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Antithrombotic medicament for intravenous injection and preparation method and application thereof

An antithrombotic drug and a general formula technology, applied in the field of antithrombotic drugs for intravenous injection and their preparation, can solve the problems of low purity and poor drug activity, and achieve high purity, low degree of polymerization, and inhibition of platelet aggregation and adhesion. effect of action

Active Publication Date: 2011-10-12
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
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  • Claims
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Problems solved by technology

The invention provides an antithrombotic drug for intravenous injection and its preparation method and application, which can solve the problems of low purity and poor drug activity in the prior art

Method used

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Abstract

The invention provides an antithrombotic medicament for intravenous injection. The medicament is a modified acidic polysaccharide consisting of only one monosaccharide and has a structural general formula, wherein R is -CH3 or -CH2-CH(OH)-CH3; R' is -H or -SO3Na; each sugar ring has at least one R' which is -SO3Na; n is equal to 2 to 6; when R is -CH3, the compound represented by the structural general formula is an oligomannuronicacid methyl acetate sulfate sodium salt; and when R is -CH2-CH(OH)-CH3, the compound represented by the structural general formula is an oligomannuronicacid proply acetate sulfate sodium salt. The medicament for intravenous injection has obvious anticoagulation, wherein the anticoagulation titer is 17 to 23; rabbit collagen induced platelet aggregation and platelet adhesion are obviously inhibited; and local ischemic brain damage caused by formation of cerebral thrombosis is lessened by inhibiting the formation of cerebral thrombosis and ischemic brain tissues are obviously protected.

Description

technical field The invention belongs to the field of pharmaceutical preparations, and in particular relates to an antithrombotic drug for intravenous injection and its preparation method and application. Background technique The present invention relates to a novel mannuronic acid derivative. Patent No. ZL88109698.9 is an invention patent, which discloses a method for preparing mannuronic acid propyl ester sulfate. This approach demonstrates a general method for the preparation of such compounds. The compound produced by this method belongs to a series of heparin-like substances. During the preparation process, due to the different technical conditions in the important process links, such as the preparation, grading, esterification and sulfonation of mannuronic acid, a series of derivatives with different structures will be produced. Compounds with different structures also exhibit different biological activities. Therefore, the preparation method of the ZL88109698.9 pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10C12P19/04A61K31/727A61P7/02
Inventor 管华诗于广利李桂玲江晓璐李春霞
Owner OCEAN UNIV OF CHINA
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