Preparation method of ginkgolide B solid dispersion

A technology of solid dispersion and ginkgolide, which is applied in the field of medicine, can solve the problems of low bioavailability, difficult absorption, and low bioavailability, and achieve the effects of increasing bioavailability, low cost, and wide sources
CN102204879AInactive Publication Date: 2011-10-05刘全胜
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
刘全胜
Publication Date
2011-10-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of medicine and discloses a preparation method of ginkgolide B solid dispersion. The preparation method comprises the following steps of: uniformly mixing ginkgolide B with polyvidone; dissolving in ethanol with the concentration of 70-100 percent; recycling a solvent under reduced pressure; and drying at the temperature 60-80 DEG C for 1-24 hours to obtain the ginkgolide B solid dispersion. The preparation method has the advantages of simple process, low cost, wide solvent source and wide industrial application prospect; and by adopting the ginkgolide B solid dispersion, the bioavailability and stability of the ginkgolide B in an organism can be improved remarkably.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to a preparation method of ginkgolide B solid dispersion. Background technique

[0002] Ginkgo biloba is the dried leaf of Ginkgo biloba L., a plant of the Ginkgo family. Ginkgo biloba contains flavonoids, terpenoids, phenols, alkaloids, polyisoprene, polysaccharides and other active ingredients with pharmacological effects. Ginkgo biloba extract (GBE) has a very strong antioxidant effect, which can eliminate excess free radicals in the body, prevent lipid peroxidation in the body, improve the body's immunity, promote blood circulation and brain metabolism, and also have anti-aging, prevent neurological Systemic diseases and other functions. At present, it is believed that the main active ingredients of GBE are ginkgo flavonoids and ginkgolides, among which ginkgolides are platelet activating factor (PFA) antagonists, so GBE can be mainly used for the treatment of coronary heart disease, an...

Claims

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