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Method of filling liquid sample

A filling method and a technology for covering parts, which are applied in chemical instruments and methods, biochemical equipment and methods, liquid materials, etc., and can solve the problems of affecting sample volume, increasing costs, and prone to deviations in measurement results, etc.

Active Publication Date: 2011-08-17
SEIKO EPSON CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The small amount of test liquid such as sample and reagent will lead to a drop in dispensing accuracy, and the evaporation of the test liquid will seriously affect the amount of sample, and the measurement result is prone to deviation
The dispensing of the liquid to be tested is generally cumbersome and the work time is increased
Extensive consumption of consumables such as pipettes and chips increases inspection costs
Manual dispensing of the test solution is prone to errors, and it is very likely that unoptimized substances will be mixed into the test solution

Method used

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  • Method of filling liquid sample
  • Method of filling liquid sample

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no. 2 Embodiment approach

[0083] Figure 10 , Figure 11 and Figure 13 It is a figure explaining one process of the test method of the test liquid concerning the 2nd Embodiment of this invention ( Figure 10 , Figure 11 and Figure 13 The upper figure is a top view, and the lower figure is a cross-sectional view corresponding to the upper figure). Figure 12 It is for welding with ultrasonic welding device 300 Figure 10 A diagram illustrating the steps of the biochip 200 and the covering member 26 shown, Figure 14 It is to use the ultrasonic welding device 300 to adhere (weld) Figure 11 The figure for explaining the process of the shown biochip 200 and the covering member 26 .

[0084] In the test method of the liquid to be tested according to the present embodiment, using Figure 10 The biochip 200 is shown. The biochip 200 differs from the biochip 100 of the first embodiment in that the end portions 24 a of the plurality of second holes 24 are respectively formed of protrusions 11 . Th...

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Abstract

A method of filling a liquid sample includes: supplying the liquid sample to a first well of a biochip; adhering a cover and the substrate of the biochip in a loop-shaped area surrounding the first well and plural second wells on the substrate; moving the liquid sample from the first well to the second wells through a space between the cover and the substrate by rotating the biochip around a rotation axis in a state in which the biochip is arranged such that a distance from any one of the second wells to the rotation axis in a vertical direction with respect to the rotation axis is longer than a distance from the first well to the rotation axis in the vertical direction with respect to the rotation axis; and sealing the first well and the second wells by adhering the cover to the substrate to thereby seal.

Description

[0001] This application claims priority from Japanese Application No. 2009-282931 filed on December 14, 2009, the entire contents of which are incorporated herein. technical field [0002] The invention relates to a method for filling a liquid to be tested. Background technique [0003] Methods such as chemical analysis, chemical synthesis, and bio-related analysis using a microfluidic chip provided with a microfluidic channel on a glass substrate or the like have attracted attention. The microfluidic chip is called a micro Total Analytical System (micro TAS), a lab-on-a-chip (Lab-on-a-chip), and the like. Compared with conventional analysis devices, microfluidic chips have advantages such as less demand for samples and reagents, shorter reaction time, and less waste. Etc., and the utilization in a wider field is expected (Patent Document 1). Since the above-mentioned microfluidic chip requires a small amount of reagents, the cost of inspection is reduced. Since the requi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCB01L2300/123B01L3/527B01L3/502707B01L2400/0481B01L2200/12B01L3/505B01L3/0293B65B3/04B01L3/50273Y10T436/2575Y10T436/11
Inventor 高城富美男
Owner SEIKO EPSON CORP
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