Compound picrorhiza rhizome composition for treating hepatic injury and preparation method and application thereof

Abstract

The invention relates to a compound picrorhiza rhizome composition and a preparation method and pharmaceutical application thereof. The composition can be used for treating diseases such as hepatic injury and the like. The preparation method of the traditional Chinese medicine composition comprises the following steps of: extracting picrorhiza rhizome, performing absorption by macroporous absorption resin, washing with water, removing impurities, performing gradient elution with ethanol, recovering the ethanol to obtain an extract of the active components of the picrorhiza rhizome, wherein the content of significant active components of the picrorhiza rhizome, namely picroside I and picroside II, can reach above 50% of the extract in percentage by weight; and extracting volatile oil from bupleurum and white peony root by steam distillation, extracting the dregs, performing absorption by macroporous absorption resin, eluting with distilled water, then performing gradient elution with ethanol, collecting the ethanol eluent, and recovering ethanol to obtain a mixed extract of the active components of the white peony root and bupleurum. The two extracts are combined in a proper proportion, and pharmaceutically acceptable auxiliary materials are added to prepare oral preparations such as capsules, tablets, granules, pills, oral solution and the like, or to prepare injections. The compound picrorhiza rhizome composition has the effects on protecting the liver and treating hepatic injury, and is used for treating and preventing inflammatory injury of various types of hepatitis, fatty liver, alcoholic liver disease and the like. The compound picrorhiza rhizome composition adopts natural vegetable medicines as raw materials, has notable effects on treating hepatic injury, is nontoxic and harmless to human body, and conforms to the national pharmaceutical control laws and regulations.

Description

technical field [0001] The present invention relates to a composition, in particular to a compound Huhuanglian composition for treating liver damage, and the preparation method and application of the composition. The composition is composed of Huhuanglian, Baishao and Bupleurum, and belongs to the new Chinese medicine technology field. The compound preparation has good curative effect on treating liver injury. Background technique [0002] Liver injury is a common pathological change of various liver diseases. At present, various liver diseases such as viral hepatitis, alcoholic liver disease, and drug-induced liver disease are common and frequently-occurring diseases in my country. my country is a high incidence area of ​​hepatitis. About 80% of the total number of hepatitis patients are concentrated in my country. According to statistics, the number of chronic hepatitis B virus carriers in my country has exceeded 130 million, and there are about 30 million chronic hepatit...

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Problems solved by technology

[0007] The compound Huhuanglian composition involved in this patent includes the active ingredient extracts of Huhuanglian, Baishao and Bupleurum three herbs, and the compatibility of the three is used for the treatment of liver damage, and there is no related report

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