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Application of loganin in preparation of drugs or health products for preventing and treating mental disorder diseases, such as depression and anxiety disorder

A technology for mental disorders and loganin, which is applied in the field of medicine, can solve the problems of poor extract effect, complex chemical composition, unfavorable processing of medicines or health products, etc., and achieves good application development prospects, wide sources, and effective antidepressant effect. Effect

Active Publication Date: 2017-09-29
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This result shows that the chemical composition contained in the whole powder suspension of Cornus officinalis and each extract of Cornus officinalis is complex, and the main component is not loganin, so it can be seen that the suspension of Cornus officinalis described in Chinese patent (CN103505491 A) and the extract play a role There are multiple chemical components that have pharmacological effects, and multiple chemical components also interact with each other; the extracts in the prior art are not effective, and it is not conducive to be directly processed into corresponding medicines or health products as raw materials

Method used

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  • Application of loganin in preparation of drugs or health products for preventing and treating mental disorder diseases, such as depression and anxiety disorder
  • Application of loganin in preparation of drugs or health products for preventing and treating mental disorder diseases, such as depression and anxiety disorder
  • Application of loganin in preparation of drugs or health products for preventing and treating mental disorder diseases, such as depression and anxiety disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Effect of loganin on autonomic activity of normal mice

[0033]In this experiment, 20-24g male ICR mice were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (animal certificate number: SCXK (Beijing) 2012-0001). The breeding temperature was 23±2°C, and the lighting time was 12 mice per day (turn on the lights from 7:00 to 19:00). Experiments were carried out after one week of feeding. The mice were randomly divided into 4 groups according to body weight, 10 in each group, respectively blank control group (distilled water), low-dose loganin group (5mg / kg), medium-dose loganin group (20mg / kg) and loganin Qiangside high-dose group (50mg / kg). The tested drugs were all dissolved in distilled water at 10ml / kg body weight before the experiment, and administered by intragastric administration. Immediately after administration, the mice were put into the mouse autonomic activity recorder, and the locomotor counts of the mice were record...

Embodiment 2

[0035] Example 2 Effect of loganin on behavior of mice forced swimming test

[0036] For the stress load test, male ICR mice with a body weight of 20-24 g were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (animal certificate number: SCXK (Beijing) 2012-0001). The breeding temperature is 23±2°C, and the lighting time is 12 hours / day (turn on the lights from 7:00 to 19:00). Experiments were carried out after one week of feeding. This experiment is divided into three days, and the first and second days are training days. Be about to add water in the swimming box to the center of the pulley, about 18cm in height, this water level can ensure that the mouse will not climb out of the box by the pulley when swimming, and will not be too tired because the pulley cannot be reached. The water temperature is kept at 22-23°C. During the training, put the mouse into the water facing the pulley gently, make it swim for 10 minutes, take it out, dry it and p...

Embodiment 3

[0041] Example 3 Effect of loganin on the behavior of mice tail suspension experiment

[0042] The mice were randomly divided into 4 groups, and the grouping was the same as above. After 1 hour of intragastric administration, the tail of the mice was glued to the line with adhesive tape at a distance of 2 cm from the end, and connected to the muscle tension transducer to make it hang upside down. The instrument is connected to a desktop balance recorder and placed in a box with its head about 5 cm from the bottom of the box. The hanging time is 6cm, and the immobility time within 4min after accumulation.

[0043] The experimental results are shown in Table 2. In the tail suspension experiment, when 20mg / kg and 50mg / kg loganin were given by intragastric administration, the immobility time of mice could be significantly reduced, and the immobility time of mice could be significantly reduced under the two doses. Compared with the blank control group, there were significant stati...

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Abstract

The invention belongs to the field of compound drugs, relates to a new application of a loganin drug and particularly relates to an application of loganin in preparation of drugs or health products for preventing and treating mental disorder diseases, such as depression and anxiety disorder. The research shows that the loganin is capable of reducing autonomous motion strength of a mouse, obviously increasing the number of turns of rotation of a pulley stirred by fore limbs of the mouse, shortening the tail suspension immobility time of the mouse and displaying an anti-depression effect; the loganin is capable of increasing the stay time percentage of the mouse on an open arm of a maze and the open arm exploration frequency; and meanwhile, in a light-dark box shuttle experiment, the loganin is capable of significantly increasing the standing time of the mouse in a light box and the shuttling frequency in the light box and displaying an obvious anti-depression effect. In conclusion, the loganin can be prepared into the drugs or health products for preventing and treating the mental disorder diseases, such as the depression and the anxiety disorder.

Description

technical field [0001] The invention belongs to the field of medicaments, and relates to a new drug application of loganin, in particular to the application of loganin in the preparation of drugs or health care products for preventing and treating depression, anxiety and other mental disorders. technical background [0002] Mental disorders, also known as mental illnesses, refer to abnormalities in perception, thinking, emotion, behavior, volition, intelligence, and other psychomotor aspects caused by brain dysfunction under the influence of biological, social, and psychological factors. With the development of society, people pay more and more attention to mental disorders. [0003] Anxiety, depression, etc. are common types of mental disorders, and their incidence rate is very high. At present, they have become the second most important diseases that cause serious burdens on human beings, causing pain to patients and their families, and losses to society. It is unmatched ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/24A61P25/22
CPCA61K9/08A61K9/1652A61K9/2054A61K9/4866A61K31/7048
Inventor 张维库续洁琨赫军乔灏祎叶贤胜
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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