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Preparation method of ginkgolide B solid dispersion

A technology of solid dispersion and ginkgolide, which is applied in the field of medicine, can solve the problems of low bioavailability, difficult absorption, and low bioavailability, and achieve the effects of increasing bioavailability, low cost, and wide sources

Inactive Publication Date: 2011-10-05
刘全胜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims at the problems that ginkgolide B is difficult to absorb orally and has low bioavailability, and provides a preparation method of ginkgolide B solid dispersion. By adopting solid dispersion technology, it solves the problem of oral administration of ginkgolide B. The problem of low availability improves the bioavailability of oral administration of ginkgolide B to give full play to its therapeutic effect

Method used

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  • Preparation method of ginkgolide B solid dispersion
  • Preparation method of ginkgolide B solid dispersion

Examples

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Effect test

Embodiment 1

[0023] Embodiment 1: preparation ginkgolide B solid dispersion

[0024] Get 150g ginkgolide B, 150g povidone k-30 (PVPk-30) and mix, and add appropriate amount of 75% ethanol to it, make it dissolve completely, make solution I; Stir solution I for 30~60min, carry out The solvent was recovered under reduced pressure, dried in vacuum at 80°C for 6 hours to obtain a solid dispersion, and then the dispersion was crushed and sieved (60 mesh sieve) to obtain the solid dispersion of ginkgolide B.

Embodiment 2

[0025] Embodiment 2: preparation ginkgolide B solid dispersion

[0026] Get 150g ginkgolide B, 300g povidone k-30 (PVPk-30) and mix, and add appropriate amount of 90% ethanol to it, make it dissolve completely, make solution I; Stir solution I for 30~60min, carry out The solvent was recovered under reduced pressure, dried in vacuum at 70° C. for 12 hours to obtain a solid dispersion, and then the dispersion was crushed and sieved (60 mesh sieve) to obtain the solid dispersion of ginkgolide B.

Embodiment 3

[0027] Embodiment 3: preparation ginkgolide B solid dispersion

[0028] Get 150g ginkgolide B, 450g povidone k-30 (PVPk-30) and mix, and add appropriate amount of 95% ethanol to it, make it dissolve completely, make solution I; Stir solution I for 30~60min, carry out The solvent was recovered under reduced pressure, dried in vacuum at 80°C for 18 hours to obtain a solid dispersion, and then the dispersion was pulverized and sieved (60 mesh sieve) to obtain the solid dispersion of ginkgolide B.

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Abstract

The invention relates to the field of medicine and discloses a preparation method of ginkgolide B solid dispersion. The preparation method comprises the following steps of: uniformly mixing ginkgolide B with polyvidone; dissolving in ethanol with the concentration of 70-100 percent; recycling a solvent under reduced pressure; and drying at the temperature 60-80 DEG C for 1-24 hours to obtain the ginkgolide B solid dispersion. The preparation method has the advantages of simple process, low cost, wide solvent source and wide industrial application prospect; and by adopting the ginkgolide B solid dispersion, the bioavailability and stability of the ginkgolide B in an organism can be improved remarkably.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method of ginkgolide B solid dispersion. Background technique [0002] Ginkgo biloba is the dried leaf of Ginkgo biloba L., a plant of the Ginkgo family. Ginkgo biloba contains flavonoids, terpenoids, phenols, alkaloids, polyisoprene, polysaccharides and other active ingredients with pharmacological effects. Ginkgo biloba extract (GBE) has a very strong antioxidant effect, which can eliminate excess free radicals in the body, prevent lipid peroxidation in the body, improve the body's immunity, promote blood circulation and brain metabolism, and also have anti-aging, prevent neurological Systemic diseases and other functions. At present, it is believed that the main active ingredients of GBE are ginkgo flavonoids and ginkgolides, among which ginkgolides are platelet activating factor (PFA) antagonists, so GBE can be mainly used for the treatment of coronary heart disease, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/365A61K47/32A61P7/02A61P9/00
Inventor 展学孔曹俊倪海波周海妹
Owner 刘全胜
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