dry to obtain the drug stent.

Embodiment 3

[0036] The diameter of the nickel-titanium superelastic stent is 3.5mm, the length is 40mm, and the diameter of the stent crimping grip is 1mm. Prepare the pickling solution, the proportioning ratio of the pickling solution is HF:HNO3:H2O=1:18:81. Submerge the bracket in the pickling solution for 90 seconds to obtain a micro-rough bracket surface with a surface roughness of 0.5-1 μm, neutralize it with 10% sodium carbonate solution, wash and dry it with pure water. Mix 5 mg rapamycin and 50 mg PLGA, spray on the surface of the stent, and dry to obtain the drug stent.

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Abstract

The embodiment of the invention discloses a self-expanding medicament stent and a preparation method thereof, and the self-expanding medicament stent is characterized by comprising a self-expanding nickel and titanium alloy super-elastic stent body; a medicament coating is coated on the self-expanding nickel and titanium alloy super-elastic stent body; the medicament coating is formed by mixing a medicament capable of inhibiting restenosis with a polymer according to the weight ratio; the polymer has biological degradable property and comprises at least one of PLA (polylactic acid), PGA (polyglycolic acid), PLGA (poly(lactic-co-glycolic acid)) and other artificially synthesized polymer materials or chitosan, algae salt type, bioprotein and other natural polymers. The self-expanding medicament stent disclosed by the embodiment of the invention takes a metal stent as the basis, and the micro-roughening treatment is performed on the surface, thereby increasing the binding force between the surface and the coating and simultaneously promoting the endothelialization of blood vessels.

Description

technical field [0001] The invention relates to the field of interventional medical devices, and more specifically relates to a self-expanding drug stent and a preparation method thereof. Background technique [0002] With the continuous development of endovascular interventional technology, vascular stents have been widely recognized as a means of treating atherosclerotic stenosis. Since the advent of coronary drug stents, it has become the first choice for coronary interventional therapy because it can effectively inhibit vascular restenosis. However, in the field of carotid artery and peripheral blood vessels, especially in the field of lower extremity vascular intervention, nickel-titanium alloy bare stents still occupy the absolute market. After the nickel-titanium alloy bare stent is implanted in stenotic vessels, especially the small-diameter intracranial and subgenital arteries of the lower extremities, the problem of smooth muscle cell proliferation will also occur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/16A61L31/14A61F2/82A61F2/86
Inventor 赵振心周红芳谢志永罗七一郑忠伟赵安昆
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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