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Yanning capsule and its preparation method

A technology for enteritis and tonsillitis, applied in the field of Yanning capsule and its preparation, can solve the problems of incomplete extraction of active ingredients, low bioavailability and the like

Active Publication Date: 2011-11-30
哈药集团三精千鹤制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is used to treat upper respiratory tract infection, tonsillitis, urinary tract infection, acute bacillary dysentery, enteritis and other diseases, but there are deficiencies such as incomplete extraction of active ingredients and low bioavailability

Method used

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  • Yanning capsule and its preparation method
  • Yanning capsule and its preparation method
  • Yanning capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 976.56g of velvet antler, 488.28g of Hedyotis diffusa, and 488.28g of Commelina officinalis, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 20Mpa, the extraction temperature is 30°C, the separator pressure is 5Mpa, the separator temperature is 40°C, and the separation time is 2 hour, the flow rate of carbon dioxide is 20L / H, the supernatant is obtained, the filtrate is concentrated and dried, and the extract is pulverized into an ultrafine powder with a particle diameter of <50 microns (completely passing through a 300 mesh sieve) by means of a jet mill, adding pharmaceutically acceptable The excipients are mixed and encapsulated to make 1000 capsules.

specific Embodiment 2

[0015] Take 2929.68g of velvet grass, 1464.84g of Hedyotis diffusa, and 1464.84g of Commelina officinalis, and extract them by carbon dioxide supercritical extraction method, the extraction pressure is 50Mpa, the extraction temperature is 60°C, the separator pressure is 10Mpa, the separator temperature is 60°C, and the separation time is 6 hour, the flow rate of carbon dioxide is 30L / H, the supernatant is obtained, the filtrate is concentrated and dried, and the extract is pulverized into an ultrafine powder with a particle diameter of <50 microns (completely passing through a 300 mesh sieve) by using a jet mill, and adding pharmaceutically acceptable The accepted excipients were mixed and encapsulated to make 1000 capsules.

Embodiment 3

[0017] Take 1953.12g of velvet antler, 976.56g of Hedyotis diffusa, and 976.56g of Commelina officinalis, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 35Mpa, the extraction temperature is 45°C, the separator pressure is 8Mpa, the separator temperature is 50°C, and the separation time is 4 hour, the flow rate of carbon dioxide is 25L / H. The supernatant is obtained, the filtrate is concentrated and dried, and the extract is pulverized into a superfine powder with a particle size of <50 microns (completely passing through a 300 mesh sieve) with an airflow mill, and the pharmaceutically acceptable excipients are added to mix well and pack into capsules Make 1000 capsules.

[0018] (1) the inspection method of Yanning capsule embodiment:

[0019] [Identification] (1) Take 1g of this product, add 20ml of ethanol to soak for several minutes, filter, take 2ml of the filtrate, add 1-2 drops of ferric chloride test solution, and it will ...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine for treating the respiratory tract infection, the amygdalitis, the urinary tract infection, the acute bacillary dysentery and the enteritis. The preparation method comprises the following steps of: preparing 1953.12g of herb of savatier monochasma, 976.56g of oldenlandia diffusa and 976.56g of common dayflower herb, adopting a carbon dioxide supercritical extraction method to obtain supernatant liquor, concentrating the filtrate, drying, crushing extractum into fine powder by using an airflow crushing machine, adding an excipient, mixing uniformly and then bagging. The preparation method has the advantages that the extraction of active ingredients is complete, the bioavailability is high, the absorption is good, the quality is stable and the repeatability is good and the like.

Description

A technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Yanning capsule for treating upper respiratory tract infection, tonsillitis, urinary tract infection, acute bacillary dysentery and enteritis and a preparation method thereof. Two background technology [0002] Yanning Capsules, clear away heat and detoxify, reduce inflammation and stop dysentery. It is used for the treatment of upper respiratory tract infection, tonsillitis, urinary tract infection, acute bacillary dysentery, enteritis and other diseases, but there are deficiencies such as incomplete extraction of active ingredients and low bioavailability. Three invention content [0003] In order to overcome the above disadvantages, the purpose of the present invention is to provide a Yanning capsule with complete extraction of active ingredients, high bioavailability and stable quality and its preparation method by modern high-tech means. [0004] Yanning C...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61P1/00A61P1/04A61P11/00A61P11/04A61P13/00
CPCY02A50/30
Inventor 武凤梅孙开敬郑玉梅费建军朱文军李尚晏尹逊录
Owner 哈药集团三精千鹤制药有限公司
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