Composition containing sesamins and epigallocatechin gallate

A technology of epigallocatechin and gallate, which is applied in the field of in vivo absorbable compositions, can solve the problems of many ingested particles, complex procedures, and large preparations, and achieve high safety, strong antioxidant activity, and improved Absorbent effect

Active Publication Date: 2014-01-08
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when it is made into a preparation, the preparation becomes too large, especially when it is made into a capsule etc., there is a problem that the number of ingested grains becomes too much
On the other hand, when forming micelles for the purpose of improving absorbability, it is necessary to uniformly emulsify fat-soluble substances, and there is also a problem that a complicated process is required

Method used

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  • Composition containing sesamins and epigallocatechin gallate
  • Composition containing sesamins and epigallocatechin gallate
  • Composition containing sesamins and epigallocatechin gallate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1 Effects of Epigallocatechin Gallate (EGCG) on the In vivo Absorption of Sesamins

[0060] To investigate the influence of EGCG on the in vivo absorbability of sesamin, and in order to investigate the relevance of the antioxidant effect of EGCG, ascorbic acid (vitamin C or VC), which is a representative antioxidant, was used to investigate the effect on sesamin. The effect of absorbability in the body is compared with the results when using EGCG and the control.

[0061] SD (IGS) male rats (8 weeks old) were purchased from Charles River Corporation, Japan, and domesticated in the test environment for 1 week, and the animals showing smooth development were selected for the test. The rats after one night of fasting were divided into 3 groups, 4 in each group, and a 1: 1 mixture of distilled water 5ml / kg and sesamin and episesamin (purchased from Takemoto Oil Co., Ltd.: hereinafter also referred to as " The olive oil solution (10mg / 3ml) 3ml / kg of sesamin class...

Embodiment 2

[0078] Embodiment 2: prescription example

preparation example 1

[0079] (Preparation Example 1) Granules

[0080]

[0081] After uniformly mixing the above powders, add 100 ml of 10% hydroxypropylcellulose-ethanol solution, knead, extrude, and dry according to the usual method to obtain granules.

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PUM

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Abstract

The present invention aims to provide a means for promoting the absorption of sesamins in the body. By using sesamins in combination with epigallocatechin gallate, the absorption of sesamins in the body can be promoted.

Description

technical field [0001] The present invention relates to a composition for promoting the in vivo absorption of sesamin, an in vivo absorption enhancer of sesamin, and food, drink or pharmaceuticals using the same. Background technique [0002] Sesamin is a type of lignan compounds contained in sesame. Among them, sesamin and episesamin as its stereoisomer have been reported: blood cholesterol lowering effect and blood neutral lipid lowering effect, liver function improvement effect, active oxygen scavenging effect, Δ5 desaturase inhibition Various physiological activities such as antihypertensive effect, lipid peroxidation production inhibitory effect, antihypertensive effect, drunkenness prevention effect, and breast cancer inhibitory effect (Patent Document 1). [0003] However, lignan compounds including sesamin are almost insoluble in water, and are soluble only to some extent in organic solvents that can be used for medicine or food. Due to such poor solubility, there ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/36A61K31/353A61P1/16A61P3/06A61P9/12A61P35/00A61P39/02A61P39/06A61P43/00
CPCA61K31/353A61K31/36A61K9/0014A61P1/08A61P1/16A61P3/06A61P9/12A61P35/00A61P39/02A61P39/06A61P43/00A61K2300/00
Inventor 富森菜美乃小野佳子
Owner SUNTORY HLDG LTD
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