Medicament for preventing and treating diabetes and complications thereof and preparation method thereof

A technology for complication and type 2 diabetes, which is applied in the field of non-synthetic drugs, can solve problems such as the influence of glucose and lipid metabolism, rough extraction methods, and non-classical preparation of diabetes models, and achieve clear functions, no toxic side effects, and long-lasting effects

Active Publication Date: 2011-10-26
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the oral hypoglycemic drugs approved for use in my country include insulin secretagogues (sulfonylureas, glinides) and non-insulin secretagogues (α-glucosidase inhibitors, biguanides, thiazolidinedione insulin sensitizers) ), but they cannot fundamentally solve the two most significant problems of maintaining long-term efficacy in reducing hyperglycemia and effectively relieving the disease according to the cause. Therefore, finding new therapeutic drugs has always been a research hotspot in this field
Although it has been reported that the single herb Mirabilis root can reduce the blood sugar

Method used

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  • Medicament for preventing and treating diabetes and complications thereof and preparation method thereof
  • Medicament for preventing and treating diabetes and complications thereof and preparation method thereof
  • Medicament for preventing and treating diabetes and complications thereof and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Obtaining the Alcoholic Extract of Radix Mirabilis

[0086] After the Mirabilis root was crushed into a coarse powder, it was leached with 5 times the amount of 50% ethanol at room temperature for 3 times, each time for 24 hours, and the filtrate was combined and filtered; concentrated under reduced pressure using a rotary evaporator; vacuum-dried to obtain the alcoholic extract of Mirabilis root, The extraction rate is 12.5%.

Embodiment 2

[0088] Obtaining the Alcoholic Extract of Radix Mirabilis

[0089] After the root of Mirabilis is crushed into coarse powder, it is extracted with 10 times the amount of 95% ethanol at room temperature for 3 times, each time for 48 hours, and the filtrate is combined and filtered; concentrated under reduced pressure using a rotary evaporator; dried in vacuum to obtain the alcoholic extract of Mirabilis root , the extraction rate was 13.0%.

Embodiment 3

[0091] Obtaining the Alcoholic Extract of Radix Mirabilis

[0092] After the Mirabilis root was crushed into a coarse powder, 12 times the amount was extracted with 70% ethanol under reflux for 3 times, each time for 2 hours, and the filtrate was combined and filtered; concentrated under reduced pressure using a rotary evaporator; vacuum-dried to obtain the alcoholic extract of Mirabilis root, The extraction rate was 14.1%.

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PUM

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Abstract

The invention relates to a single-herb Chinese medicine of common four-o'clock roots for preventing and treating diabetes and complications thereof, and a preparation method thereof. The single-herb Chinese medicine contains the active components which are extracted from common four-o'clock roots by means of ethanol reflux extraction, reduced pressure concentration and vacuum drying treatment. The pharmacological studies show that the single-herb Chinese medicine has the effects of reducing blood sugar and lipid levels, reducing triglyceride levels in the liver and the skeletal muscles and increasing glycogen levels in the liver and the skeletal muscles, produces hypoglycemic and hypolipidemic effects in both preventative and therapeutic applications, causes no adverse effect on glucose and lipid metabolisms in healthy mice, and can be used for preventing and treating type II diabetes and complications caused thereby. The invention provides a pure natural medicament for the patients suffering from type II diabetes and complications thereof.

Description

technical field [0001] The invention relates to a non-synthetic medicine for preventing and treating type 2 diabetes and its complications, which is prepared from Chinese herbal medicines. Background technique [0002] Diabetes has become the third major disease that seriously endangers human health after tumors and cardiovascular and cerebrovascular diseases. Data from the World Health Organization and the International Diabetes Federation indicate that the total number of diabetic patients in the world will reach 333 million by 2025. According to the results of diabetes census published in 19 provinces and cities in my country, with the increase of average life expectancy, the increase of economic income and the change of lifestyle (such as eating more and moving less, mental stress, smoking and drinking, etc.), the total number of diabetic patients will increase by at least 100 per year. million increased. In the past 20 years, the incidence of diabetes in my country has...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/10A61K125/00
Inventor 周吉银周世文
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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